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Site-specific osmotic-pump controlled-release capsule shell and preparation method thereof

A technology of osmotic pump controlled release and capsule shell, which is applied in the field of medicine, can solve the problems that it is not suitable for the preparation of osmotic pump tablets, and achieve the effects of stable curative effect, slow drug release, and constant drug release

Inactive Publication Date: 2015-07-22
胡容峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs with large doses and too high or too low solubility are not suitable for preparation into osmotic pump tablets

Method used

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  • Site-specific osmotic-pump controlled-release capsule shell and preparation method thereof
  • Site-specific osmotic-pump controlled-release capsule shell and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Capsule Shell Composition:

[0026] 1.5 g of cellulose acetate; 5.0 g of cellulose acetate phthalate; 1.5 g of polyethylene glycol-200; 1.5 g of tributyl citrate; 0.5 g of titanium dioxide;

[0027] Preparation process: first dissolve cellulose acetate and phthalate cellulose acetate in acetone, add polyethylene glycol and tributyl citrate as plasticizers, put the weighed titanium dioxide into it, stir well, Let stand to remove air bubbles. Make a blank by dipping in glue, dry it, prepare a drug release hole with a diameter of 1.0mm on the capsule body by laser or mechanical drilling, seal the enteric-coated or colonic-coated capsule liquid and dry it, pull out the shell, cut, and arrange, that is Position the osmotic pump capsule housing.

Embodiment 2

[0029] Capsule Shell Composition:

[0030] 1.5 g of cellulose acetate; 5.0 g of hydroxypropyl methylcellulose acetate succinate (HPMCAS); 2.0 g of castor oil; 1.0 g of triethyl citrate;

[0031] Preparation process: first dissolve cellulose acetate and hydroxypropyl methylcellulose acetate succinate (HPMCAS) in acetone, add castor oil and triethyl citrate as plasticizers, the preparation process is the same as Example 1, Prepare a drug release hole with a diameter of 0.5mm on the capsule body and capsule cap by laser or mechanical drilling, seal with gelatin solution and dry, pull out the shell, cut, and arrange to obtain the positioning osmotic pump capsule shell.

Embodiment 3

[0033] Capsule Shell Composition:

[0034] Ethyl cellulose 2.5g; cellulose acetate phthalate 10g; polyethylene glycol-400 2.0g; dibutyl phthalate 1.5g; titanium dioxide 0.5g;

[0035] Preparation process: first dissolve ethyl cellulose and cellulose acetate phthalate in 95% ethanol, add polyethylene glycol-400 and dibutyl phthalate as plasticizers, add titanium dioxide and stir well, and prepare The process is the same as in Example 1. A drug release hole with a diameter of 1.0 mm is prepared on the capsule body by laser or mechanical drilling, and the capsule liquid is sealed and dried.

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Abstract

The invention relates to a site-specific osmotic-pump controlled-release capsule shell and a preparation method thereof. The capsule shell is simple to prepare, has a wide application scope and realizes the effect of site-specific controlled-release of drugs. The site-specific osmotic-pump controlled-release capsule shell is composed of a capsule cap and a capsule body and provided with a drug release hole; and the capsule shell is used for filling of chemical drugs, traditional Chinese medicines, biological drugs, etc., can control drug release rates and enables the drug release rates to be constant. The site-specific osmotic-pump controlled-release capsule shell can be prepared by using a conventional capsule shell preparation method; the drug release hole with a certain pore size is formed in the capsule shell in virtue of laser, a machine or other proper methods; and test results of filled drugs prove that the capsule shell provided by the invention has the characteristic of capacity of allowing drugs to be constantly released at in-vivo specific sites (e.g., a position where small intestine or colon is located).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a capsule shell for controlled release of a positioning osmotic pump and a preparation method thereof. More specifically, it is a positioning osmotic pump controlled-release capsule shell made of enteric-coated or colonic-coated materials and its preparation method. The capsules of this invention can be used for filling chemical drugs, traditional Chinese medicines, biological products, etc., and can control the drug release rate. , the drug release rate is constant. Background technique [0002] The research and development of sustained / controlled release preparations has become a hot spot in the research and development of medicine in the world today. Sustained / controlled release preparations can keep the human body at the effective blood concentration for a longer period of time, thereby avoiding the "peak and valley" phenomenon that occurs when common preparations are frequ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61J3/07A61K47/32A61K47/34A61K47/36A61K47/38
Inventor 陆文捷胡容峰
Owner 胡容峰
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