The invention discloses a pixel structure, its driving method and a display device. The pixel structure is composed of a plurality of RGB sub-pixels with the same shape closely arranged, and each row of sub-pixels is composed of at most two adjacent sub-pixels. A square pixel unit, each sub-pixel in two adjacent rows of sub-pixels is staggered by half a sub-pixel position in the column direction, and the color of each sub-pixel is different from that of adjacent columns. Such a pixel structure, combined with virtual computing, realizes virtual display, that is, through the actual physical position corresponding to the input information, the brightness of the input information is redistributed, and the output is concentrated to the actual physical position. For example, only the pixel unit that displays white pixels is turned on. The three adjacent sub-pixels in the glyph distribution realize white pixel image display, so that the opening of sub-pixels can be flexibly selected without reducing the pixel size, the same information can be displayed with fewer pixels, and the output resolution of the displayed image can be improved .