Multilayer copolymerized compound membrane soft bagged inosine in sodium chloride injection composition and its manufacturing method

A technology of inosine sodium chloride, multi-layer co-extrusion, applied in the field of medicine, can solve the problems of easy side effects, PVC soft bags are not easy to be degraded and recycled, storage area is large, etc., to achieve stable infusion concentration, excellent thermal welding Sealing effect, low water vapor permeability effect

Inactive Publication Date: 2008-08-13
武汉同源药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the glass bottle or hard plastic bottle injection must be introduced into the air, and there are many patients in the hospital, there are many pathogenic microorganisms, and the air pollution is serious, the introduction of air during the infusion is likely to cause infusion reactions or cross-infection to the patient. In addition, the glass bottle or Hard plastic bottles have a certain shape and large volume, are easily broken during transportation, and occupy a large area for storage, etc.
There are also some problems in plastic PVC soft bags. For example, there are dozens of formula components, some of which are even small molecular additives, and the amount of plasticizer is as high as about 50%. Trace components will be partially separated and enter the liquid medicine. When the liquid medicine is injected into the human body, side effects are likely to occur, and even cause serious harm to the human body; PVC soft bags have poor heat resistance and are inconvenient to disinfect. The storage period is short, it is difficult to meet the use requirements
In addition, PVC soft bags are not easy to degrade and recycle, which is easy to cause environmental pollution

Method used

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  • Multilayer copolymerized compound membrane soft bagged inosine in sodium chloride injection composition and its manufacturing method
  • Multilayer copolymerized compound membrane soft bagged inosine in sodium chloride injection composition and its manufacturing method

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Embodiment 1: According to the proportion that every 100ml inosine sodium chloride injection composition contains inosine 0.6g, sodium chloride 0.9g, weigh inosine, add the water for injection of about 80% of the total amount, after stirring evenly, add Sodium chloride, stir to dissolve, add water for injection to nearly full amount, stir well, add 0.03wt% activated carbon for needles, stir evenly, filter and remove activated carbon after standing, add water for injection to full amount, adjust pH value to 7.5. After the semi-finished product passes the inspection, it is filtered with 0.45 μm and 0.22 μm microporous membranes in turn to obtain the composition of inosine sodium chloride injection; in the 100-class clean area, it is polymerized by modified ethylene propylene sequentially from the inside to the outside. layer, polyethylene layer, polyethylene layer, ethylene methacrylate polymer layer and polyester copolymer layer (purchased from Sealed Air Packaging (Shang...

Embodiment 2

[0016] Embodiment 2: According to the ratio that every 100ml inosine sodium chloride injection composition contains inosine 0.6g, sodium chloride 0.9g, D-glucono-δ-lactone 0.1g, weigh inosine and D-glucose Acid-δ-lactone and mix to obtain a mixture, then add about 80% of the total amount of water for injection, heat to 52°C, stir until the mixture of inosine and D-glucono-δ-lactone is completely dissolved, cool down to room temperature, and then add Sodium chloride, stir to dissolve, add water for injection to 90% of the total amount, stir well, add 0.03wt% activated carbon for needles, stir evenly, filter and remove the activated carbon after standing, add water for injection to the full amount, and use D-gluconic acid- δ-lactone adjusts the pH value to 6.5, and the inosine sodium chloride injection composition is obtained by filtration through a microporous membrane; in a class 100 clean area, the multilayer co-extruded composite film and plastic infusion as described in Exam...

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Abstract

The invention relates to a multi-layer co-extrusion compound film inosine sodium chloride injecta composite packaged by soft bag: every 100 ml inosine sodium chloride injecta composite contains 0.6g plusing or subtracting 0.05g inosine, 0.9 plusing or subtracting 0.05g sodium chloride, 0.1g plusing or subtracting 0.02g D-gluconic acid-delta-lactone; in a hundred-level cleaning area, after adopting a multi-layer co-extrusion compound film and a plastic transfusion vessel joint to heat, the inosine solium chloride injecta composite is filled and sealed with a plastic transfusion vessel pull-tab type seal cover, to obtain multi-layer co-extrusion compound film inosine sodium chloride injecta composite packaged by soft bag. The preparation method is: inosine or the mixture of inosine and D-gluconic acid-delta-lactone is added by water for injection, adding sodium chloride after mixing and being filtered by microporous filtering film to obtain inosine sodium chloride injecta composite; after adopting a multi-layer co-extrusion compound film and a plastic transfusion vessel joint to heat, the inosine solium chloride injecta composite is filled and sealed with a plastic transfusion vessel pull-tab type seal cover, then through sterilization to obtain the composite of the invention.

Description

technical field [0001] The invention relates to a multi-layer co-extruded composite film soft bag inosine sodium chloride injection composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Inosine is a purine nucleoside compound, white crystalline powder. The melting point is 218°C (decomposition). Slightly soluble in water, insoluble in chloroform or ethanol. Odorless, slightly bitter taste. [0003] Inosine is a normal component of the human body. It participates in nucleic acid metabolism, protein synthesis and energy metabolism in the body. It can increase the activity of coenzyme A and pyruvate oxidase, so that cells can perform normal metabolism under hypoxic conditions and contribute to the recovery of damaged liver cells. Recovery, can stimulate the body to produce antibodies and promote intestinal absorption of iron; used for adjuvant treatment of leukopenia and thrombocytopenia, heart failure, angi...

Claims

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Application Information

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IPC IPC(8): A61J1/10A61J3/00A61K9/08A61K31/708A61P9/00A61P29/00
Inventor 徐敏华熊骏宇陈雪红
Owner 武汉同源药业有限公司
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