The invention discloses a condensed-planting and high-yield cultivation method for hybrid seed production of Xinjiang honey melons. According to the condensed-planting and high-yield cultivation method, an under-film double-row drip irrigation mode is adopted, the density of female plants is increased to 5500 plants / mu, and primary pruning is performed to remove all side vines (buds) and keep one main vine when the main vine grows to 10cm; each plant is subjected to pollination by one female flower, all side buds on the entire main vine are removed during pollination, pinching is performed, a water-soluble N (nitrogen), P (phosphorus) and K (potassium) water-flush fertilizer is applied with water drops immediately after pollination, and thereafter, the fertilizer is applied in water drips once for every 5-7 days, wherein the N, the P and the K are formulated according to the mass ratio of 24: 6: 10. The condensed-planting and high-yield cultivation method has the advantages that by means of performing water-drip fertilizer application once for every 5-7 days after primary fertilizer application, nutrition supply of pollinated honey melons is guaranteed, premature senility of the vines is prevented, the fruit setting rate is guaranteed, and growing of each honey melon is guaranteed; the number of cultured honey melons is increased, land is utilized reasonably, water resource is saved, fertilization is facilitated, the degree of field moisture is decreased, pest and disease damage is reduced, and the purpose of increasing the yield of honey melon seeds is achieved.