551results about "Water/sand/air baths" patented technology

Devices and methods for carrying out a chemical or biochemical protocol are disclosed. In one embodiment, the chemical or biochemical protocol is performed by cycling at least one thermal transfer member between at least two temperatures while liquid samples on which the chemical or biochemical protocol is to be performed are continuously moving through at least one temperature regulated zone upon which the at least one thermal transfer member acts. In some embodiments, the device comprises a sample transport member that comprises liquid samples in sample receiving regions. The sample transport member moves the samples continuously through a temperature regulated zone which cycles between at least two temperatures while the liquid samples are moving through a temperature regulated zone on which at least one thermal transfer member acts. In some embodiments, the sample receiving regions comprise wells, hydrophillic films or hydrophillic filaments.

A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.

Devices and methods for carrying out a chemical or biochemical protocol are disclosed. In one embodiment, the chemical or biochemical protocol is performed by cycling at least one thermal transfer member between at least two temperatures while liquid samples on which the chemical or biochemical protocol is to be performed are continuously moving through at least one temperature regulated zone upon which the at least one thermal transfer member acts. In some embodiments, the device comprises a sample transport member that comprises liquid samples in sample receiving regions. The sample transport member moves the samples continuously through a temperature regulated zone which cycles between at least two temperatures while the liquid samples are moving through a temperature regulated zone on which at least one thermal transfer member acts. In some embodiments, the sample receiving regions comprise wells, hydrophillic films or hydrophillic filaments.

The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

An automated, refrigerated specimen management system (ARSIMS) to hold sealed and / or opened sample / specimen tubes and / or containers that can be in the pre-analytical, in-process, or post-analytical phase of processing. The ARSIMS ensures that each sample / specimen tube, whether it is sealed, capped, closed or open, can be stored at an ideal storage temperature according to the particular phase of processing and as appropriate for the combination of sample / specimen type and analyte(s) to be tested.

The invention relates to a quick variable temperature miniature thermostatic sample cell, which is made of metallic material, an opening is formed in the center of the metallic material and is used as a sample cavity, a light through hole is formed on a metallic shell along the center of the sample cavity, a transparent material is embedded in the light through hole, a Peltier temperature control element is glued on the non-light surface of the metallic material, a groove is arranged on the bottom of the metallic shell for laying aside a temperature sensor, the coat of the metal shell has a heat insulation outer frame, the center of a base connected with the bottom of the heat insulation outer frame is provided with a miniature motor, a small magnet is arranged at the edge of the leaf of a spiral leaf on the shaft of the motor, a stirring magneton is laid aside at the bottom in the sample cavity, the inner wall of the sample cavity and the outer faces of the sensor and the stirring magneton is carried on chemical inertia processing. The invention replaces the water heat conduction with the metal, and changes the system temperature with a thermo-element; the sensor directly observes the temperature of the sample, the heat conduction is speeded up by a miniature electromagnetic stirring system has accelerated; the invention is characterized in having small volume, accurate the temperature measurement, quick variable temperature, and good stability, etc, being able to be placed in analytical instrument such as spectrophotometer, etc., and realizing the quick variable temperature and the accurate thermostatic control of the temperature of the sample.

A constant temperature liquid bath using a thermo-module in which even if an article whose temperature is to be controlled exists in the bath, the temperature of the liquid is efficiently adjusted to a constant value. The liquid bath includes an outer bath storing the liquid, an inner bath disposed in the outer bath through a gap, and including holes in its sidewall through which the liquid flows into the inner bath from the outer bath and an opening at a central portion of its bottom, and an agitator that causes the liquid to flow upward from the opening of the bottom of the inner bath between sidewalls of the inner and outer baths by a rotor blade disposed on a central portion of a bottom between the outer bath and the inner bath. The thermo-module is mounted on an outer surface of the sidewall of the outer bath.

The invention relates to a liquid cooling temperature thermostatic bath system and an intelligent temperature control method thereof, comprising a cooling water tank and a cooling liquid, a liquid bath and a working liquid, and an intelligent temperature controller. The cooling water tank is provided with a water tank temperature sensor and a refrigerator, an electrical heater connected with an electrical heating executor, and a water cooler, a stirrer, a liquid bath temperature sensor, and a water inlet pipe and a water outlet pipe of the water cooler that are connected with the cooling water tank; the other end of the water inlet pipe is connected with a cooling water pump, a signal input end of the intelligent temperature controller is respectively connected with the temperature sensor of the cooling water tank and the temperature sensor of the liquid bath, while the output end is respectively connected with the electrical heating executor, a stirrer engine, the cooling water pump and the refrigerator. The system and the method can drop the temperature at a speed higher than the natural cooling by near 20 times through forced liquid cooling, and can effectively avoid the over regulating of temperature and reduce the negative impact of thermal inertia, thus greatly shortening the precision temperature controlling process and cutting down power consumption.

Provided is a microfluidic device comprising a microfluidic substrate comprising at least one pathway for sample flow; and at least one thermal transfer member which is capable of cycling between at least two temperatures. The thermal transfer member is adapted to heat at least a portion of the sample pathway while a sample is flowing along said at least a portion of said sample pathway. Provided also are methods of carrying out biochemical protocols using such a device.

A sample preparation system provides an automated process that dispenses appropriate amounts of solid material into wells of a microtiter plate for mixing into a suspension. The system utilizes an array of hollow tubes that are lowered into a particle reservoir such that particle material is forced up into the tubes. During loading, solid plungers in the tubes are positioned a known distance from the open end of the tubes. When the particle material is to be dispensed, the plungers are lowered to push the particle material out of the tubes and into receiving wells of the microtiter plate. The plunger stroke and internal diameter of the tubes defines the dispensed volume of particle material.

The invention provides efficiently automated incubation devices that reduce the number of powered moving parts in the devices and the amount of air transfer between environments that are internal and external to the devices. Related systems are also provided.

The invention discloses a fast constant temperature microreactor. The fast constant temperature microreactor comprises a sample cell and at least one sample inlet and outlet arranged on the top of the sample cell, wherein the bottom of the sample cell is provided with an inert slab or a microfluidic chip, the top of the sample cell is provided with an inert thin layer, and a sample cell wall formed by a seal cushion is arranged between the inert slab and the inert thin layer; heatconducting blocks and temperature sensors are arranged on the inert thin layer, and the temperature sensors are covered in the heatconducting blocks; temperature control elements are arranged on the heatconducting blocks, and radiating blocks are arranged on the temperature control elements; the side walls of the heatconducting blocks and the side walls of the temperature control elements are covered by insulating housings; and the sample inlet and outlet of the sample cell is communicated with the outside by pipelines. The microreactor has compact size, can be used as a sample cell for a surface plasma resonator, a resonance light scattering apparatus and other analytical instruments to realize the fast temperature change and the accurate constant temperature control of samples in controlled elements, and can meet the operating requirement of high accuracy measurement on temperature-sensing biological samples.

The present invention provides a constant temperature liquid bath using a thermo-module in which even if an article whose temperature is to be controlled exists in the bath, heat is efficiently exchanged between a heat source and liquid, and the temperature of the liquid is efficiently adjusted to a constant value, and the temperature can easily and swiftly be adjusted. A constant temperature liquid bath which adjusts temperature of liquid in the bath by a heat supply apparatus having a thermo-module that adjusts temperature by Peltier effect comprises an outer bath for storing the liquid, an inner bath disposed in the outer bath through a gap, and provided at its sidewall with holes which the liquid flows into the inner bath from the outer bath and provided with at a central portion of its bottom with an opening, and an agitator which introduces upward the liquid which flows from the opening of the bottom of the inner bath between sidewalls of the inner and outer baths by means of a rotor blade disposed on a central portion of a bottom between the outer bath and the inner bath, the thermo-module is mounted on an outer surface of the sidewall of the outer bath, the temperature of the liquid flowing between the inner and outer baths is controlled to a set value.

Methods and devices for performing chemical reactions under controlled temperatures are described. In one embodiment, the devices provided by the invention comprise a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one thermally conductive temperature-control bladder disposed therein, which bladder is configured to receive a temperature-control substance at a second temperature into said bladder and expel said temperature-control substance from said bladder. The bladder is further configured such that upon receiving the temperature-control substance, the bladder expands to abut substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.

An apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes means for analyzing the effect or proteins and other biological and chemical moieties on the cells. A method for monitoring of proteins and cells. A method for analyzing a cells. An apparatus for aligning light in a well of a plate for holding cells. A method for lighting a well. A method for determining a condition of a cell. An apparatus for indicating a condition of a cell. A method for establishing a focus profile of a plate having wells for holding cells. A method for manipulating cells. An apparatus for manipulating cells.

The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

The invention relates to the fluid thermophysical research field, in particular to the experimental measuring field of fluid thermophysical performance and discloses an experimental platform for the fluid thermophysical measurement. The platform comprises a computer, a constant temperature experimental environment and pressure control system controlled by the computer and a temperature measuring system which is used for fluid to be measured in a thermophysical experiment. The temperature measuring signal is input into the computer. The experimental platform is characterized in that the constant temperature experimental environment comprises a groove body which is filled with constant temperature medium, a heating device for providing energy to the constant temperature medium, a cooling device for providing cold energy to the constant temperature medium, a temperature detection device used for the constant temperature medium and a heat balance control device. The temperature detection device provides the temperature information of the constant temperature medium to the computer. The computer generates decision information to be input into the heat balance control device. And the heat balance control device controls the heating device and the cooling device to provide heat energy or cold energy to the constant temperature medium.

An analyzer comprising: a housing comprising a first space therein; a reagent accommodation section, disposed in the housing, comprising a second space therein for accommodating a reagent container containing a reagent, and an air induction port for inducting air from the first space to the second space; and a cooler for cooling the air which has been inducted from the first space through the air induction port into the second space, is disclosed.

This invention provides methods and systems for precisely and consistently fragmenting and labeling nucleic acid fragments. Time and temperature programmable temperature control modules are used to provide repeatable time / temperature profiles for fragmentation and labeling reactions.

A recirculating bath includes a reservoir for receiving a working liquid, a recirculating pump, and at least one thermal element. The recirculating pump and thermal element are located externally to the reservoir so that the reservoir has an unobstructed working space. The thermal element may be thermally coupled to the working liquid through an interior surface of the reservoir, or the working liquid may be circulated over the thermal element by the recirculating pump in a chamber external to the reservoir. The recirculating bath may also include a lid that provides access to the reservoir by pivoting on a latching hinge. When open, the lid may provide a working surface adjacent to the reservoir. The lid may also include a selector that unlatches the hinge so that the lid can be removed. The recirculating pump may be fluidically coupled to the reservoir via a manifold.

A system for processing laboratory materials is presented which includes a heating apparatus having a heated base portion, a heated lid portion and a cavity. One or more chambers are included which are configured to fit within the cavity of the heating apparatus. Each chamber includes an enclosure, one or more slide racks for holding multiple microscope slides, and an absorbent pad for providing humidity. A solution bath and a micro-tube block are configured to fit within the cavity. A handle is included for attachment to one or more of the racks for transporting the racks from the chamber to the solution bath.

The invention discloses a water-bath constant-temperature oscillator. The water-bath constant-temperature oscillator is technically characterized by comprising a bearing plate, wherein test tube holesare formed in the bearing plate; a test tube is inserted into each test tube hole; a filling part is filled into a gap between each test tube hole and the test tubes of different diameters so as to fasten the test tubes. The water-bath constant-temperature oscillator has the advantage that the easiness in shaking of the test tubes of different diameters is avoided in the oscillation process.

The present invention discloses a constant-temperature groove, which comprises a groove body (1) and is characterized in that the groove body (1) is divided into 2 cavities (2) including a left one and a right one, wherein circulation channels (3) are arranged on the upper end and the lower end between the cavities (2), a stirring oar (4) is arranged inside one of the cavities (2) and connected with an electrical machine (5). The groove body provided by the present invention is divided into 2 cavities, one of which is adopted as the working area, and the other is provided with the stirring oar inside to form a single circulation of the medium, thereby having simple structure, higher technical standard, and the temperature which is much more stable and even. As proved by the test carried out by National institute of metrology, the technical index of the present invention is superior to or meet the national standard, meanwhile the present invention adopts the stirring on the lateral of the working area, thereby preventing the stirring oar of the constant-temperature groove from being damaged by the fallen thermometer used to measure the temperature. The present invention has the advantages of a simple structure, small fluctuation of both the temperature and the maximum temperature difference, and the technical index superior to the national standard, etc.

Thermally-conductive laboratory bath media can be used to replace conventional wet media or dry solid blocks in existing thermal baths for heating or cooling samples with advantageous maintenance and microbial control benefits. The media is typically in the form of metallic or metallic-coated pellets that have rounded edges, hardened surface, a smooth polished finish, and are sized small for efficient thermal communication between pellets and samples. Laboratory bath improvements are disclosed with various advanced controls and adaptations for thermal control as well as infection control.

A portable temperature transfer device for transferring thermal energy to and / or from a laboratory plate is provided as well as its methods of use. The temperature transfer device comprises a base and a raised stage that comprises a thermal conductive material and an encasement that interfaces with the base to create a cavity that encloses a laboratory plate. The raised stage allows direct contact between individual wells of the laboratory plate and the temperature transfer device. The encasement completes the thermally conductive environment for the laboratory plate.

A rotatable vessel includes a rotary member secured to a vessel body and drivable to rotate the vessel about a central axis. The rotary member may be supported by a bearing at a dissolution test apparatus at which the vessel is mounted. The dissolution test apparatus may include a drive system coupled to the rotary member for driving the rotation of the vessel at a desired speed or according to a desired speed profile. The rotation of the vessel agitates media contained in the vessel, thus eliminating the need for a stirring element operating within the vessel.

A liquid thermostatic bath which can also be used as a heat source is characterized in that: the liquid thermostatic bath is divided into a work area and a temperature regulation area, the middle is separated by a metal partition plate with a hole; the interior of the temperature regulation area is provided with an auxiliary heater and a main heater; a diversion barrel is arranged in the work area, the diversion barrel can be welded with a support to be fixed on the metal partition plate with the hole; a stirrer is provided with stirring paddles in both the temperature regulation area and the work area, stirring on the horizontal direction is implemented in the temperature regulation area, stirring on the vertical direction is implemented in the work area, the liquid thereof forms a great annular flow on the vertical direction between the metal partition plate with the hole and the top part of the thermostatic bath; the side wall of the work area is provided with a hole and is welded with a liquid circulating pipeline and a thermostatic liquid output pipeline, the liquid circulating pipeline is connected with a pipeline pump in series and then is connected with a liquid injection pipeline, the liquid injection pipeline extends into the temperature regulation area; the thermostatic liquid output pipeline is further connected with a liquid extraction pump, the liquid extraction pump extracts the thermostatic liquid by the thermostatic liquid output pipeline for external usage, and then the liquid is returned to the liquid injection pipeline after using.