A cruciform buckling restrained brace with transverse partition double-layered bushing is provided. The core steel brace has a cruciform cross section, and comprises a middle segment (buckling segment) as major body with a smaller width, two distal end segments (extension segments), a transition segment between the buckling segment and the extension segment, and a transverse partition arranged in the middle of the buckling segment. Outer restraining steel bushings are positioned respectively at two sides of the transverse partition. An inner steel bushing is arranged between the outer restraining steel bushing and the core steel brace and has a cruciform cross section. The space between the inner steel bushing and outer restraining steel bushing is packed with fillers. An anti-adhesion material is coated tightly on the surface of the buckling segment and transition segment of the core steel brace, with a gap between the anti-adhesion material and the inner steel bushing and filled with a compressible material. The invention has the advantages of simple structure, low fabrication cost, suitability for streamline production, and wide application in high-rise buildings, towering buildings, and highway and railway bridges. The invention helps to increase the structural rigidity, improve the capacity of energy dissipation of the whole structure, and prevent earthquake disaster.