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Preparation method of porous tantalum applicable to replacing human dentale tissue

A porous tantalum and dental bone technology is applied in the field of preparation of medical metal implant materials, which can solve the problems affecting the processing and mechanical properties of porous tantalum materials such as ductility, compressive strength, and insufficient bending strength, and improve biocompatibility. and biological safety, good pore size uniformity of finished products, and the effect of improving mechanical properties

Active Publication Date: 2012-11-28
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, porous tantalum, which is used as a medical implant material for compact bone tissue such as dental bone, has obvious deficiencies in mechanical properties such as ductility, compressive strength, and bending strength, and will affect subsequent research on porous tantalum. Processing of the material itself, such as cutting of molded parts, etc.

Method used

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  • Preparation method of porous tantalum applicable to replacing human dentale tissue
  • Preparation method of porous tantalum applicable to replacing human dentale tissue
  • Preparation method of porous tantalum applicable to replacing human dentale tissue

Examples

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Embodiment 1

[0021] Embodiment 1: Take paraffin wax, tantalum powder and ethyl cellulose with an average particle size less than 43 microns and an oxygen content of less than 0.1% and mix them uniformly to form a mixed powder, wherein paraffin wax accounts for 8%, ethyl cellulose accounts for 27%, tantalum powder accounts for 65%, all in volume percentage. Granulation: The mixed powder is granulated into round particles with a particle diameter of 10-13 μm at a working temperature of 510-520° C. and a working pressure of 12-13 MPa. Injection molding: the temperature for injecting the round particles into the mold is 465-490° C. and the pressure is 83-85 MPa. Demolding time: 6~7S. Degreasing treatment: vacuum degree 10 -4 Pa, rise from room temperature to 400°C at a rate of 1-3°C / min, hold for 60-120 minutes, rise from 400°C to 600-800°C at a rate of 1.5-2.5°C / min, and hold for 180-240 minutes. Vacuum sintering: vacuum degree is 10 -4 Pa~10 -3 Pa, heat up to 1800°C at 13°C / min, hold fo...

Embodiment 2

[0023] Embodiment 2: Weigh polyvinyl alcohol, tantalum powder with an average particle size less than 43 microns and an oxygen content of less than 0.1%, and sodium bicarbonate and mix them uniformly to form a mixed powder, wherein polyvinyl alcohol accounts for 6%, sodium bicarbonate accounts for 29%, tantalum Powder accounted for 65%, all in volume percentage. Granulation: The mixed powder was granulated into round particles with a particle diameter of 20 μm at a working temperature of 450° C. and a working pressure of 15 MPa. Injection molding: the temperature of injecting the round particles into the mold is 540° C. and the pressure is 90 MPa. Demolding time: 9S. Degreasing treatment: vacuum degree 10 -4 Pa, raise the temperature from room temperature to 400°C at a heating rate of 1°C / min, and hold for 60 minutes; then raise the temperature from 400°C to 800°C at a heating rate of 2.5°C / min, and hold for 180 minutes. Vacuum sintering: the vacuum degree is 10-4Pa, heat u...

Embodiment 3

[0025] Embodiment 3: take by weighing zinc stearate, average particle diameter less than 43 micron oxygen content less than 0.1% tantalum powder and methyl cellulose and mix uniformly into mixed powder, wherein zinc stearate accounts for 10%, methyl cellulose accounts for 10%. 23%, tantalum powder accounted for 67%, both by volume percentage. Granulation: The mixed powder was granulated into circular particles with a particle diameter of 10 μm at a working temperature of 650° C. and a working pressure of 12 MPa. Injection molding: the temperature of injecting the round particles into the mold is 380° C. and the pressure is 72 MPa. Demolding time: 6S. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 3°C / min and hold for 120 minutes; then at a heating rate of 1.5°C / min from 400°C to 750°C for 240 minutes. Vacuum sintering: vacuum degree is 10 -3 Pa, heat up to 1800°C at 15°C / min, hold for 200min, cool with the furnace to 200-3...

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Abstract

The invention provides a preparation method of porous tantalum applicable to replacing human dentale tissue. The preparation method comprises the following steps of: mixing tantalum powder, pore-forming agent and forming agent to form into mixed powder, pelleting, injecting into a mould to be formed, demoulding, degreasing, sintering and carrying out thermal treatment, wherein the pore-forming agent is one kind or several kinds of sodium bicarbonate, urea, sodium chloride, methylcellulose and ethocel; the forming agent is one kind or several kinds of poval, stearic acid, zinc stearate, paraffins and synthetic rubber; the degreasing process comprises the following steps of: gradually heating up to 400-800 DEG C at the speed of the 0.5-3DEG C / min, forming the protective atmosphere by charging argon, and keeping the temperature for 60-240min; and the sintering step comprises the following steps of: heating up to 1500-1800 DEG C at the speed of 10-20 DEG C / min under the vacuum degree of 10<-4>-10<-3>Pa, keeping the temperature for 120-240min, cooling to 200-300DEG C along with a furnace, heating up to 1500-1800 DEG C at the speed of 10-20 DEG C / min, keeping the temperature for 180-240min, heating up to 2000-2200 DEG C at the speed of 5-10 DEG C / min, and keeping the temperature for 120-360min. The prepared porous tantalum is very applicable to the medical implant material capable of replacing the human dentale tissue.

Description

technical field [0001] The invention relates to a preparation method of a medical metal implant material, in particular to a preparation method of a medical porous metal implant material suitable for replacing human dental bone tissue. Background technique [0002] Porous medical metal implant materials have important and special uses in the treatment of bone tissue trauma, femoral tissue necrosis, and replacement of dense bone tissue such as dental bone. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and evenly distributed, or it should be consistent with the growth of human bone tissue as needed. , and reduce the weight of the material itself, so that it is suitable for human implantation. [0003] As for the refractory metal tantalum, due to its exce...

Claims

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Application Information

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IPC IPC(8): C22C1/08C22C27/02A61L27/04A61L27/56
CPCA61L2430/02B22F2998/10A61L2430/12A61L27/047A61L27/04A61L27/56B22F3/1121C22C1/08C22C27/02B22F1/10B22F3/225B22F3/10
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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