The invention is suitable for a communication field, and provides an interference control method and device for a same frequency network of macro and micro base stations. The method comprises that: the micro base station scans wireless environment in which the micro base station is, to obtain a scanning result; the micro base station reports the scanning result to a superior network unit, so as that the superior network unit can determine the a residential area with strongest micro base station signal intensity based on the scanning result, and configures configuration parameters of the residential area to the micro base station; the micro base station respectively judges whether each service channel is carried out service loading by the micro base station; for the service channer of which service is not loaded by the micro base station, the micro base station obtains an upward interference estimator of UE to the micro base station on the service channel, and offsets the upward interference estimator in the upward signal on the received service channel. The method and the device provided by the invention, based on a network structure of same-frequency arranging the macro base station and one or more micro base station which are stacked in a covering range of the macro base station, reduces upward interference caused by UE, and raises network throughput.