Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

38results about How to "Solve the greater risk" patented technology

Endoscopic and Transesophageal Oropharyngeal Airway

An oropharyngeal airway for use during diagnostic and surgical procedures, comprising a body with a proximal and a distal end. The distal end is sized for insertion through a protective bite block disposed in a patient's mouth. Both sides of the distal end are tapered to a curved distal edge. A flange is transversely opposed at the proximal end, preventing the proximal end from moving through the protective bite block and into the patient's mouth. An elliptically-arched channel in the shape of a lingual contour extends from the proximal end to the distal end. The channel includes a pair of tapered upstanding walls that guide the passage of a surgical instrument through the space between them. The oropharyngeal airway can be constructed of recyclable or biodegradable materials and is compatible with protective bite blocks of all sizes.
Owner:THE LETHEAN CO LLC

Bicycle fork and steering tube

InactiveUS7591474B1Reduce weightSuperior and weight-reducing constructionPassenger cyclesWheel based transmissionWrenchAbutment
A combination bicycle fork and steering tube assembly is formed with a pair of downwardly directed, mutually converging end closure tabs that are bent over into abutment and welded together to define peripherally enclosed fork openings at the ends of the steerer tube. The upper ends of the hollow fork legs are configured to follow the surface contours of the lower end of the steerer tube and are welded to the end closure tabs about the circumferences of the enclosed fork openings at the lower end of the steering tube. The front wheel axle dropouts are formed directly in the lower ends of the fork legs, which include internal dropout support inserts. The dropout support inserts are sandwiched in between a pair of flat, mutually parallel dropout tabs defined directly in the lower ends of the fork legs. The preload bolt has an internal partition that defines a wrench socket that is radially displaced from the axial center of the preload bolt. A large cable routing passage is thereby created through the hollow preload bolt.
Owner:BEARCORP

Method for Detecting a Genetic Variant

The present invention provides a method for detecting a genetic variant in a region of interest in a DNA sample comprising (i) determining, for a given sequencing platform, sequencing process and sequencing depth, the distribution of the number of reads supporting a genetic variant or plurality of genetic variants expected to be observed in the sequencing results of amplification reactions due to amplification and sequencing error (read count distribution); (ii) based on the read count distribution determined in step (i), establishing a threshold frequency at or above which the genetic variant must be observed in sequencing results of amplification reactions to assign a positive determination for the presence of the genetic variant in a given amplification reaction; (iii) partitioning the DNA sample into a plurality of replicate amplification reactions, so that the mean number of amplifiable template molecules of the region of interest in a replicate amplification reaction is fewer than the reciprocal of the threshold frequency determined in step (ii); (iv) performing the amplification reactions of step (iii) and sequencing the products of amplification reactions, (v) based on step (ii) and the results of step (iv), determining the presence/absence of the genetic variant in each replicate amplification reaction; and (vi) integrating the results of (v) to determine the presence/absence of the genetic variant in the region of interest in the DNA sample.
Owner:CANCER RES TECH LTD

Battery operated electrical tool

InactiveUS20030115995A1Shorter and designLess tail-heavyDrilling rodsConstructionsElectric drivePower tool
A battery-operated electrical tool (10) is provided with a machine housing (11) that has a longish, substantially rod-shaped housing portion (12) containing an electric drive motor (13) and an end portion (15) on which a terminal connection surface (16) with push-in receptacle (17) for the detachable attachment of a battery packet (14) is provided, which said battery packet is provided with a connection part (18) that comprises a seating surface (19) matched to the connection surface (16) for seating on said connection surface, and comprising a push-in part (20) engaging in the push-in receptacle (17). The end portion (15) is inflected toward one side in relation to the housing portion (12) out of the direction of longitudinal extension. The terminal connection surface (16) of the end portion (15) extends within a plane (21) that is oriented skew in relation to a plane (22) extending substantially perpendicularly to the longitudinal axis (23) of the housing portion (12).
Owner:ROBERT BOSCH GMBH

Method for detecting a genetic variant

The present invention provides a method for detecting a genetic variant in a region of interest in a DNA sample comprising (i) determining, for a given sequencing platform, sequencing process and sequencing depth, the distribution of the number of reads supporting a genetic variant or plurality of genetic variants expected to be observed in the sequencing results of amplification reactions due to amplification and sequencing error (read count distribution); (ii) based on the read count distribution determined in step (i), establishing a threshold frequency at or above which the genetic variant must be observed in sequencing results of amplification reactions to assign a positive determination for the presence of the genetic variant in a given amplification reaction; (iii) partitioning the DNA sample into a plurality of replicate amplification reactions, so that the mean number of amplifiable template molecules of the region of interest in a replicate amplification reaction is fewer than the reciprocal of the threshold frequency determined in step (ii); (iv) performing the amplification reactions of step (iii) and sequencing the products of amplification reactions, (v) based on step (ii) and the results of step (iv), determining the presence / absence of the genetic variant in each replicate amplification reaction; and (vi) integrating the results of (v) to determine the presence / absence of the genetic variant in the region of interest in the DNA sample.
Owner:CANCER RES TECH LTD

Method of making a non-volatile double gate memory cell

A method of making a non-volatile double-gate memory cell. The gate of the control transistor is formed with a relief of a semiconductor material on a substrate. The control gate of the memory transistor is formed with a sidewall of the relief of a semiconductor material configured to store electrical charge. A first layer is deposited so as to cover the stack of layers. The first layer is etched so as to form a first pattern juxtaposed on the relief. A second layer is formed on the first pattern. The second layer is etched so as to form on the first pattern a second pattern having a substantially plane upper face.
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Dosing regimen of activated protein c and variants having reduced anticoagulant activity

Recombinant activated protein C (APC) and APC variants with reduced anticoagulant activity were used to reduce mortality in murine models of sepsis. These models included endotoxemia and bacteremia models. We discovered that single or multiple bolus doses of APC, especially of APC variants such as RR230/231AA-APC, KKK192-194AAA-APC and 5A-APC (containing the combination of mutations present in the first two APC variants) given as a single bolus reduces 7-day mortality of mice given lethal doses of endotoxin. Administrations of a single bolus of 5A-APC after the initiation of sepsis also reduces mortality caused by LPS. 5A-APC with ≦8% of normal anticoagulant activity (which has reduced risk of bleeding) reduces mortality when given as two bolus administrations at 3 hours and then at 10 hours after initiation of bacterial infection, i.e. after onset of sepsis. This shows, first, that one or more bolus injections of APC or of APC variants, especially 5A-APC, can reduce mortality when given beginning hours after the onset of sepsis and, second, that it is not necessary to administer APC as a continuous infusion which is the current standard of practice because one or more bolus administrations can reduce mortality. Furthermore, dosages of approximately 0.06 to 0.4 mg/kg of APC and APC variants are identified to be sufficient to reduce mortality in sepsis.
Owner:VERSITI BLOOD RES INST FOUND INC +1
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products