75 results about "Mycobacterium sp. e" patented technology

The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum. In particular, compounds are claimed in which, independently from each other, R<1> is bromo, p=1, R<2> is alkyloxy, R<3> is optionally substituted naphthyl or phenyl, q=1, R<4> and R<5> each independently are hydrogen, methyl or ethyl, R<6> is hydrogen, r is equal to 0 or 1 and R<7> is hydrogen. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.

The present invention relates to novel benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis or Francisella tulerensis by administering to the patient a benzimidazole derivative or a pharmaceutically acceptable salt thereof.

The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib)the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum. In particular, compounds are claimed in which, independently from each other, R1 is bromo, p=1, R2 is alkyloxy, R3 is optionally substituted naphthyl or phenyl, q=1, R4 and R5 each independently are hydrogen, methyl or ethyl, R6 is hydrogen, r is equal to 0 or 1 and R7 is hydrogen. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.

PCT No. PCT / RU97 / 00098 Sec. 371 Date Mar. 17, 1998 Sec. 102(e) Date Mar. 17, 1998 PCT Filed Apr. 2, 1997 PCT Pub. No. WO98 / 43982 PCT Pub. Date Aug. 10, 1998Biologically active substance on the basis of tetracyclicnitrogen heterocycles of pyrimidine row for treating tuberculosis, mycobacteriousis, viral diseases, infections caused by chlamydias, and also diseases which are accompanied by immunodeficiency, in particular malignant neoplasm, has high antimicrobial activity, in particular to strains of mycobacteria which are resistant to the prototype-isoniazid, and simultaneously possess antiviral activity (relative to herpes simplex viruses), antichylamidial activity and also stimulate production of endogenic interferons in organisms. It represents a derivative of 5-oxo-5H-[1]-benzopyrano-[5,6-b]-4-oxo-4H-[1,2]-pyrimido-1,4,5,6-tetrahydro-1,3-thiazine (1) of general formula(1). (I-X) where: R1-H or halogen; R2-H, or halogen, or nitro-group, or hydroxy-group or methoxy-group.

Micro-organisms, including fungi, viruses and bacteria such as Mycobacteria and / or fragments of micro-organisms such as cell wall components present in an aqueous liquid are captured to a solid surface by adding to the liquid a sufficient quantity of a water soluble polymer in the presence of the solid surface to displace the micro-organisms and / or fragments from the liquid to the solid surface. The surface may be provided by a bead. The water soluble polymer may be polyethyleneglycol or polyvinylpyrrolidone.

Disclosed herein are antimicrobial peptides with useful and / or superior properties such as specificity, resistance to degradation, antimicrobial activity, desirably low levels of hemolytic activity, and a therapeutic index against a broad range of microorganisms including gram-negative, gram-positive and acid-fast bacteria, fungi and other organisms. Also provided are pharmaceutical compositions comprising these peptides and methods of using such peptides to control microbial growth or to treat or reduce incidence of infections caused by such microorganisms. Also disclosed are peptides at least one or all amino acids in the D configuration. Compositions disclosed herein are useful in the treatment of bacterial, mycobacterial and / or fungal infections or for reducing microbial cell numbers or growth on surfaces or in materials.

The present invention is directed to a method for inactivation and / or extraction of acid-fast bacteria (e.g., mycobacteria or nocardia), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain acid-fast bacteria and suspending the test sample in a container containing ethanol and beads; (b) bead beating and / or vortexing the container to break up clumps and / or disrupt acid-fast bacteria cells in the container; and (c) subsequently incubating the suspension for at least about 3 minutes at room temperature to inactivate any acid-fast bacteria contained in the test sample. In accordance with the present invention, the test sample can subsequently be pelleted by centrifugation, resuspended with formic acid, acetonitrile added, and subjected to mass spectrometry for characterization and / or identification of the acid-fast bacteria.

In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence of the bacteria.

The invention discloses a mycobacterium sp. strain FJH0105-16 and a method for producing 20-hydroxy-23,24-bisnorchol-4-ene-3-one through fermentation of phytosterol with the strain. The stain is preserved in China General Microbiological Culture Collection Center on November 3, 2016, with an accession number of CGMCC No. 13234. The production method comprises the following steps: with the mycobacterium sp. strain FJH0105-16 as a bacterial strain, carrying out slant seed culture, primary seed culture and fermentation and transformation in a fermentation tank; then adding ethyl acetate for extraction; carrying out drying with anhydrous sodium sulfate; then removing a solvent under reduced pressure so as to obtain a crude 20-hydroxy-23,24-bisnorchol-4-ene-3-one product, wherein the mol yield of the crude product is no less than 71%; and subjecting the crude product to recrystallization so as to obtain a finished 20-hydroxy-23,24-bisnorchol-4-ene-3-one product, wherein the finished product has a purity of greater than 95%.

The invention belongs to the technical fields of bioelectrochemistry and biochip sensors and relates to an electrochemical biochip sensor array for mycobacterium tuberculosis 16SrDNA and for detecting mycobacterium tuberculosis and a preparing method thereof. Starting with molecular level detection of the mycobacterium tuberculosis 16SrDNA, Fe3O4@SiO2 composite nanometer particles and a nanometer Au structure material are adopted as mediators, a novel and functionalized nanometer electrochemical biochip superparamagnetism nano-detection microsphere sensor interface is designed, the mycobacterium tuberculosis is subjected to double enrichment extraction and purification detection, and the electrochemical biochip sensor array for rapidly detecting the mycobacterium tuberculosis is constructed. A clinical sample containing the mycobacterium tuberculosis is directly added into a magnetic reaction micropore. A mycobacterium tuberculosis 16SrDNA specific sequence can be subjected to double enrichment and biological stabilization through utilizing a capture probe labeled by the Fe3O4@SiO2 composite nanometer particles and a nanometer Au labeled detecting probe respectively. A high mycobacterium tuberculosis target molecule separating efficiency and high detection sensitivity are expected to be achieved by utilization of nano-detection microsphere superparamagnetism. In addition, target molecule "on-chip" separation is expected to be achieved through characteristics of the electrochemical biochip sensor array without the need of extra separating steps, thus largely simplifying operation procedures and shortening the detection time.

An anti acid-fast bacterial agent containing, as an active ingredient, a pyridonecarboxylic acid derivative represented by the following general formula (1), a salt thereof, or a hydrate thereof, which shows excellent antibacterial activity against Mycobacterium tuberculosis and atypical acid-fast bacteria and exhibits good pharmacokinetics and safety

The present invention includes a method of treating or preventing a disease or disorder such as a mycobacterial infection, a Gram-positive bacterium infection, a yeast infection, an inflammatory condition, an auto-immune disorder and / or a proliferative disorder in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of at least one compound of the invention, which includes clofazimine derivatives.

The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.

Provided herein are compositions and methods useful for the detection of MTB. In particular, provided herein are kits, reagents, reaction mixtures, and methods involving such for nucleic acid amplification and detection procedures, which specifically and sensitively detect MTB in samples.