Patents

Literature

Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.

57 results about "Tropoelastin" patented technology

Filter

Efficacy Topic

Property

Owner

Technical Advancement

Application Domain

Technology Topic

Technology Field Word

Patent Country/Region

Patent Type

Patent Status

Application Year

Inventor

Tropoelastin is a water-soluble molecule with a molecular weight of approximately 72,000 daltons. Multiple tropoelastin molecules covalently bind together with crosslinks to form the protein elastin that is very prevalent in the body. There is only one gene for this molecule and so only one protein. However, occasional splicing provides tissue specificity. There are 36 small domains in Tropoelastin and each weighs about 2 kilodaltons. Within the exons, there is alternating hydrophobic and Lysine-rich domains, this is important in forming Elastin. Tropoelastin does not undergo cleavage and forming the microfibril is achieved by a self-association process termed coacervation.

Method for using tropoelastin and for producing tropoelastin biomaterials

InactiveUS7001328B1Reduce needTubular organ implantsProsthesisVeinCatheter

It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue using tropoelastin, preferably crosslinked tropoelastin and specifically to provide a tropoelastin biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The tropoelastin biomaterial itself can also be used as a stent or conduit covering or coating or lining.

Method for using tropoelastin and for producing tropoelastin biomaterials

Method for using tropoelastin and for producing tropoelastin biomaterials

Method for using tropoelastin and for producing tropoelastin biomaterials

Owner:GREGORY KENTON W +2

Elastin protective polyphenolics and methods of using the same

ActiveUS20090110709A1Prevent premature proteolyticEfficient elastogenesisCosmetic preparationsBiocideFiberPolyphenol

Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and / or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and / or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Owner:ELASTOGENESIS LLC +1

Method for using tropoelastin and for producing tropoelastin biomaterials

InactiveUS20070005148A1Reduce needTissue cultureTubular organ implantsVeinInsertion stent

It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue using tropoelastin, preferably crosslinked tropoelastin and specifically to provide a tropoelastin biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The tropoelastin biomaterial itself can also be used as a stent or conduit covering or coating or lining.

Method for using tropoelastin and for producing tropoelastin biomaterials

Method for using tropoelastin and for producing tropoelastin biomaterials

Method for using tropoelastin and for producing tropoelastin biomaterials

Owner:BAROFSKY ANDREW D +1

Compositions and methods for treating signs of skin aging

ActiveUS20100215785A1BiocideCosmetic preparationsTropoelastinDermatology

The invention relates to methods and compositions for treating skin aging, said compositions comprising at least one tropoelastin promoter and at least one tropoelastin crosslinker.

Owner:JOHNSON & JOHNSON CONSUMER COPANIES

Methods for assessing emphysema

InactiveUS20060211026A1Microbiological testing/measurementBiological testingSLPICXCL2

Emphysema and COPD are diagnosed, and the efficacy of therapeutic drug candidates for the treatment of emphysema and / or COPD is evaluated, by determining biomarkers selected from the group SpB, desmosine, VEGF, IGFBP2, MMP12, TIMP1, MMP9, Crabp2, Rbp1, Cyp26a1, Tgm2, Timp3, Adam17, Serpina1, Slpi, Col1a1, Eln, TGFβ1, TGFβ-RII, Sftpa1, Csf2, Cxcl1, Cxcl2, Cxcl5, IL-8Rβ, IL-8Rα, IL-6, TNF, EGF-R, Areg, PDGFα, HpGF, FGF7, Kdr, flt1, Angpt1, Tek, HIF1α, Hyou1, PGF, and tropoelastin.

Methods for assessing emphysema

Methods for assessing emphysema

Owner:ROCHE PALO ALTO LLC

Tropoelastin-based protoelastin biomaterials

ActiveUS7700126B2Improve adhesionFibrinogenPeptide/protein ingredientsPolymer substrateMedicine

Biocompatible materials suitable for use in vascular applications have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal, bone, ceramic or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer. The flexibility in engineering and design makes protoelastin biomaterials suited not only to the production of conduits but any number of other vascular applications that require blood contacting surfaces. Tropoelastin and the subsequently engineered biomaterial protoelastin provide the opportunity to satisfy a large unmet need for a biocompatible material adaptable enough to meet a range of diverse vascular uses. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells.

Tropoelastin-based protoelastin biomaterials

Tropoelastin-based protoelastin biomaterials

Tropoelastin-based protoelastin biomaterials

Owner:NG MARTIN KEAN CHONG +2

COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER

InactiveUS20110081430A1High activityGood curative effectCosmetic preparationsBiocideTropoelastinDermatology

The present invention relates to a composition comprising an NFκB-inhibitor and a tropoelastin promoter, and methods of treating signs of skin aging using said compositions.

COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER

COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER

COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER

Owner:JOHNSON & JOHNSON CONSUMER COPANIES

Chemically and biologically modified medical devices

ActiveUS20100174351A1Increased protease resistanceSignificantly reducedStentsBone implantBiocompatibility TestingThrombus

Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.

Chemically and biologically modified medical devices

Chemically and biologically modified medical devices

Chemically and biologically modified medical devices

Owner:NG MARTIN KEAN CHONG +3

Tropoelastin-based protoelastin biomaterials

ActiveUS20080107708A1Improve adhesionFibrinogenPeptide/protein ingredientsMedicinePolymer substrate

Biocompatible materials suitable for use in vascular applications have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal, bone, ceramic or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer. The flexibility in engineering and design makes protoelastin biomaterials suited not only to the production of conduits but any number of other vascular applications that require blood contacting surfaces. Tropoelastin and the subsequently engineered biomaterial protoelastin provide the opportunity to satisfy a large unmet need for a biocompatible material adaptable enough to meet a range of diverse vascular uses. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells.

Tropoelastin-based protoelastin biomaterials

Tropoelastin-based protoelastin biomaterials

Tropoelastin-based protoelastin biomaterials

Owner:NG MARTIN KEAN CHONG +2

Biocompatible coatings for medical devices

ActiveUS20090169714A1Material nanotechnologyLiquid spraying plantsMedicineBiocompatible coating

Biocompatible coatings for implantable medical devices are disclosed. Embodiments of the invention provide methods for coating an object with a biocompatible coating wherein the device is suspended using a flowing gas during the coating process. Embodiments of the invention provide tropoelastin coatings and methods of creating tropoelastin coatings for implantable medical devices. Optionally, the biocompatible coating can be a drug eluting coating.

Biocompatible coatings for medical devices

Biocompatible coatings for medical devices

Biocompatible coatings for medical devices

Owner:INTEL CORP

Use of tropoelastin for repair or restoration of tissue

ActiveUS20100021440A1Cosmetic preparationsBiocideTissue repairMedicine

The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin having an alkaline pH to form an elastic material from the tropoelastin in the solution. Also disclosed are elastic materials prepared according to this process and their applications.

Use of tropoelastin for repair or restoration of tissue

Owner:APTALIS PHARMA

Use of tropoelastin for repair or restoration of tissue

ActiveUS8101717B2Cosmetic preparationsBiocideTissue repairMedicine

The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin having an alkaline pH to form an elastic material from the tropoelastin in the solution. Also disclosed are elastic materials prepared according to this process and their applications.

Use of tropoelastin for repair or restoration of tissue

Owner:APTALIS PHARMA

Bioelectric blood pressure management

ActiveUS20190022396A1Increase elasticityPromote protein releaseElectrotherapyMedical devicesFiberSide effect

Described are a system and method that utilize bioelectric signaling to balance electrical potentials in a subject's body via neuro-hormonal circuit loops, to increase elasticity of the subject's arteries to promote protein release to dampen arterial blood pressure, and to change arterial electrical charges to reduce narrowing of the arteries. The described system is designed to localize and stimulate the fibers inside the vagus nerve without inadvertent stimulation of non-baroreceptive fibers causing side effects like bradycardia and bradypnea. The system also controls release of specific proteins known to lower blood pressures including tropoelastin (known to increase elasticity in the aorta and other peripheral blood vessels).

Bioelectric blood pressure management

Bioelectric blood pressure management

Bioelectric blood pressure management

Owner:LEONHARDT VENTURES LLC

Gelatin/Elastin Composites for Peripheral Nerve Repair

ActiveUS20190070338A1Strong adhesionImprove ductilitySurgeryTissue regenerationCellular componentPeripheral neuron

Neurosupportive materials that possess strong tissue adhesion were synthesized by photocrosslinking two polymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted tropoelastin (MeTro). The engineered materials exhibited tunable mechanical properties by varying the GelMA/MeTro ratio. In addition, GelMA/MeTro hydrogels exhibited 15-fold higher adhesive strength to nerve tissue ex vivo compared to traditionally used fibrin-based materials. Furthermore, the composites were shown to support Schwann cell (SC) viability and proliferation, as well as neurite extension and glial cell participation in vitro, which are essential cellular components for nerve regeneration. Finally, subcutaneously implanted GelMA/MeTro hydrogels exhibited slower degradation in vivo compared with pure GelMA, indicating its potential to support the growth of slowly regenerating nerves. Thus, GelMA/MeTro composites may be used as clinically relevant biomaterials to regenerate nerves and reduce the need for microsurgical suturing during nerve reconstruction.

Gelatin/Elastin Composites for Peripheral Nerve Repair

Gelatin/Elastin Composites for Peripheral Nerve Repair

Gelatin/Elastin Composites for Peripheral Nerve Repair

Owner:NORTHEASTERN UNIV

Chemically and biologically modified medical devices

ActiveUS8808365B2Peptide/protein ingredientsBone implantThrombusBiocompatibility Testing

Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.

Chemically and biologically modified medical devices

Chemically and biologically modified medical devices

Chemically and biologically modified medical devices

Owner:NG MARTIN KEAN CHONG +3

Elastin protective polyphenolics and methods of using the same

ActiveUS7566693B2Efficient elastogenesisBiocidePeptide/protein ingredientsFiberPolyphenol

Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and / or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and / or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Owner:ELASTOGENESIS LLC +1

Preparation and/or formulation of proteins cross-linked with polysaccharides

ActiveCN103384537ACosmetic preparationsSenses disorderCross-linkMonomer

Therapeutic compositions and/or formulations are provided, comprising: at least one cross-linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.

Preparation and/or formulation of proteins cross-linked with polysaccharides

Preparation and/or formulation of proteins cross-linked with polysaccharides

Preparation and/or formulation of proteins cross-linked with polysaccharides

Owner:APTALIS PHARMA

Elastin protective polyphenolics and methods of using the same

ActiveUS8114829B2Efficient elastogenesisBiocideOrganic active ingredientsFiberPolyphenol

Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and / or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and / or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Owner:THE UNIV OF TORONTO THE HOSPITAL FOR SICK CHILDREN & DEPT OF LAB MEDICINE & PATHOBIOLOGY +1

In Vivo Synthesis of Elastic Fiber

InactiveUS20140235547A1Minimizing degenerationFunction increaseCosmetic preparationsOrganic active ingredientsIn vivoTropoelastin

Disclosed herein are methods of restoring elasticity in tissue using tropoelastin containing compositions.

In Vivo Synthesis of Elastic Fiber

In Vivo Synthesis of Elastic Fiber

In Vivo Synthesis of Elastic Fiber

Owner:APTALIS PHARMA

Tropoelastin derivatives

InactiveUS7193043B1Connective tissue peptidesSugar derivativesCross-linkCombinatorial chemistry

The disclosure relates to derivatives of tropoelastin and variants of those derivatives. The disclosure further provides expression products and hybrid molecules of the derivatives and variants of the invention. Methods for the production of the derivatives, variants, expression products and hybrid molecules are described. Formulations, cross-linked structures and implants comprising the derivatives, variants, expression products and hybrid molecules of the invention are included. Uses of the derivatives, variants, expression products and hybrid molecules are further provided.

Tropoelastin derivatives

Tropoelastin derivatives

Tropoelastin derivatives

Owner:APTALIS PHARMA +1

Injectable Biomaterials

ActiveUS20120003283A1Powder deliveryConnective tissue peptidesTissue repairInjectable biomaterial

Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysaccharide derivative, in an amount effective for providing the substance with the properties of flow, enabling injection.

Injectable Biomaterials

Injectable Biomaterials

Injectable Biomaterials

Owner:APTALIS PHARMA

Biocompatible coatings for medical devices

ActiveUS8551555B2Material nanotechnologyLiquid spraying plantsBiocompatible coatingTropoelastin

Biocompatible coatings for implantable medical devices are disclosed. Embodiments of the invention provide methods for coating an object with a biocompatible coating wherein the device is suspended using a flowing gas during the coating process. Embodiments of the invention provide tropoelastin coatings and methods of creating tropoelastin coatings for implantable medical devices. Optionally, the biocompatible coating can be a drug eluting coating.

Biocompatible coatings for medical devices

Biocompatible coatings for medical devices

Biocompatible coatings for medical devices

Owner:INTEL CORP

Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression

InactiveUS8367619B2Promoting elastogenesisPeptide/protein ingredientsSkeletal disorderChondroitin sulphateExon

Compositions and methods are provided for promoting elastin fiber formation (elastogenesis) in a cell, including methods that comprise contacting a cell that is capable of elastogenesis with (i) a mutated biglycan polypeptide that lacks chondroitin sulphate proteoglycan chains, (ii) a versican V3 isoform polypeptide that lacks most or all of the polypeptide regions encoded by one or more of exons 4, 5 or 6 or by exons 9-10 or 11-13, and / or with (iii) metastatin.

Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression

Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression

Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression

Owner:BENAROYA RES INST AT VIRGINIA MASON

Elastin protective polyphenolics and methods of using the same

ActiveUS20100016417A1Prevent premature proteolyticEfficient elastogenesisBiocidePeptide/protein ingredientsFiberSkin elasticity

Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Owner:THE UNIV OF TORONTO THE HOSPITAL FOR SICK CHILDREN & DEPT OF LAB MEDICINE & PATHOBIOLOGY +1

Method for producing collagen elastin vermicelli

InactiveCN101467694AImprove water storage capacityImprovement ingredientsFood preparationWrinkle skinHydroxyproline

The invention provides a preparation method for collagen elastin silk noodle, relating to the preparation method for healthcare food, which is characterized in that the food is prepared by the steps of selecting materials, washing, undergoing acid and alkali treatment, boiling, chopping, puffing, shaping, drying, preparing into product, packing and sterilizing. The product has the beneficial effects of time and labor saving, full utilization of large amount of pork skin resources and industrial treatment. The product has general equilibrium nutritionally, and the preparation of which agrees with the nation-specified sanitary standards. In addition, the product contains five times higher of protein than pork. The combination of the praline and hydroxyproline in the collagen with the water in human skin can improve the water storage capability of the cell tissues with low water storage, improve the contents of the cell tissues, bringing delicateness and whiteness to human skin, reducing wrinkles, delaying senility, strengthening the elasticity of the blood vessel, and preventing cardiovascular diseases. Therefore the product is an ideal healthcare product for everybody to be beautiful and thin.

Owner:TIANJIN ZHONGYING HEALTH FOOD

Scalable Three-Dimensional Elastic Construct Manufacturing

ActiveUS20160067741A1Cosmetic preparationsConnective tissue peptidesTissue repairTropoelastin

The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin to form an elastic material from the tropoelastin in the solution. Also disclosed are elastic materials prepared according to this process and their applications.

Scalable Three-Dimensional Elastic Construct Manufacturing

Scalable Three-Dimensional Elastic Construct Manufacturing

Scalable Three-Dimensional Elastic Construct Manufacturing

Owner:APTALIS PHARMA

Materials and methods relating to cardiovascular imaging

InactiveCN103491983AIn-vivo radioactive preparationsGeneral/multifunctional contrast agentsPharmaceutical drugNuclear medicine

The invention provides conjugates for imaging plaques, such as cardiovascular plaques, as well as associated pharmaceutical compositions. Other aspects of the invention include methods for administering and imaging such conjugates and compositions, and using the imaging to characterise plaques. The conjugates of the invention distinguish between tropoelastin and elastin in plaques. The presence of tropoelastin can act as an indication that a plaque is liable to rupture or erode. Such information allows assessment of disease progression and response to treatment.

Materials and methods relating to cardiovascular imaging

Materials and methods relating to cardiovascular imaging

Materials and methods relating to cardiovascular imaging

Owner:伦敦王室学院

Elastin protective polyphenolics and methods of using the same

ActiveUS8642578B2Efficient elastogenesisPowder deliveryBiocideFiberPolyphenol

Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and / or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and / or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Elastin protective polyphenolics and methods of using the same

Owner:ELASTOGENESIS LLC +1

Injectable biomaterials

ActiveCN102348464AConnective tissue peptidesPeptide/protein ingredientsInjectable biomaterialTissue repair

Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysaccharide derivative, in an amount effective for providing the substance with the properties of flow, enabling injection.

Injectable biomaterials

Injectable biomaterials

Injectable biomaterials

Owner:APTALIS PHARMA

Protease susceptibility II

InactiveUS20080058261A1BiocideFungiProteinase activityTropoelastin

The manipulation of the amino acid sequence of tropoelastin, particularly human tropoelastin, to modify its protease susceptibility is described. The modified tropoelastins include tropoelastin derivatives having modified protease susceptibility, peptidomimetic molecules which contain amino acid sequences which correspond to or incorporate the protease susceptible sequences of tropoelastin. Uses of these tropoelastin derivatives and peptidomimetic molecules are provided. Also provided are nucleic acid molecules and genetic constructs encoding the amino acid sequences of the derivatives and peptidomimetic molecules of the invention.

Protease susceptibility II

Protease susceptibility II

Protease susceptibility II

Owner:APTALIS PHARMA

Popular searches

Blood vessel Ureter Body tissue Protein C Tissue sections Artery Vascular stent Biomaterial Dermal fibroblast Chemistry

Who we serve

R&D Engineer
R&D Manager
IP Professional

Why Eureka

Industry Leading Data Capabilities
Powerful AI technology
Patent DNA Extraction

Social media

Try Eureka

PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap