A preparation method for grafting cationic antibacterial coating on the surface of aromatic polymer material

Abstract

The invention belongs to the field of organic polymer materials, and in particular relates to a preparation method for grafting a cationic antibacterial coating on the surface of an aromatic polymer material. The invention provides a new method of introducing a halomethyl group on the surface of an aromatic polymer through a phase transfer catalysis method, and then grafting a cationic macromolecule bactericidal coating on the surface. The outstanding advantage of this method is that it can directly introduce halomethyl groups on the surface of aromatic polymer products, and then carry out antibacterial functionalization. The method avoids the pollution problem caused by the introduction of an active free radical initiator in the modification of the polymer body in the organic solvent system by the traditional method. The modification reaction of the method does not use an organic solvent, and only occurs on the surface of the polymer, without affecting the inner layer of the polymer product. Therefore, this feature is of great significance to the preparation of medical sterilization functional materials, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of organic polymer materials, and in particular relates to a preparation method for grafting a cationic antibacterial coating on the surface of an aromatic polymer material. Background technique [0002] Aromatic polymer materials are a kind of high-performance polymers with heat resistance and stable mechanical properties. As medical materials, they can replace some metal materials, so they are widely used in the field of medical devices and medical materials. For example, aromatic polysulfones can also be used as hemodialysis membrane materials. According to statistics, the infection caused by the pollution of medical devices accounts for more than 30% of the total surgical infection rate every year. Therefore, the surface of medical devices has antibacterial function, especially for implantable polymer materials. Functional polymer materials are a prerequisite for improving their performance. [0003] The traditi...

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Problems solved by technology

but use figure 1 The method of preparing the cast membrane of chloromethylated polymer leads to a significant decrease in protein retention rate, indicating that the membrane pore size of the new polymer becomes larger, that is, this functional modification method affects the performance of the material

For some polymer materials that can only be dissolved in phenolic solvents, because phenolic compounds are more likely to undergo halomethylation, so figure 1 The method described is not suitable for such aromatic polymer materials, such as some polyimide varieties

Therefore, the shortcomings of the traditional method of introducing halomethyl groups are: 1) the catalyst SnCl used 4 Toxic and easy to hydrolyze, SnO generated by hydrolysis in the post-treatment stage 2 It is difficult to remove from the polymer, the catalyst cannot be recycled and reused, and it is easy to cause environmental pollution; 2) The reaction is sensitive to water, and a large excess of catalyst and halogenated reagent is required to avoid reaction failure due to hydrolysis failure of the catalyst and halogenated reagent; 3) Using Volatile and toxic organic solvents, difficult to deal with after recycling

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