204 results about "Ultrasound angiography" patented technology

The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound (“IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature.

Imaging apparatus, is provided, comprising a first device, for obtaining a first image, by a first modality, selected from the group consisting of SPECT, PET, CT, an extracorporeal gamma scan, an extracorporeal beta scan, x-rays, an intracorporeal gamma scan, an intracorporeal beta scan, an intravascular gamma scan, an intravascular beta scan, and a combination thereof, and a second device, for obtaining a second, structural image, by a second modality, selected from the group consisting of a three-dimensional ultrasound, an MRI operative by an internal magnetic field, an extracorporeal ultrasound, an extracorporeal MRI operative by an external magnetic field, an intracorporeal ultrasound, an intracorporeal MRI operative by an external magnetic field, an intravascular ultrasound, and a combination thereof, and wherein the apparatus further includes a computerized system, configured to construct an attenuation map, for the first image, based on the second, structural image. Additionally, the computerized system is configured to display an attenuation-corrected first image as well as a superposition of the attenuation-corrected first image and the second, structural image. Furthermore, the apparatus is operative to guide an in-vivo instrument based on the superposition.

The invention relates to a medical system for introducing a catheter into a vessel, preferably a blood vessel of a patient, having at least a computer and control unit, a means for creating a transparent general view of the position of the vessel, a catheter with a reversible inflatable balloon located in the front area, to the outside of which a stent can be fitted for implanting into the vessel, a position locating system for the catheter with position and location sensors that can determine the position and location of the front area of the catheter in the space, the system being fitted in the front area with at least one OCT (optical coherence tomography) sensor at a catheter end for the close-up area, with at least one IVUS (intravascular ultrasound) imaging sensor at a catheter end for the remote area and the computer and control unit having image processing and image display functions for the image sensors.

A set of intravascular ultrasound (IVUS) related systems, apparatuses and methods are disclosed. New catheter designs including contrast agent introduction subsystems and / or Doppler subsystems are disclosed. Methods for acquiring and analyzing Doppler data from intravascular ultrasound (IVUS) catheters are disclosed. RF-based detection of blood and / or contrast agents such as micro-bubbles are disclosed. Methods for frame-grating image data analysis permitting frame registration before, during and after a contrasting effect is imposed on a system being imaged are disclosed. Methods for difference imaging for contrast detection are disclosed. Methods for quantification and visualization of IVUS data are disclosed. And methods for IVUS imaging are disclosed.

A method and system for co-registration of angiography data and intra vascular ultrasound (IVUS) data is disclosed. A vessel branch is detected in an angiogram image. A sequence of IVUS images is received from an IVUS transducer while the IVUS transducer is being pulled back through the vessel branch. A fluoroscopic image sequence is received while the IVUS transducer is being pulled back through the vessel branch. The IVUS transducer and a guiding catheter tip are detected in each frame of the fluoroscopic image sequence. The IVUS transducer detected in each frame of the fluoroscopic image sequence is mapped to a respective location in the detected vessel branch of the angiogram image. Each of the IVUS images is registered to a respective location in the detected vessel branch of the angiogram image based on the mapped location of the IVUS transducer detected in a corresponding frame of the fluoroscopic image sequence.

An intravascular ultrasound probe is disclosed, incorporating features for utilizing an advanced transducer technology on a rotating transducer shaft. In particular, the probe accommodates the transmission of the multitude of signals across the boundary between the rotary and stationary components of the probe required to support an advanced transducer technology. These advanced transducer technologies offer the potential for increased bandwidth, improved beam profiles, better signal to noise ratio, reduced manufacturing costs, advanced tissue characterization algorithms, and other desirable features. Furthermore, the inclusion of electronic components on the spinning side of the probe can be highly advantageous in terms of preserving maximum signal to noise ratio and signal fidelity, along with other performance benefits.

The present invention generally relates to intravascular ultrasound (IVUS) image segmentation methods, and is more specifically concerned with an intravascular ultrasound image segmentation method for characterizing blood vessel vascular layers. The proposed image segmentation method for estimating boundaries of layers in a multi-layered vessel provides image data which represent a plurality of image elements of the multi-layered vessel. The method also determines a plurality of initial interfaces corresponding to regions of the image data to segment and further concurrently propagates the initial interfaces corresponding to the regions to segment. The method thereby allows to estimate the boundaries of the layers of the multi-layered vessel by propagating the initial interfaces using a fast marching model based on a probability function which describes at least one characteristic of the image elements.

The present invention relates to a new intravascular ultrasound imaging device with an increased field of view. By using more than one ultrasound transducer crystal that is capable of producing an ultrasonic signal for imaging, and preferably aligning the individual crystals on a shared backing with at least one edge of the crystals in contact, the field of view generated by a given actuator mechanism is increased without substantially increasing the overall dimensions of the device. Also disclosed are methods of using the same.

A design and a fabrication method for an intravascular imaging and therapeutic catheters for combined ultrasound, photoacoustic, and elasticity imaging and for optical and / or acoustic therapy of hollow organs and diseased blood vessels and tissues are disclosed in the present invention. The invention comprises both a device—optical fiber-based intravascular catheter designs for combined IVUS / IVPA, and elasticity imaging and for acoustic and / or optical therapy—and a method of combined ultrasound, photoacoustic, and elasticity imaging and optical and / or acoustic therapy. The designs of the catheters are based on single-element catheter-based ultrasound transducers or on ultrasound array-based units coupled with optical fiber, fiber bundles or a combination thereof with specially designed light delivery systems. One approach uses the side fire fiber, similar to the one utilized for biomedical optical spectroscopy. The second catheter design uses the micro-optics in the manner of a probe for optical coherent tomography.

A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

An optic fiber adapted for ultrasound imaging of the lumen of a vessel comprising: an inner core for transmitting light having an index of refraction that changes responsive to acoustic energy incident thereon; a ring core concentric with the inner core for transmitting light; a cladding material between the inner and ring cores that has an index of refraction smaller than the index of refraction of the material from which the inner core is formed; and at least one acoustic transducer comprising absorbing material formed on the surface of the ring core that absorbs optical energy transmitted along the ring core and generates ultrasound responsive thereto.

The present invention generally relates to intravascular ultrasound (IVUS) image segmentation methods, and is more specifically concerned with an intravascular ultrasound image segmentation method for characterizing blood vessel vascular layers. The proposed image segmentation method for estimating boundaries of layers in a multi-layered vessel provides image data which represent a plurality of image elements of the multi-layered vessel. The method also determines a plurality of initial interfaces corresponding to regions of the image data to segment and further concurrently propagates the initial interfaces corresponding to the regions to segment. The method thereby allows to estimate the boundaries of the layers of the multi-layered vessel by propagating the initial interfaces using a fast marching model based on a probability function which describes at least one characteristic of the image elements.

Embodiments of invention are directed to devices, and methods of forming them, that can be used for imaging interior volumes of the body. Particular embodiments are directed to improved intravascular ultrasound devices. In some embodiments the intravascular ultrasound devices are intended to be ‘forward-looking’; i.e., the image obtained by the device is of structures in front of, or distal to, the device.

It is described a virtual pullback as a visualization and quantification tool that allows an interventional cardiologist to easily assess stent expansion. The virtual pullback visualizes the stent and / or the vessel lumen similar to an Intravascular Ultrasound (IVUS) pullback. The virtual pullback is performed in volumetric data along a reference line. The volumetric data can be a reconstruction of rotational 2D X-ray attenuation data. Planes perpendicular to the reference line are visualized as the position along the reference line changes. This view is for interventional cardiologists a very familiar view as they resemble IVUS data and may show a section plane through a vessel lumen or a stent. In these perpendicular section planes automatic measurements, such as minimum and maximum diameter, and cross sectional area of the stent can be calculated and displayed. Combining these 2D measurements allows also volumetric measurements to be calculated and displayed.

A method and system for generating stabilized intravascular ultrasonic images are provided. The system may include a probe instrument, such as a catheter, connected to a processor and a post-processor. The method of using the system to stabilize images and the method for stabilizing images involve the process by which the processor and post-processor stabilize the image. A computer readable medium containing executable instructions for controlling a computer containing the processor and post-processor to perform the method of stabilizing images is also provided. The probe instrument, which has a transmitter for transmitting ultrasonic signals and a receiver for receiving reflected ultrasonic signals that contain information about a tubular environment, such as a body lumen, preferably is a catheter. The processor and post-processor are capable of converting inputted signals into one or more, preferably a series of, images and the post-processor, which determines the center of the environment at each reflection position, detects the edges of the tubular environment and aligns the image center with the environment center thereby limiting the drift of images, which may occur due to movement of the environment, and stabilizing the images. The processor may also be programmed to filter images or series of images to improve the image stabilization and remove motion interference and / or may be programmed to extract the 3D shape of the environment. The method and device are of particular use where motion causes image drift, for example, the imaging a body lumen, in particular a vascular lumen, where image drift may occur due to heart beat or blood flow.

A method for segmenting intravascular images includes acquiring a series of digitized images acquired from inside a vessel, each said image comprising a plurality of intensities corresponding to a 2-dimensional grid of pixels, providing a precomputed set of shapes for modeling contours of vessel wall boundaries, wherein a contour can be expressed as a sum of a mean shape and a inner product of shape modes and shape weights, initializing a boundary contour for one of said set of images, initializing said shape weights by projecting a contour into said shape modes, updating said shape weights from differential equations of said shape weights, and computing a contour by summing said mean shape and said inner product of shape modes and updated shape weights.

The invention relates to a medical investigation and / or treatment system comprising:a catheter system, comprising a catheter (1, 7, 9), witha first sensor (4, 11) of an imaging system for optical coherence tomography with an optical fiber via which the light is directed and is radiated in the area of a catheter tip introduced into an area to be investigated, via which fiber reflection light is directed from an illuminated investigation area to a first image processing unit (22),a second sensor (3, 8, 10) of an intravascular ultrasound imaging system to transmit and receive sound pulses which are fed as an electrical signal to a second image processing unit (23), undat least one display unit (24) for presenting the images of the first and second image processing unit (22, 23).

An intravascular catheter device having a catheter and an ultrasound ablation manifold is proposed for generating cavitations and acoustic jet streams in the blood to ablate atheroma. The ablation manifold has a power transducer and a coupled leaky acoustic cavity. The leaky acoustic cavity contains a first portion of ultrasonic power emission for intra-cavity ablation while allowing a second portion of ultrasonic power emission to leak outside for an extra-cavity ablation. The power transducer and the leaky acoustic cavity are configured to form a confocal resonant cavity. An intervening bird cage is coupled to the resonant cavity for stronger resonance while maintaining ultrasound leakage. A protective shield is mounted around the waist of bird cage to strengthen resonance and to prevent damaging the intima from an otherwise normal incidence of high intensity ultrasound. A microbubble releasing device and micro pump are also included to further increase the ablation efficacy.

A method and system for co-registration of angiography data and intra vascular ultrasound (IVUS) data is disclosed. A vessel branch is detected in an angiogram image. A sequence of IVUS images is received from an IVUS transducer while the IVUS transducer is being pulled back through the vessel branch. A fluoroscopic image sequence is received while the IVUS transducer is being pulled back through the vessel branch. The IVUS transducer and a guiding catheter tip are detected in each frame of the fluoroscopic image sequence. The IVUS transducer detected in each frame of the fluoroscopic image sequence is mapped to a respective location in the detected vessel branch of the angiogram image. Each of the IVUS images is registered to a respective location in the detected vessel branch of the angiogram image based on the mapped location of the IVUS transducer detected in a corresponding frame of the fluoroscopic image sequence.

The present invention provides low profile intravascular ultrasound catheters adapted to access sites within the patient's body through narrow blood vessels, e.g., the radial artery. In an embodiment, a low profile catheter comprises an catheter sheath, a short guidewire receiver attached to the distal end of the catheter sheath, and a telescope assembly at the proximal end. The catheter sheath comprises a main portion and a tapered portion for increased flexibility toward the distal end of the catheter. In one embodiment, a rotatable and translatable imaging core is received within the catheter sheath for ultrasound imaging. A short guidewire receiver is used to allow the imaging core to be advanced farther distally with respect to the distal end of the catheter. In an embodiment, the catheter sheath extends through a portion of the telescope assembly to provide enhanced support of the imaging core within the telescope assembly.

Methods related to delivery of various heart valve implants are described. The implant may be delivered using an ultrasound imaging delivery system. The ultrasound imaging delivery system may be used to deliver a variety of different devices, including mitral valve reshaping devices, mitral valve replacement valves, and others. A deployment catheter carrying an implant having a tissue anchor is advanced to a deployment site in a heart. An imaging element is positioned adjacent the implant and a relationship between the tissue anchor and an anatomical landmark in the heart is visualized. The implant is then attached by driving the tissue anchor into tissue in the heart.

The invention relates to a medical system for introducing a catheter into a blood vessel of a patient, having a computer and control unit, a means for creating a transparent general view of the position of the vessel, a catheter with a reversible inflatable balloon located in the front area, to the outside of which a stent can be fitted for implanting into the vessel, a position locating system for the catheter with position and location sensors that can determine the position and location of the catheter, the system with at least one OCT (optical coherence tomography) sensor at a catheter end for the close-up area, with at least one IVUS (intravascular ultrasound) imaging sensor at a catheter end for the remote area and the computer and control unit having image processing and image display functions for the image sensors.

A method and system for generating stabilized intravascular ultrasonic images are provided. The system includes a probe instrument, having an ultrasonic signal transmitter and a reflected ultrasonic signal receiver, the reflected signals containing information about a tubular environment, and a processor and post-processor, capable of converting inputted signals into one or more, preferably a series of, images. The method for stabilizing images involves the processor and post-processor input and output. The post-processor determines the environment center at each reflection position, detects the tubular environment edges, and aligns the image center with the environment center thereby limiting image drift and stabilizing the images. The processor may also filter images to improve image stabilization and remove motion interference and / or extract the environment's 3D shape. The method and device are of particular use in a vascular lumen, where image drift may occur due to heart beat or blood flow.

An ultrasound catheter is described herein for insertion into a cavity such as a blood vessel to facilitate imaging within a vasculature. The catheter comprises an elongate flexible shaft, a capacitive microfabricated ultrasonic transducer, and a sonic reflector. The elongate flexible shaft has a proximate end and a distal end. A capacitive microfabricated ultrasonic transducer (cMUT) is mounted to the shaft near the distal end. The reflector is positioned such that a reflective surface redirects ultrasonic waves to and from the transducer. In other embodiments, the catheter comprises a plurality of cMUT elements and operates without the use of reflectors. In further embodiments, integrated circuitry is incorporated into the design.

The invention relates to an intravascular ultrasound image and intravascular-OCT image fusing method. The method includes the following steps of (a) image retrieval, wherein for intravascular ultrasound (IVUS) images and intravascular (IV)-OCT images collected at the same position on a blood vessel section, a frame of IV-OCT image is taken as a reference image, and an image to be registered is selected from the n frames of IVUS images collected from the point; (b) IVUS image and IV-OCT image registration; (c) IVUS image and IV-OCT image fusion. IV-OCT image data and IVUS image data of the same blood vessel section are fused, the advantage of high tissue penetrating power of IVUS imaging and the advantage of high resolution of IV-OCT imaging are brought into full play, more comprehensive description of blood vessel walls and atherosclerotic plaques is obtained, and a reliable basis is provided for research on the coronary heart disease and the like.

The invention discloses a method for intravascular ultrasound multi-slice shear wave elastography. The method comprises the following steps of recording an original ultrasound echo signal of a tissue to be detected; enabling an interventional ultrasound array probe to generate acoustic radiation force by virtue of a short-pulse signal controlled by a computer; emitting ultrasonic pulse beams for many times to accept and detect a propagation process of shear waves generated by the acoustic radiation force; analyzing the propagation speed of the shear waves in the tissue to be detected to obtain a wave speed distribution image of the shear waves in the tissue; performing wave speed mapping on the shear waves at each position in the tissue to be detected to obtain a quantitative elastic image of the intravascular tissue. The method has the advantages of real time performance, quantification, high speed, high resolution and the like; a multi-array element intravascular transducer array is used for performing vascular wall tissue elastic information quantitative analysis to excite and track the shear waves; the further popularization and application of intravascular elastography are favorably promoted, and the early diagnosis capability of people in cardiovascular diseases is enhanced.

Methods related to delivery of various heart valve implants are described. The implant may be delivered using an ultrasound imaging delivery system. The ultrasound imaging delivery system may be used to deliver a variety of different devices, including mitral valve reshaping devices, mitral valve replacement valves, and others. A deployment catheter carrying an implant having a tissue anchor is advanced to a deployment site in a heart. An imaging element is positioned adjacent the implant and a relationship between the tissue anchor and an anatomical landmark in the heart is visualized. The implant is then attached by driving the tissue anchor into tissue in the heart.

The invention discloses a vascular four-dimensional reconstruction method in a NOT gate-controlled ICUS (intravascular ultrasound) image sequence. The method comprises the following steps: accurately positioning an ultrasonic catheter retracement path by utilizing a pair of approximate orthorhombic CAG (chronic atrophic gastritis) image sequences collected with an ICUS image synchronously; carrying out four-dimensional reconstruction on a morphological structure of a target vessel section containing possibly existing plaques through combining the cross section information of a vessel lomen extracted from the ICUS image; and reproducing true forms of coronary vessels at each time phase in a cardiac cycle. With the adoption of the vascular four-dimensional reconstruction method in the NOT gate-controlled ICUS image sequence, the four-dimensional reconstruction of the morphological structure of a coronary artery target vessel section containing the possibly existing plaques is realized, the true forms of the target vessel section at different time phases in the cardiac cycle can be comprehensively and truly reflected; and more reliable accordance can be provided for clinical diagnosis and treatment of coronary arteriesarteriosclerosis osteolytic lesions and research of biomechanical characteristics of coronary artery vascular tissues and the like. The method does not need an ECG-gating acquisition device, and also does not need ECG signals, so that the interventional examination time is greatly shortened, and the requirements on the original image data are reduced.