Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for
coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an
alkyl group comprising from 2 to 18
methylene groups. The
alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably,
amide linkages. The hydrophilic
side chain is selected from the group consisting of: a neutral
oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged
oligosaccharide, preferably a negatively charged
oligosaccharide having a weight average molecular weight of less than 10,000; an
oligopeptide of from about 3 to about 30
amino acid residues, said
oligopeptide having an
amino acid sequence which interacts with
protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a
biomaterial are also provided.