The invention is based on the discovery that INSP100 is a splice variant of human chorionic somatomammotropin hormone 2 (HCS-B; Q14407) and that INSP104 is a splice variant of human chorionic somatomammotropin hormone 1 (hCS-A;P01243). The invention relates to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease. This invention relates to novel proteins, termed INSP100 and INSP104, herein identified as novel splice variants of human Chorionic somatomammotropin hormone 2 (hCS-B; Q14407) and human Chorionic somatomammotropin hormone 1 (hCS-A; P01243) respectively and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease. The variants have an altered A-B loop and are therefore predicted to possess altered receptorbinding properties. All publications, patents and patent applications cited herein are incorporated in full by reference.
The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lungcancer patients.
A shroud lock for locking a position of a needle shroud relative to a housing of an autoinjector, includes a shroud beam arranged on the needle shroud and biased radially outwards, a stop arranged within the housing, a recess arranged proximal of the stop, and a cap coupled to the housing and adapted to prevent distal translation of the needle shroud relative to the housing. At least a portion of the shroud beam is within the recess when the cap is in place and, the shroud beam abuts the stop after the needle shroud is locked relative to the housing of the autoinjector. The disclosure further relates to an autoinjector and to a method for assembling such an autoinjector.