The invention discloses a six-degree of freedom motion platform, which comprises an upper platform (1), a lower platform (2) and six electric push rods (3), wherein the electric push rods (3) are distributed between the upper platform (1) and the lower platform (2), and two ends of each electric push rod are hinged with the upper platform (1) and the lower platform (2) respectively in a one-to-one correspondence mode by hinged supports (4); a closed cavity (36) which is communicated with an air inlet power source is formed in a cylinder (33) of each electric push rod (3); pressure air / hydraulic pressure in the closed cavity (36) acts on a lead screw pair (321) of each electric push rod (3); and the direction of the acting force, which acts on the lead screw pair (321), of the pressure air / hydraulic pressure is opposite to that of the heavy load acting force of the upper platform (1), and the acting force acting on the lead screw pair is used for supporting the lead screw pair (321) pneumatically. According to the six-degree of freedom motion platform, an integrated pneumoelectric push rod mode is adopted, so that the support capacity of the electric push rods is enhanced, and the six-degree of freedom motion platform is simple in structure and low in manufacturing cost.