The invention provides a comprehensive age detection system based on weighted kernel regression and packaged deviation search, which is characterized in that it includes: data acquisition equipment, actual age input equipment, memory, preprocessing module, feature compression module, traditional age estimation module, Pathological age estimation module, weighted kernel regression module and result output module. The effect is: the system overcomes the shortcomings of traditional age estimation methods and pathological age estimation methods, and effectively controls the actual age estimation error of normal people while improving the classification ability of estimated age. The algorithm principle of the whole framework is clear, easy to implement, more scientifically based on the detection of the age and health status of healthy people or patients, high reliability, and strong feasibility.