The invention discloses a multifunctional local nursing anti-infection device. The multifunctional local nursing anti-infection device includes a fixing plate, a soft pad, an inflation balloon, a first flexible pipe, a three-way adjustment valve, an exhaust pipe, a filtering tank, a first filter element, an air inlet pipe, a first connection pipe, a first one-way valve, a fixing air cylinder, a micro motor, a rotation shaft, a cam, a piston, a spring, a filtering screen, a second connection pipe, a second one-way valve, a second flexible pipe, an air cushion ring, a fixing seat, an observation plate, a circulation chamber, air leakage holes, a discharging pipe, a filtering bag, and a second filter element. The multifunctional local nursing anti-infection device is skillful in structure, is powerful in function, can effectively protect a local wound of limbs of a patient from infection, can enhance local air circulation of a body of the patient through a simple operation according to the demands, can satisfy the nursing demands of different patients, can greatly facilitates the nursing operations of medical workers for the patients, and facilitates clinical promotion and application.