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Omeprazole soluble powder for livestock and preparation process of omeprazole soluble powder

A technology of soluble powder and omeprazole, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, powder delivery, etc., can solve problems such as poor water solubility, improve stability, and provide good symptomatic treatment Effect, quality controllable effect

Inactive Publication Date: 2017-11-28
洛阳市兽药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is in order to overcome the deficiencies in the prior art, provide a kind of omeprazole soluble powder for livestock and poultry and preparation technology thereof, have developed the new dosage form of omeprazole that is suitable for group medication, can make up for omeprazole The disadvantage of poor water solubility and inability to mix with drinking medicines is to improve its water solubility by adding cosolvents and stabilizers to improve its stability. It can be administered through drinking water, easy to use, and has good symptomatic treatment for pig gastritis and poultry gland gastritis. It has good water solubility, stability, low production and application costs, and convenient packaging and transportation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In the first step, omeprazole and sodium carbonate are stirred and mixed uniformly in a step-by-step manner to obtain a mixture A, which is set aside; the mixture A is added to polyethylene glycol 6000 and stirred evenly to obtain a mixture B, which is set aside;

[0023] In the second step, sodium sulfite, EDTA-2Na and sodium saccharin are stirred and mixed evenly to obtain mixture C, which is set aside;

[0024] In the third step, the prepared mixture B and mixture C are stirred and mixed evenly to obtain mixture D, which is set aside;

[0025] In the fourth step, add the prepared mixture D into lactose, stir and mix evenly at room temperature to obtain mixture E, and set aside;

[0026] In the fifth step, the prepared mixture E is directly sieved or crushed and then sieved, and the sieve is 60-80 mesh, and packed in 100g packaging bags, and the finished product is obtained after sealing.

Embodiment 2

[0028] In the first step, omeprazole and potassium carbonate are stirred and mixed evenly in a step-by-step manner to obtain a mixture A, which is set aside; the mixture A is added to PVPK30 and stirred evenly to obtain a mixture B, which is set aside;

[0029] In the second step, sodium tripolyphosphate, sodium sulfite and mannitol are stirred and mixed evenly to obtain mixture C, which is set aside;

[0030] In the third step, the prepared mixture B and mixture C are stirred and mixed evenly to obtain mixture D, which is set aside;

[0031] In the fourth step, the prepared mixture D is added to glucose, stirred and mixed evenly at room temperature to obtain mixture E, which is set aside;

[0032] In the fifth step, the prepared mixture E is directly sieved or crushed and then sieved, and the sieve is 60-80 mesh, and packed in 100g packaging bags, and the finished product is obtained after sealing.

Embodiment 3

[0034] In the first step, first stir and mix omeprazole sodium and potassium carbonate in a step-by-step manner to obtain mixture A, which is set aside; add mixture A to polyethylene glycol 6000 and stir and mix evenly to obtain mixture B, which is set aside ;

[0035] In the second step, sodium tripolyphosphate, sodium sulfite and sodium saccharin are stirred and mixed evenly to obtain mixture C, which is set aside;

[0036] In the third step, the prepared mixture B and mixture C are stirred and mixed evenly to obtain mixture D, which is set aside;

[0037] In the fourth step, the prepared mixture D is added to glucose, stirred and mixed evenly at room temperature to obtain mixture E, which is set aside;

[0038] In the fifth step, the prepared mixture E is directly sieved or crushed and then sieved, and the sieve is 60-80 mesh, and packed in 500g packaging bags, and the finished product is obtained after sealing.

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PUM

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Abstract

The invention discloses omeprazole soluble powder for livestock and a preparation process of the omeprazole soluble powder. The omeprazole soluble powder for livestock contains the following components: 0.5-6g of omeprazole sodium or omeprazole, 1.25-15g of an alkali cosolvent, 1-6g of a macromolecule solubilizer, 1-7.5g of a stabilizer, 0.1-2g of a sweetening agent and 63.5-96.15g of auxiliary materials, wherein the total weight of the mixed components is 100g. Defects that omeprazole is poor in water solubility and cannot be taken in a mixed drinking manner are overcome, due to adding of the cosolvent, the water solubility of the omeprazole is improved; due to adoption of the stabilizer, the stability of the omeprazole is improved; water drinking administration is achieved, and thus the omeprazole soluble powder is convenient to use, good in symptomatic treatment on pig gastritis and proventriculitis, good and stable in water solubility, low in production and application cost and convenient in packaging and transportation.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a omeprazole soluble powder for livestock and poultry and a preparation process thereof. Background technique [0002] Omeprazole (omeprazole) is a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease (GERD) and other diseases. The activity of -ATPase prevents the H+ in the parietal cells from being transported into the gastric cavity, thereby effectively inhibiting the secretion of gastric acid and greatly reducing the amount of gastric acid in the gastric juice. It has a strong and long-lasting inhibitory effect on gastric acid secretion caused by various reasons. It has been recorded in the United States Pharmacopoeia, European Pharmacopoeia, Chinese Pharmacopoeia and other multinational pharmacopoeias, and is widely used in domestic and foreign medicine for gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis an...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/4439A61K47/02A61K47/26A61K47/12A61K47/32A61K47/10A61K47/40A61K47/18A61K47/22A61P1/04
CPCA61K9/143A61K9/145A61K9/146A61K31/4439
Inventor 胡涵贺晓珺魏巍吉朝松郭俊俊
Owner 洛阳市兽药厂
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