Disclosed are a handover method, a master evolved NodeB (MeNB) and a secondary evolved NodeB (SeNB), wherein, the method is applied to perform a handover on a MeNB for a user equipment (UE) in a multi-connection scenario in which the UE has connections with both a master evolved NodeB (MeNB) and a secondary evolved NodeB (SeNB), including: a source MeNB initiating a handover, and sending a handover command to the UE after receiving a corresponding response, instructing the UE to perform the handover on the MeNB via the handover command, and remaining a connection with the SeNB; after the UE successfully accesses a destination MeNB, the source MeNB or the destination MeNB sending a handover instruction message to the SeNB connected with the UE, the SeNB connected with the UE establishing an association with the destination MeNB according to the handover instruction message.