The invention provides a design method of a robust transceiver in a multi-cell MIMO interference channel. The method comprises the steps of S1, setting an operation mode of the multi-cell MIMO interference channel, S2, defining the signal noise ratio of a single user or receiver, calculating the signal noise ratio of the kth user or receiver, S3, analyzing the influence of the channel statistic error to the signal noise ratio, deriving a mutually independent receiving beam forming vector, S4, when the channel has the statistic error, introducing a slack variable, converting a non-convex signal noise ratio optimization problem into a second-order cone programming problem, using the convex optimization algorithm to solve the robust transmission beam forming vector problem, S5, using the alternating optimization method to obtain the robust beam forming vector. The method has strong robustness to the statistic errors, each receiver only uses partial CSI to obtain the mutually independent beam forming vectors, the feedback cost is reduced, the bit error rate performance is guaranteed.