A locking and separating system for a furniture drawer front panel comprises a fixing device arranged on a side plate. The front panel is connected with the fixing device through two connecting elements. Two sets of locking and separating mechanisms for locking and separating the connecting elements are arranged on the fixing device. Each locking and separating mechanism is provided with a finger-shaped element and an unlocking element which is in transmission connection with the finger-shaped element, wherein the finger-shaped element and the corresponding connecting element are locked and separated through movement of the unlocking element. The two sets of locking and separating mechanisms are independently and vertically arranged and do not interfere with each other when the locking and separating mechanisms and the corresponding connecting elements are locked and separated in a matched mode. Unlocking components are arranged on the locking and separating mechanisms, and the unlocking components jointly act on the unlocking elements of the two sets of locking and separating mechanisms successively, so that the finger-shaped elements are disengaged from the connecting elements, and the front panel is separated from the side plate. According to the structural improvement, the locking and separating system has the advantages of being simple and reasonable in structure, reliable in performance, firm in connection, low in manufacturing cost, rapid and convenient to disassemble and assemble, high in flexibility and practicability, and the like.