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108 results about "Galectin-3" patented technology

Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides.

Binding of galectin-3 by low molecular weight pectin

ActiveUS20110294755A1Reducing effective levelConsistent and accurate and highly reproducible molecular weightOrganic active ingredientsBiocideSerum igeBiological condition
Administration of low molecular weight (10,000-20,000 Daltons, or lower) pectins, particularly modified citrus pectins (MCP), like PectaSol-C reduces galectins-3 levels in vivo. Reduction of galectin-3 levels by MCP inhibits inflammation, inhibits fibrosis formation in organs and tissues, and inhibits cancer formation, progression, transformation and metastases. The reduction in circulating, serum and cellular galectin-3, inherently resulting from the administration of MCP, provides benefit over a spectrum of biological conditions, as evidenced by in vivo trials.
Owner:SONY COMPUTER ENTERTAINMENT INC +1

Composition comprising mesenchymal stem cells or culture solution of mesenchymal stem cells for the prevention or treatment of neural diseases

ActiveUS20110262393A1Neurocytoxicity caused by amyloid-beta is preventedPhosphorylation of tau protein in neurons is preventedBiocideNervous disorderDiseaseCulture fluid
Provided are a pharmaceutical composition for prevention and treatment of a neural disease including at least one selected from the group consisting of mesenchymal stem cells (MSCs), a culture solution of the MSCs, activin A, PF4, decorin, galectin 3, GDF15, glypican 3, MFRP, ICAM5, IGFBP7, PDGF-AA, SPARCL1, thrombospondin-1, WISP1, progranulin, IL-4, a factor inducing expression thereof, and any combination thereof, and a method therefor.
Owner:MEDIPOST

Method and kit for predicting cancer

The present invention relates to a method and a kit for diagnosing and / or predicting the occurrence of cancer or the risk of contracting a cancer by measuring the concentration of a cancer screening antigen(CSA) in blood, which changes before the occurrence of the cancer in a patient. The method of diagnosing or predicting the occurrence of cancer or the risk of contracting a cancer comprising the steps of: determining a concentration of galectin-3 in a blood sample by reacting the blood sample with a monoclonal antibody of the galectin-3; comparing the determined concentration of the galectin-3 with concentration of the galectin-3 in a blood sample of a normal human; and predicting the risk of contracting a cancer if the determined concentration is greater than the concentration of the galectin-3 in blood of the normal human.
Owner:HAE JONG WOO

Nucleic acids and polypeptides useful for diagnosing and treating complications of pregnancy

ActiveUS20060166277A1Diagnosing and effectively treatingSave maternalMicrobiological testing/measurementDisease diagnosisPregnancyUdp glycosyltransferase
Disclosed herein are methods for diagnosing or treating pregnancy related hypertensive disorders that include the use of a polypeptide or a nucleic acid encoding a polypeptide selected from the following: follistatin related protein, interleukin 8, inhibin A, VEGF-C, angiogenin, beta fertilin, hypothetical protein, leukocyte associated Ig-like receptor secreted protein, erythroid differentiation protein, adipogenesis inhibitory factor, corticotropin releasing factor binding protein, alpha-1 anti-chymotrypsin, insulin-like growth factor binding protein-5, CD33L, cytokine receptor like factor 1, platelet derived endothelial growth factor, lysyl hydroxylase isoform 2, stanniocalcin precursor, secreted frizzled related protein, galectin-3, alpha defensin, ADAM-TS3, cholecystokinin precursor, interferon stimulated T-cell alpha chemoattractant precursor, azurocidin, sperminine oxidase, UDP glycosyltransferase 2 family polypeptide B28, neurotrophic tyrosine kinase receptor 2, neutral endopeptidase, CDC28 protein kinase regulatory subunit 2, beta glucosidase, lanosterol synthase, calcium / calmodulin-dependent serine protein kinase, estrogen receptor-alternatively spliced transcript H, chemokine (CX3C motif) receptor 1, tyrosinase-related protein 1, hydoxy-delta-5-steroid dehyrogenase, dihydropyramidinase-like-4, and cytochrome P450-family 11.
Owner:BETH ISRAEL DEACONESS MEDICAL CENT INC

Novel Galactoside Inhibitor of Galectins

The present invention relates to a compound of the general formula (I): The compound of formula (I) is suitable for treating pulmonary fibrosis, such as Idiopathic pulmonary fibrosis in a mammal. Furthermore the present invention concerns a method of monitoring development or progression of pulmonary fibrosis in a human subject, a method of monitoring or predicting exacerbation of symptoms in a human subject with pulmonary fibrosis as well as a method for treatment of pulmonary fibrosis, such as Idiopathic pulmonary fibrosis in a human subject having a galectin-3 level indicative of pulmonary fibrosis or exacerbation of symptoms.
Owner:GALECTO BIOTECH

N-terminally truncated galectin-3 for use in treating cancer

There is provided a composition having an effective amount of N-terminally truncated galectin-3 in a pharmaceutically acceptable carrier. Also provided by the present invention is a method of treating cancer by administering to a patient in need of such treatment an effective amount of N-terminally truncated galectin-3 in a pharmaceutically acceptable carrier.
Owner:MANDALMED

Novel galactoside inhibitors of galectins

Compounds having an effect as i.a. galectin inhibitors, to the use of said compounds as a medicament, as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal, where in the galectin is preferably a galectin-3. The novel compounds are defined by the general formula:
Owner:GALECTO BIOTECH

Galectin-3 and statin therapy

InactiveUS20120029003A1Improve survivalReduce developmentBiocideNervous disorderEnzyme inhibitor3 hydroxy 3 methylglutaryl coenzyme a reductase
Described herein are materials and methods for predicting and monitoring a heart failure patient's physiological response to treatment with a statin. More specifically, the present invention relates to the endogenous protein galectin-3 and its use as a predictor of response to treatment with 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, or statins.
Owner:BG MEDICINE

Use of Galectin-3 to promote the re-epithelialization of wounds

Methods for the therapeutic treatment of epithelial wounds in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-3 protein and / or a galectin-7 protein are provided. Pharmaceutical compositions comprising a pharmaceutically suitable carrier or diluent and as an active agent a galectin-3 protein and / or a galectin-7 protein are also provided.
Owner:TRUSTEES OF TUFTS COLLEGE TUFTS UNIV

Method for preparing electrochemical sensor used for detecting concentration of galectin-3 in serum

The invention relates to a preparation method and application of an electrochemical sensor for detecting a blood concentration level of an insulin sensitivity reduction early diagnosis biomarker, namely galectin-3 (Gal-3), causing type II diabetes, and belongs to the technical field of electrochemical detection. The preparation method is characterized by comprising the following steps: respectively synthesizing an N-GNRs-Fe-MOFs@AuPNs sensor substrate modified nano composite material and an AuPt-MB nano composite signal material, enabling a detection antibody capable of being in specific binding to the Gal-3 to be mixed with the AuPt-MB composite material so as to prepare a biological signal probe; conjugating a Gal-3 specific capture antibody on a substrate platform modified by the N-GNRs-Fe-MOFs@AuPNs composite material so as to conveniently and specifically capture a target Gal-3; finally, performing specific binding on the Gal-3 as well as the detection antibody and the capture antibody, thereby obtaining the electrochemical sensor for detecting the blood concentration level of the Gal-3. The sensor is successfully used for detecting the Gal-3 in serum. The electrochemical sensor disclosed by the invention has the advantages of being high in sensitivity, high in specificity, rapid in detection and convenient. An early diagnostic basis is provided for insulin resistance causing the type II diabetes.
Owner:CHONGQING MEDICAL UNIVERSITY

Detection kit for galectin-3 and preparation method thereof

The invention discloses a detection kit for galectin-3 and a preparation method thereof. The detection kit comprises reagent I and reagent II which are independent of each other. Reagent I comprises a biobuffer, a coagulation accelerator, a preservative, a chelating agent, an inorganic salt and water; and reagent II comprises latex particles, the biobuffer, a surfactant, the preservative, a suspending agent, a blocking agent and water, wherein galectin-3 antibodies are coated by the latex particles. The latex particles with a particle size of 130 to 270nm are used for coating galectin-3 antibodies via chemical crosslinking, so that stability, sensitivity and relatively wide detection linear range of the detection kit are ensured. The detection kit possesses advantages such as excellent stability, high sensitivity and specificity, and convenient operation process; and is suitable for population and application.
Owner:WUHAN LIFE ORIGIN BIOTECH LTD

Sustained release N-terminally truncated galectin-3 and antibodies to galectin-3 carbohydrate ligands for use in treating disease

InactiveUS20050032673A1Promote multimerizationPrevents its cross-linking activityPeptide/protein ingredientsMammal lectinsDiseaseBinding site
There is provided a composition for anti-cancer or anti-inflammatory treatment having an effective amount of N-terminally truncated galectin-3 or its homologues, antibodies to galectin-3 carbohydrate binding sites, or a nucleic acid sequences encoding N-terminally truncated galectin-3 or its homologues, in a pharmaceutically acceptable carrier. Also provided by the present invention is a method of treating disease by administering to a patient in need of such treatment an effective amount of N-terminally truncated galectin-3, its homologues, antibody to galectin-3 carbohydrate binding sites, or a nucleic acid sequence encoding N-terminally truncated galectin-3 in a pharmaceutically acceptable carrier. Further, there is provided a disease treatment having an effective amount of N-terminally truncated galectin-3 or its homologues, antibodies to galectin-3 carbohydrate binding sites, or a nucleic acid sequences encoding N-terminally truncated galectin-3 or its homologues, in a pharmaceutically acceptable carrier.
Owner:MANDALMED

Colloidal gold test paper for rapidly and quantificationally detecting galectin-3

The invention discloses a piece of colloidal gold test paper for rapidly and quantificationally detecting galectin-3. The colloidal gold test paper comprises a support gasket 5 and a nitrocellulose membrane 1 on the support gasket, wherein one end of the nitrocellulose membrane is connected with a water absorption pad 4, and the other end of the nitrocellulose membrane is connected with a conjugate gasket 2; the conjugate gasket is connected with a sample gasket 3; a first fixing part 7 is arranged under the other end of the sample gasket, and a second fixing part 6 is arranged above the other end of the sample gasket. The colloidal gold test paper is characterized in that a detection line 8 in the middle of the nitrocellulose membrane 1 is coated with a Gal-3 antibody; two control lines 9 are arranged at the two sides of the detection line, respectively; the conjugate gasket 2 is coated with a gold labeled Gal-3 monoclonal antibody or polyclonal antibody and a control line conjugate.
Owner:RELIA BIOTECH SHENZHEN LTD

Galectin-3 and Cardiac Resynchronization Therapy

The present invention relates to materials and methods for monitoring and predicting a heart failure patient's physiological response to cardiac resynchronization therapy. More specifically, the present invention relates to the endogenous protein galectin-3 and its use in monitoring progression of disease in a patient undergoing cardiac resynchronization therapy, and as a predictor of response to cardiac resynchronization therapy.
Owner:BG MEDICINE

Nucleic acids and polypeptides useful for diagnosing and treating complications of pregnancy

InactiveCN101299962AMicrobiological testing/measurementDisease diagnosisAlpha defensinInsulin-like growth factor-binding protein
Disclosed herein are methods for diagnosing or treating pregnancy related hypertensive disorders that include the use of a polypeptide or a nucleic acid encoding a polypeptide selected from the following: follistatin related protein, interleukin 8, inhibin A, VEGF-C, angiogenin, beta fertilin, hypothetical protein, leukocyte associated Ig-like receptor secreted protein, erythroid differentiation protein, adipogenesis inhibitory factor, corticotropin releasing factor binding protein, alpha-1- anti-chymotrypsin, insulin-like growth factor binding protein-5, CD33L, cytokine receptor like factor 1, platelet derived endothelial growth factor, lysyl hydroxylase isoform 2, stanniocalcin precursor, secreted frizzled related protein, galectin-3, alpha defensin, ADAM-TS3, cholecystokinin precursor, interferon stimulated T-cell alpha chemoattractant precursor, azurocidin, sperminine oxidase, UDP glycosyltransferase 2 family polypeptide B28, neurotrophic tyrosine kinase receptor 2, neutral endopeptidase, CDC28 protein kinase regulatory subunit 2, beta glucosidase, lanosterol synthase, calcium / calmodulin-dependent serine protein kinase, estrogen receptor-alternatively spliced transcript H, chemokine (CX3C motif) receptor 1, tyrosinase-related protein 1, hydoxy-delta-5-steroid dehyrogenase, dihydropyramidinase-like-4, and cytochrome P450-family 11.
Owner:BETH ISRAEL DEACONESS MEDICAL CENT INC

Colorectal cancer marker galectin, method for analyzing galectin concentration in blood sample, and kit for detecting colorectal cancer marker galectin

InactiveUS20130065258A1High positive rateImprove patient capture rateBiological material analysisPeptide preparation methodsGalectin-3 AntibodyPrognostic prediction
The present invention provides a tumor screening marker that can be actually used in clinical practice to detect colorectal cancer, and a tumor progression marker that can complement CEA or CA19-9. Galectin-1 used as a tumor screening marker or a tumor progression marker for colorectal cancer. Galectin-3 used as a tumor screening marker. Galectin-4 used as a tumor progression marker, a tumor screening marker, or a prognostic prediction marker for colorectal cancer. A method of analyzing the galectin concentration in a collected blood sample using the galectin. A colorectal cancer marker detection kit comprising a detection antibody selected from the group consisting of a fluorescently labeled galectin-1 antibody, a fluorescently labeled galectin-3 antibody, and a fluorescently labeled galectin-4 antibody.
Owner:SHIMADZU CORP +1

Blood marker for diagnosing hepatic fibrosis and early cirrhosis

The invention discloses a blood marker for diagnosing hepatic fibrosis and early cirrhosis. The blood marker refers to galectin 3. The concentration of the galectin 3 in the blood is analyzed by using the blood marker through enzyme linked immune reaction so as to analyze and evaluate hepatic fibrosis and early cirrhosis. By using the blood as the detection sample, early diagnosis on hepatic fibrosis and early cirrhosis can be achieved conveniently and rapidly.
Owner:ANHUI SIZHENG MEDICAL TECH
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