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Antituberculous drug drug-resistance gene and screening method thereof

A technology for drug resistance genes and anti-tuberculosis drugs, applied in the field of genetic engineering, can solve the problems of complicated operation, high verification difficulty and high cost, and achieve the effects of simple operation, convenient use and promotion of development.

Inactive Publication Date: 2016-10-26
AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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Problems solved by technology

[0005] The object of the present invention is to provide an anti-tuberculosis drug resistance gene and a screening method thereof, aiming at solving the problem of high cost, cumbersome operation, low specificity and difficult verification in the existing Mycobacterium tuberculosis drug resistance target gene screening technology. high problem

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  • Antituberculous drug drug-resistance gene and screening method thereof
  • Antituberculous drug drug-resistance gene and screening method thereof
  • Antituberculous drug drug-resistance gene and screening method thereof

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Embodiment Construction

[0051] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0052] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0053] The anti-tuberculosis drug resistance genes of the embodiments of the present invention are: pks12, pks5, PPE34, Rv1978, Rv1847, hemK, PPE3, glyA1, PE_PGRS27, PE_PGRS19, Rv1520, Rv1505c, Rv2407, mmuM, vapB17, Rv3727, Rv3737;

[0054] The pks12 gene sequence is SEQ ID NO: 1; the pks5 gene sequence is SEQ ID NO: 2; the PPE34 gene sequence is SEQ ID NO: 3; the Rv1978 gene sequence is SEQ ID NO: 4; the Rv1847 gene sequence is SEQ ID NO: 5; The hemK gene sequence is SEQ ID NO: 6; th...

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Abstract

The invention discloses an antituberculous drug drug-resistance gene and a screening method thereof. The antituberculous drug drug-resistance gene is pks12, pks5, PPE34, Rv1978, Rv1847, hemK, PPE3, glyA1, PE_PGRS27, PE_PGRS19, Rv1520, Rv1505c, Rv2407, mmuM, vapB17, Rv3727 and Rv3737. The novel candidate drug target gene is provided for a further understanding of drug resistance mechanism of MDR / XDR mycobacterium tuberculosis and the therapy of MDR / XDR-TB.

Description

technical field [0001] The invention belongs to the technical field of genetic engineering, and in particular relates to an anti-tuberculosis drug resistance gene and a screening method thereof. Background technique [0002] A gene (genetic element) is a segment of DNA that has a hereditary effect. Genes support the basic structure and performance of life. It stores all the information about race, blood type, gestation, growth, and apoptosis process of life. The interdependence of environment and heredity plays an important role in the reproduction of life, cell division and protein synthesis and other important physiological processes. All life phenomena such as birth, growth, decline, disease, old age, and death of organisms are related to genes. It is also an internal factor that determines the health of life. Therefore, genes have dual attributes: materiality (way of existence) and informationality (fundamental attributes). People's understanding of genes is constan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11C12R1/32
CPCC12Q1/689C12Q2600/156
Inventor 陈玲林冲曹志敏兰远波王霄尚艳李娜娜刘梅石亚萍彭文峰刘倩倩马苗苗何月娟文强唐明美岳建博熊莲李瑜琴袁阳周为静刘权贤张建勇张泓
Owner AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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