Patents

Literature

Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.

51results about How to "Use in synthesis" patented technology

Filter

Efficacy Topic

Property

Owner

Technical Advancement

Application Domain

Technology Topic

Technology Field Word

Patent Country/Region

Patent Type

Patent Status

Application Year

Inventor

Varied morphology carbon nanotubes and method for their manufacture

InactiveUS7157068B2Increased yieldPromote catalyst activityMaterial nanotechnologyCarbon compoundsCarbon nanotubeMaterials science

The present invention describes the preparation of carbon nanotubes of varied morphology, catalyst materials for their synthesis. The present invention also describes reactor apparatus and methods of optimizing and controlling process parameters for the manufacture carbon nanotubes with pre-determined morphologies in relatively high purity and in high yields. In particular, the present invention provides methods for the preparation of non-aligned carbon nanotubes with controllable morphologies, catalyst materials and methods for their manufacture.

Varied morphology carbon nanotubes and method for their manufacture

View all

Owner:TRUSTEES OF BOSTON COLLEGE THE

Pyrrolobenzodiazepines and conjugates thereof

ActiveUS20140120118A1Reduction in lipophilicityAid solubilityAntinoxious agentsImmunoglobulinsPyrrolobenzodiazepineOrganic chemistry

A compound which is selected from A:

and C:

and salts and solvates thereof, as well as conjugates thereof with cell binding agent.

View all

Owner:MEDIMMUNE LTD

Malonic acid monomethyl derivatives and production process thereof

InactiveUS7109369B2Easy to makeProduct can be usedOrganic compound preparationCarboxylic acid esters preparationHydrogen atomMalonic acid

A novel monomethyl malonate derivative is represented by following Formula (I):wherein X is a halogen atom; and Me is methyl group. This compound can be prepared by the steps of (A) reacting a benzyl halide derivative represented by following Formula (II):wherein X and Y may be the same as or different from each other and are each a halogen atom, with dimethyl malonate in the presence of a base to yield a dimethyl malonate derivative represented by following Formula (III):wherein X and Me have the same meanings as defined above; and (B) hydrolyzing the dimethyl malonate derivative of Formula (III). The compound is useful in the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring.

Malonic acid monomethyl derivatives and production process thereof

View all

Owner:DAICEL CHEM IND LTD

Varied morphology carbon nanotubes

InactiveUS20080118426A1Increase productionHigh catalytic activityMaterial nanotechnologyCarbon compoundsCarbon nanotubeMaterials science

View all

Owner:TRUSTEES OF BOSTON COLLEGE THE

Catalysts for epoxide carbonylation

InactiveUS20170080409A1Use in synthesisIncrease the rate of chemical reactionsOrganic-compounds/hydrides/coordination-complexes catalystsGroup 3/13 element organic compoundsPtru catalystEthylene oxide

The present invention encompasses catalysts for the carbonylation of heterocycles such as ethylene oxide, as well as methods for their use. The catalysts feature Lewis acidic metal complexes having one or more tethered metal-coordinating groups in combination with at least one metal carbonyl species. In preferred embodiments, the inventive catalysts have improved stability when subjected to product separation conditions in continuous ethylene oxide carbonylation processes.

View all

Owner:NOVOMER INC

Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them

InactiveUS20050271690A1Highly toxicUse in synthesisAntibacterial agentsBacteriaGangliosideOpen reading frame

The present invention is directed to nucleic acids encoding glycosyltransferases, the proteins encoded thereby, and to methods for synthesizing oligosaccharides using the glycosyltransfereses of the invention. In particular, the present application is directed to identification a glycosyltransferase locus of Neisseria gonorrhoeae containing five open reading frames for five different glycosyltransferases. The functionally active glycosyltransferases of the invention are characterized by catalyzing reactions such as adding Gal β1→4 to GlcNAc or Glc; adding GalNAc or GlcNAc β1→3 to Gal; and adding Gal α1→4 to Gal. The glycosyltransferases of the invention are particularly suited to the synthesis of the oligosaccharides Galβ1→4GlcNAcβ1→3Galβ1→4Glc (a mimic of lacto-N-neotetraose), GalNAcβ1→3Galβ1→4GlcNAcβ1→3Galβ1→4Glcβ1→4 (a mimic a ganglioside), and Galα1→4Galβ1→4Glcβ1→4Hep→R (a mimic of the saccharide portion of globo-glycolipids).

Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them

View all

Owner:GOTSCHLICH EMIL

Organosilane compound and organosilica obtained therefrom

InactiveUS20080227939A1Use in synthesisEasy to synthesizeSilicon organic compoundsGroup 8/9/10/18 element organic compoundsHydrogen atomSilicon dioxide

Provided is an organosilane compound expressed by any one of the following general formulae (1) to (7):

(wherein: Ar represents a phenylene group or the like; R¹represents a hydrogen atom or the like; R²to R⁸each represent a methyl group or the like; n represents an integer in a range from 0 to 2; m represents an integer of 1 or 2; L represents a single bond or the like; X represents a hydrogen atom or the like; and Y represents a hydrogen atom or the like).

Organosilane compound and organosilica obtained therefrom

View all

Owner:TOYOTA CENT RES & DEV LAB INC +1

Methods and materials for the production of organic products in cells of Candida species

InactiveUS7141410B2Good conditionUse in synthesisSugar derivativesMicroorganismsHeterologousBiotechnology

The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Candida cells, methods for making the Candida cells, and their use in production of organic products, particularly lactic acid.

Methods and materials for the production of organic products in cells of <i>Candida </i>species

View all

Owner:CARGILL INC

Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases

InactiveUS20060217551A1Use in synthesisAntibacterial agentsOrganic active ingredientsCompound (substance)Nucleoside phosphorylase

The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and / or nucleoside hydrolases (NH).The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and / or nucleoside hydrolases (NH).

Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases

View all

Owner:IND RES LTD

Process for preparing pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases

InactiveUS7655795B2Use in synthesisAntibacterial agentsBiocideNucleoside phosphorylasePyrrole

The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and / or nucleoside hydrolases (NH). The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and / or nucleoside hydrolases (NH).

Process for preparing pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases

View all

Owner:IND RES LTD

Silicon compound

ActiveUS20050250925A1Good polymerizationExcellent living radical polymerization accelerating functionSilicon organic compoundsArylPolymer science

The present invention provides a novel silicon compound represented by Formula (1) having a living radical polymerization initiating ability for addition-polymerizable monomers and a polymer obtained using the same. The above polymer can provide an organic-inorganic composite material having a distinct structure. wherein R1 is hydrogen, alkyl, aryl or arylalkyl; R2 and R3 are alkyl, phenyl or cyclohexyl; and A is a group having an ability to initiate polymerization of a monomer.

View all

Owner:JNC CORP

Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases

InactiveUS20100094003A1Use in synthesisAntibacterial agentsOrganic active ingredientsPhosphorylationMethyl palmoxirate

The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and / or nucleoside hydrolases (NH). The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and / or nucleoside hydrolases (NH).

View all

Owner:EVANS GARY BRIAN +1

Linker based solid support for peptide and small molecule organic synthesis

InactiveUS6492460B2High yieldHigh purityMacromolecular librariesPeptide preparation methodsOrganic synthesisPolystyrene

The present invention relates to a novel linker based solid support, methods for generating the linker moiety on the solid support, and methods of using the supports to synthesize peptides and small molecule combinatorial library and the new solid support of this invention also comprises a functionalized linker covalently attached to the solid supports such as polystyrene.

Linker based solid support for peptide and small molecule organic synthesis

View all

Owner:COUNCIL OF SCI & IND RES

Adsorptivity imparting agent containing porous silica

InactiveUS8034740B2Improve adsorption capacityPreventing hands, ovens, clothes and the like from being soiledCosmetic preparationsDough treatmentFiltrationSilicon dioxide

A moisture- or protein-adsorbability imparting agent, comprising a porous silica having a hexagonal pore structure, an average pore size of from 0.8 to 20 nm, an average particle size of 50 nm to 100 μm, a specific surface area of from 400 to 2000 m2 / g, and a pore volume of from 0.1 to 3.0 cm3 / g; a material having an adsorbability of moisture or a protein, comprising the moisture- or protein-adsorbability imparting agent; and use of the moisture- or protein-adsorbability imparting agent for imparting absorbability of moisture or a protein to a material selected from the group consisting of food wrapping materials; filtration aid agents; sanitary articles; compositions containing a synthetic resin; moisture-controlled material; covering materials for wounds; insulation substrates; coating materials for semiconductor devices; cosmetics; inkjet recording media; and compositions containing synthetic fibers.

Adsorptivity imparting agent containing porous silica

View all

Owner:TAIYO KAGAKU CO LTD +1

CHIRAL TETRAAMINOPHOSPHONIUM SALTS, CATALYST FOR ASYMMETRIC SYNTHESIS AND METHOD FOR PRODUCING CHIRAL beta-NITROALCOHOL

ActiveUS20090131716A1High activityHigh steric controlOrganic compound preparationGroup 5/15 element organic compoundsHydrogen atomEnantioselective synthesis

A chiral tetraaminophosphonium salt represented by formula (1) and a method for producing chiral β-nitroalcohol comprising reacting an aldehyde or a ketone and a nitroalkane in the presence of the chiral tetraaminophosphonium salt represented by formula (1) and a base, or in the presence of a conjugated base of the chiral tetraaminophosphonium salt represented by formula (1):

wherein R¹to R⁴are independently a hydrogen atom or a monovalent hydrocarbon group; and, R¹and R²are different groups or R³and R⁴are different groups.

CHIRAL TETRAAMINOPHOSPHONIUM SALTS, CATALYST FOR ASYMMETRIC SYNTHESIS AND METHOD FOR PRODUCING CHIRAL beta-NITROALCOHOL

View all

Owner:MITSUI CHEM INC +1

Radiolabeled Glycine Trasporter Inhibitors

ActiveUS20090269278A1Use in synthesisBiocideIsotope introduction to heterocyclic compoundsGlycineCombinatorial chemistry

The present invention is directed to radiolabeled glycine transporter inhibitors which are useful for the labeling and diagnostic imaging of glycine transporters in mammals.

Radiolabeled Glycine Trasporter Inhibitors

View all

Owner:MERCK SHARP & DOHME LLC

Multifunctional crosslinking agent, crosslinked polymer, and method of making same

ActiveUS10294255B1Use in synthesisGroup 4/14 element organic compoundsGroup 5/15 element organic compoundsArylImide

A multifunctional crosslinking agent, a crosslinked polymer, and a method of making the same are disclosed. The multifunctional crosslinking agent, which may be used to crosslink amine-terminated polyamides, polyimides, or poly(amide-imide)s, includes three or four anhydride functional groups. The multifunctional crosslinking agent may be defined by a general chemical formula (I): (Z—Ar—)_n—W, wherein W represents an anhydride functional group that is directly or indirectly bonded to Ar; Ar represents an aryl group that is directly bonded to W; and n is equal to 3 when W is P═O or N, or n is equal to 4 when W is Si or a carbon moiety.

Multifunctional crosslinking agent, crosslinked polymer, and method of making same

View all

Owner:THE UNITED STATES OF AMERICA AS REPRESETNED BY THE SEC OF THE AIR FORCE

Method of identifying nucleic acid

InactiveUS20060234228A1Easily detectEasily differenceSugar derivativesMicrobiological testing/measurementNucleotide sequencNucleic acid test

Test nucleic acids are identified by the steps of: synthesizing multiple nucleic acids that comprise nucleotide sequences complementary to different regions of a test nucleic acid; and comparing the dissociation curve of a mixture of the synthesized nucleic acids. The dissociation curve of a mixture of nucleic acids shows a waveform pattern that is unique to the test nucleic acid. Many types of nucleic acids can be efficiently identified using simple reactions. The multiple types of nucleic acids that are necessary for analysis can be easily synthesized by using a primer complex that anneals to multiple regions of the test nucleic acid.

View all

Owner:G&G SCI

Silicon compound

ActiveUS7256243B2Good polymerizationExcellent living radical polymerization accelerating functionSilicon organic compoundsArylHydrogen

The present invention provides a novel silicon compound represented by Formula (1) having a living radical polymerization initiating ability for addition-polymerizable monomers and a polymer obtained using the same. The above polymer can provide an organic-inorganic composite material having a distinct structure.wherein R1 is hydrogen, alkyl, aryl or arylalkyl; R2 and R3 are alkyl, phenyl or cyclohexyl; and A is a group having an ability to initiate polymerization of a monomer.

View all

Owner:JNC CORP

Method for producing pyrrolidine compound

InactiveUS20100010219A1Good achievabilityUse in synthesisOrganic chemistryMetabolism disorderEnantioselective synthesisMedicinal chemistry

Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost.A method of producing a compound represented by the following formula [8]:or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]:or a reactive derivative thereof, or a salt thereof, or a solvate thereof.

Method for producing pyrrolidine compound

View all

Owner:JAPAN TOBACCO INC

Α-1,3 fucosyltransferases and expression systems for making and expressing them

InactiveUS6962806B2Use in synthesisSugar derivativesBacteriaWilms' tumorAmino acid

A bacterial α1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing α1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.