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A kind of bone repair material constructed by 3D printing and its preparation method

A 3D printing and bone repair technology, applied in the field of biomedical engineering materials, can solve the problems of easy collapse of bone materials, poor material stability, high printing temperature, and achieve the effect of ensuring mechanical strength and promoting osseointegration

Active Publication Date: 2021-12-14
GUANGZHOU FEISHENG HIGH POLYMER MATERIAL CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN 107469153A discloses a degradable composite bone repair material, by adding poly(adipic acid-succinic acid) butanediol copolyester (PBSA) to the polylactic acid and bone powder system, although its blend The toughness is improved, but once the composite material degrades faster than the new bone growth rate after implantation in the animal body, the bone material in the repaired area is prone to collapse, resulting in the failure of the repair of the bone defect area
Chinese patent CN109223248A discloses a skull prosthesis for inducing bone tissue regeneration and its preparation method. The cranial prosthesis includes an inner induction layer, a support layer and an outer induction layer from the inside to the outside; the support layer plays a supporting role, but This preparation method needs to first print the support layer through selective laser sintering 3D printing technology, and then embed the printed support layer structure in the bioactive material with the help of the upper and lower abrasive tools of the skull restoration. The process is prone to dimensional errors, which is not conducive to actual clinical needs
Chinese patent CN105031737A discloses a 3D printed digital artificial bone and its preparation method. The artificial bone is composed of cortical bone, cancellous bone and bone marrow cavity, and the porosity is 10% by printing L-polylactic acid or polyether ether ketone % cortical bone, while cancellous bone with a porosity of 60%-80% is printed by mixing poly-L-lactic acid and hydroxyapatite, but the cancellous bone is made of poly-L-lactic acid and hydroxyapatite at a ratio of 4:5 It is well known that when the content of inorganic particles is too high, the interface of the polymer material is damaged, the stability of the material is poor, and plugging or even collapse is prone to occur during the printing process. The printing temperature of ether ketone cortical bone is very high, and the high-porosity structure of the inner cortical bone is easily affected by the high temperature of the outer layer and cannot be formed

Method used

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  • A kind of bone repair material constructed by 3D printing and its preparation method
  • A kind of bone repair material constructed by 3D printing and its preparation method
  • A kind of bone repair material constructed by 3D printing and its preparation method

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[0036] The present invention will be further described below in conjunction with more specific embodiments, but it should be pointed out that the 3D printed bone repair material and preparation method of the present invention are not limited to this specific form or procedure. It is obvious to those skilled in the art that the following descriptions can be directly applied to other components or preparation methods of similar composite materials not specified herein even without any adjustment or modification.

[0037] Such as Figure 4 , 5As shown, the bone repair material constructed by 3D printing of the present invention is prepared by 3D printing using specific materials according to the shape and structure requirements of human bones, wherein the bone repair material constructed by 3D printing includes an inner core structure, The outer layer structure 3 and the antibacterial spray layer 4; wherein, the inner core structure is further divided into an inner layer part 1 ...

Embodiment 1

[0051] (1) Boil the purchased beef bones in distilled water for 4 hours, remove most of the fat in the bones and remove the meat on the surface and the bone marrow inside, clean them with 30% hydrogen peroxide and 75% hydrogen peroxide respectively soaked in ethanol for 24 hours, dried in an oven at 60°C for 12 hours, the bone was broken into small pieces, then put into a ceramic crucible, and sintered in a vacuum muffle furnace at 800°C for 6 hours; The bones were placed in a high-speed pulverizer, the speed of which was maintained at 1000 rpm, and the grinding time was 4 hours to obtain self-made hydroxyapatite passing through a 800-mesh sieve;

[0052] (2) Mix the hydroxyapatite prepared above with polylactic acid, toughening agent, etc. according to the mass percentage composition of hydroxyapatite 5%, polylactic acid 80%, and toughening agent 15%, and then pass through the twin-screw The extruder realizes the process of mixing and pelletizing. Here, when the twin-screw ex...

Embodiment 2

[0057] (1) Boil the purchased pig bones in distilled water for 4 hours, remove most of the fat in the bones and remove the meat on the surface and the bone marrow inside, clean them with 30% hydrogen peroxide and 75% hydrogen peroxide respectively soaked in ethanol for 24 hours, dried in an oven at 60°C for 12 hours, then put the bones into small pieces, put them into a ceramic crucible, and sintered them in a vacuum muffle furnace at 800°C for 10 hours; The bones were placed in a high-speed pulverizer, the speed of which was maintained at 1500 rpm, and the grinding time was 3 hours to obtain self-made hydroxyapatite passing through a 800-mesh sieve;

[0058] (2) Mix the hydroxyapatite prepared above with polylactic acid, toughening agent, etc. according to the mass percentage composition of hydroxyapatite 10%, polylactic acid 70%, and toughening agent 20%, and then pass through the twin-screw The extruder realizes the process of mixing and pelletizing. Here, when the twin-scr...

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Abstract

The invention discloses a bone repair material constructed by 3D printing, a preparation method and application thereof. The bone repair material is composed of an inner core structure including an inner layer part and a peripheral part, an outer layer structure and an antibacterial spray layer. The 3D printed bone repair material of the present invention combines degradable materials with the ability to induce bone growth with engineering plastics with excellent mechanical properties by optimizing the structure, ensuring the strength of the bone repair material. The outermost layer is sprayed with The self-made hydroxyapatite and silver mixed powder of trace elements can promote bone healing and endow the material with certain antibacterial properties; in addition, the molding of the bone repair material of the present invention is realized by double-nozzle 3D printing, which omits the traditional The complicated process of processing technology improves the precision and realizes individual shaping, which is more in line with clinical needs.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, and in particular relates to a bone repair material constructed by 3D printing and a preparation method thereof. Background technique [0002] Bone grafting is one of the most commonly used surgical procedures in orthopedic surgery. Worldwide, more than 2 million bone grafts are performed each year, making it the second most common form of tissue transplant after blood transfusions. Among all clinically available bone grafts, autologous bone is considered the gold standard due to its combination of bone regenerative, osteoinductive, and osteogenic properties. But there are concerns about limited supply and donor site complications. Bone allografts are osteoconductive, have a wider origin but are less healing than those using autografts, and have the potential to transmit disease and other infectious agents. For this reason, research on artificial bone has attracted a lot of atte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/30A61L27/32A61L27/50A61L27/54A61L27/58B33Y70/10B33Y80/00
CPCA61L27/18A61L27/12A61L27/32A61L27/306A61L27/58A61L27/50A61L27/54B33Y70/00B33Y80/00A61L2430/02A61L2300/104A61L2300/606C08L61/16C08L67/04
Inventor 郑文旭覃柳琪苏其晟周武艺董先明谷文亮聂健良
Owner GUANGZHOU FEISHENG HIGH POLYMER MATERIAL CO LTD
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