36 results about "Heart defect" patented technology

A heart defect in the form of an hole is corrected by placing a patch over the hole. The patch is first attached to an uninflated balloon which is placed distally of the hole. The balloon is inflated with fluid and the patch is positioned upon the hole. After endothelialization the balloon is deflated and removed through a small hole in the patch. The small hole in the patch is closed by a purse string. During endothelialization the balloon is held in place by a disk or second balloon on the proximate side of the defect.

The invention relates to a medical self-expandable occlusion device for treating heart defects of a patient, especially for closing abnormal holes in the tissue. The occlusion device (1) can be inserted into the body of a patient by means of a catheter system in a minimally invasive manner. The occlusion device (1) consists of an interlaced structure (1) of thin threads, the interlaced structure (10) having a first shape during insertion of the occlusion device into the body of the patient, which shape can be previously determined, and a second shape in the implanted position of the occlusion device, which shape can be previously determined, the occlusion device in the first shape of the interlaced structure (10) being in a folded condition and in the second shape of the interlaced structure (10) being in an expanded condition. The aim of the invention is to provide an occlusion device which can be implanted in as gentle a manner possible for the patient. For this purpose, the threads of the interlaced structure (10) consist of a shape memory polymer composition so that the interlaced structure (10) is deformed under the effect of an external stimulus from a temporary shape to a permanent shape, the temporary shape being the first shape of the interlaced structure (10) and the permanent shape being the second shape of the interlaced structure (10).

The present invention is directed to a model for teaching or illustrating surgical and/or medical technique, and having a base component representing tissue or an organ and several components structured and arranged to be couplable to and detachable from the base component and/or to each other, to illustrate different positions of the components with respect to one another representing different phases in surgical and/or medical techniques.

A delivery apparatus for delivering a medical device to a heart defect by a catheter includes a second wire section having a first end securely connected to a first wire section. A connecting member is mounted to a second end of the second wire section and is connected to the medical device. The second wire section has a cross sectional area smaller than the first wire section. When the medical device is delivered to the heart defect and is seated in a deployed position occluding the heart defect after the catheter is retracted, the second wire section remains connected to the medical device to absorb interfering vibration from the heartbeat, avoiding the medical device from deviating from the deployed position.

This invention relates to the production of dual models of Congenital Heart Defects and Hypertrophic Cardiomyopathy with the use of mice which are genetically modified by transgenic (gene-knockout) techniques. The present invention produces knockout mice that show multiple cardiovascular malformations which will serve as a model of cardiovascular diseases for the screening of potential drugs against ventricular remodeling, malignant arrhythmias, primary pulmonary hypertension, and degenerative valvular diseases, and congenital heart disease.

A temporary closure device for heart defects comprises a disc-like net rack, wherein the disc-like net rack is integrally formed by weaving fine wires, the fine wires form a closure head in the middle of the bottom of the disc-like net rack, a connecting part is fixed at the tail end of the closure head, and the surface of the disc-like net rack is covered with a flow resisting film; the height of the disc-like net rack is 2-3 mm. After the temporary closure device is conveyed to a defect position, the disc-like net rack is unfolded and enabled to be located on the left side of the defect position, a steel conveying cable is pulled to enable the disc-like net rack to be tightly attached to the left side of the defect position, and the defect position is temporarily closed; then, physiological indexes of a patient can be tested. After a test ends, the steel conveying cable is pulled to contract the disc-like net rack. The disc-like net rack is temporarily closed in the defect position instead of being tightly clamped in the defect position, after the steel conveying cable is pulled, the disc-like net rack enters a long conveying sheath through the closure head, and picking is facilitated.

The invention discloses an occluder for a structural heart defect, comprising a tubular interlaced structure having a pitch that varies along an axial length of the occluder; a proximal element; a distal element; and an intermediate element extending between the proximal element and the distal element. According to one aspect, at least one transition section of the pitch, from a first pitch to a second pitch, is located closer to the intermediate element of the occluder than an outer circumference of at least one of the proximal elements and the distal element when the occluder is in a relaxed state. According to another aspect, the occluder is extendible from the relaxed state to an axially extended state wherein the load to extension ratio, measured in N/mm, provided by the occluder is less than about 0.75 when extended at least 2 mm.

The present invention provides diagnostic methods for detecting congenital heart defects, or increased risk thereof, based on the Nell1 gene, RNA and protein. The methods include obtaining a biological sample and assessing the presence of a mutation in the Nell1 gene, RNA or protein. The presence of a mutation in the Nell1 gene, RNA or protein can be assessed by determining the levels of Nell1 gene, RNA or protein in the biological sample. The present invention further provides therapeutic methods for treating congenital heart defects based on the Nell1 gene, RNA and protein.

The invention discloses a suturing device for a heart defect. A hauling rope is arranged in a transmission channel, the lower end portion of the transmission channel is hinged to rotary stitches, therotary stitches are connected with the hauling rope, so that the hauling rope drives the rotary stitches to be in positions which are parallel with the transmission channel or form a set angle with the transmission channel. Lead holes are formed close to two end portions of the rotary stitches, lower butt-joint devices are arranged in the lead holes respectively, an upper butt-joint device is arranged in the transmission channel, and the upper butt-joint device is connected with sutures. The lower ends of the lower butt joint devices at the two ends of the rotary pins are connected via a connecting line. The upper ends of the upper butt joint devices are connected with a pushing stitch, and a pushing device pushes the pushing stitch further to drive the upper butt-joint device to make lockjoint with the lower butt-joint devices. The suturing device is simple in the total structure, can be used to treat heart septal defect effectively via a complete interventional therapy, reduce secondary damage on a patient and further reduce the risk of treating the patient.

The present invention relates to a medical device (5) which is used for palliative treatment and/or treatment at every stage without developing pulmonary hypertension in patients who have increased pulmonary blood flow and pulmonary hypertension risk that are caused particularly by congenital heart diseases with left to right shunt and functional single ventricular diseases, in heart defects; also, to treat patients who have a congenital heart defect and transposition of large arteries.

The invention discloses a rapid anti-calcification processing method of a cardiac surgery autologous pericardium patch. The method comprises the following steps: (1) soaking the dirty layer of the autologous pericardium patch, which is taken down, by using a glutaraldehyde solution, and flattening by pressing; (2) soaking the pericardium patch in a first processing solution prepared from polyethylene glycol and a tris-hydrochloric acid buffer solution, and then rinsing with warm normal saline; (3) putting the pericardial patch into a second processing solution prepared from warm normal salineand a magnesium chloride solution, soaking and rinsing; and (4) trimming into a required shape to obtain the autologous pericardium patch for a heart defect repair operation. The method sequentially comprises the steps of flattening and shaping, polyethylene glycol tanning, magnesium ion impregnation and the like. All the steps are sequentially connected and cooperatively matched, so that the prepared autologous pericardium patch has a good anti-calcification effect, animal experiments and clinical application can effectively prevent the autologous pericardium patch from calcifying and losingpower after cardiac surgery, and the operation is simple and rapid.

The invention discloses a congenital heart defect (CHD)-related gene family with sequence similarity 71, member A (FAM71A) and an application thereof and in particular provides a method for detecting CHD susceptibility. The method comprises the step of detecting whether the gene FAM71A, transcript and/or protein of an individual undergo variations compared with the normal gene FAM71A, transcript and/or protein, wherein the individual is more likely to suffer from CHD than normal people if variations exist. The invention also discloses a corresponding detection kit, especially a prenatal diagnosis kit.