Radioactive iodine marked protein binding ligand and application thereof

Abstract

The invention discloses a radioactive iodine marked protein binding ligand and application thereof. A structural formula of the radioactive iodine marked protein binding ligand is shown in a followingimage, wherein the I is radioactive iodine nuclide, the R is OH or derived from PEG, folic acid, RGD, octreotide, epidermal growth factor, protein, nucleic acid or polysaccharide. The radioactive iodine marked protein binding ligand disclosed by the invention has the advantages of simple marking method, low cost and good stability. Animal live test results show that the albumin binding ligand hashigher uptake and longer-time retention in blood and further has a higher target / non-target specific value. When the radioactive iodine marked protein binding ligand is modified to a target group orother functional groups, pharmacokinetic characters of compound can be obviously improved, a blood half-life period of the compound is prolonged, and the compound is suitable for being utilized as a blood pool, lymph and tumor diagnosing and treating reagent.

Description

technical field [0001] The invention belongs to the technical field of diagnostic reagents, and in particular relates to a radioactive iodine-labeled protein-binding ligand and an application thereof. Background technique [0002] Molecular imaging is known as medical imaging in the 21st century, because it can provide a strong guarantee for early detection, early diagnosis and early treatment of diseases. On the one hand, the development of imaging equipment has promoted the realization of early diagnosis and treatment of diseases; on the other hand, the development of non-invasive probes with good targeting, strong specificity and high sensitivity has become a key element of molecular imaging. Only by obtaining probes with good performance can we better diagnose and treat diseases and evaluate the prognosis. [0003] In recent years, cardiovascular system diseases and malignant tumors have seriously affected human health, and they have ranked the top two in the world's po...

AI Technical Summary

Problems solved by technology

Most of the drugs for the diagnosis and treatment of cardiovascular diseases have the following problems: such as short blood half-life, fast renal clearance rate, easy to be excreted from the body, making it necessary to use high doses or frequent administration, etc., which will inevitably produces a series of toxic and side effects, thus limiting its use

Although it is a relatively mature method to directly label albumin with radionuclides in vitro, it is a human extract, which is expensive and may cause immune rejection when injected into the body, and the protein is easily contaminated and denatured. Limit its application on

It can be seen that the existing relatively successful serum albumin labeling methods still have disadvantages such as complicated preparation methods, high prices, easy virus infection, and easily affected imaging effects by other factors. Radioactive markers with low cost and good effect that can effectively bind to albumin will have broad application prospects

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