Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
30 results about "Pyridine sulfonamide" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Pyridyl sulfonamides as modulators of ion channels
The present invention relates to pyridyl sulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Owner:VERTEX PHARMA INC
Synergistic herbicidal compositions
ActiveCN101102671AEnhanced herbicidal efficacyImprove herbicidal activityBiocideDead animal preservationChemical compositionBULK ACTIVE INGREDIENT
The present invention relates to a synergistic herbicidal composition comprising N- [ [(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl] -2- [2-fluoro- 1 -(methoxymethylcarbony loxy)propyl] -3 -pyridine sulfonamide or N-[[(4,6-dimethoxy-2-pyrimidinyl)amino] carbonyl]-2-[2-fluoro-l-(hydroxy)propyl]-3-pyridine sulfonamide and other herbicidal active materials as active ingredient. The herbicidal composition of the present invention can increase the herbicidal efficacy against major weeds, and can reduce the use amount of active ingredients per unit area, due to the synergistic effect by mixing two herbicidal active ingredient having different physiological functions or different herbicidal activities.
Owner:LG CHEM LTD
Pyridosulfonamide derivatives as p13 kinase inhibitors
Invented is a method of inhibiting the activity / function of PI3 kinases using pyridosulfonamide derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridosulfonamide derivatives.
Owner:GLAXO SMITHKLINE LLC
Method for preparing high-purity torasemide and crystal form I thereof
ActiveCN102702089AOvercome the disadvantages of greater toxicityHigh purityOrganic chemistryIsopropamideGranularity
The invention discloses a method for preparing high-purity torasemide and a crystal form I thereof. The method comprises the following steps of: reacting 4-chloro-3-pyridine sulfonamide and m-toluidine serving as raw materials to obtain 3-sulfamoyl-4-(3-methyl phenyl) aminopyridine, refining, and reacting with 1,1'-carbonyldimidazole and isopropamide, directly introducing isopropyl carbamyl, thus obtaining the high-purity torasemide, wherein the purity (high performance liquid chromatography (HPLC)) of the torasemide is more than 99.5 percent. The prepared torasemide has proper granularity, seed crystal is not required for crystal transformation, the torasemide can be directly transformed into the variant crystal form I, and a chemically pure torasemide variant I is obtained. The preparation method is strong in process controllability, easy and convenient to operate and high in reproducibility, and facilitates industrialized production.
Owner:连云港杰瑞药业有限公司
Triazolopyrimidine sulfonamide compound, and synthetic method and application thereof
ActiveCN103319489ASmall molecular weightThe synthesis method is simpleBiocideOrganic chemistrySulfonyl chlorideChemical compound
The invention provides a triazolopyrimidine sulfonamide compound and synthetic methods and application thereof, relating to a penoxsulam analog and a synthetic method and application thereof. The objective of the invention is to overcome the problems of great synthesis difficulty and high cost of conventional penoxsulam. The triazolopyrimidine sulfonamide compound has a structural formula described in the specification. The method 1 comprises the following steps: 1, preparing 2-methyl-3-chlorobenzenesulfonyl chloride; and 2 preparing a finished product so as to obtain 3-chloro-2-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) benzsulfamide. The method 2 comprises the following steps: 1, preparing 2-mercapto-3-trifluoromethylpyridine; and 2, preparing 3-trifluoromethylpyridine-2-sulfonyl chloride; and 3, preparing a finished product so as to obtain 3-trifluoro-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) pyridine sulfamide. The triazolopyrimidine sulfonamide compound is used as a herbicide in a rice field.
Owner:HEILONGJIANG UNIV
Synergistic herbicidal compositions
ActiveCN101675739AEnhanced herbicidal efficacyImprove herbicidal activityBiocideDead animal preservationChemical compositionBULK ACTIVE INGREDIENT
Owner:LG CHEM LTD
Pyridine sulfonamide phosphate compound as well as preparation method and application thereof
ActiveCN110606860AImprove solubilityImprove stabilityOrganic active ingredientsPhosphorus organic compoundsSolubilityPhosphate
The invention relates to the technical field of biological medicines, and particularly relates to a pyridine sulfonamide phosphate compound as well as a preparation method and application thereof. Thestructure of the pyridine sulfonamide phosphate compound is shown as a formula I shown in the specification. The pyridine sulfonamide phosphate compound has the beneficial effects that the pyridine sulfonamide phosphate compound has the characteristics of high solubility, high stability, convenience in preparation of preparations and the like, is easy to industrially amplify and is used for medical application.
Owner:SHANGHAI XUNHE PHARMA TECH CO LTD
Aqueous suspension herbicidal composition
The object is to prepare an aqueous suspension-type herbicide composition which can avoid the decomposition of a herbicidal sulfonylurea compound in water and can also retain a stable suspension state, without the need of using any complicated step. An aqueous suspension-type herbicide composition comprising: (1) at least one herbicidal sulfonylurea compound selected from the group consisting of 1-[3-[(4,6-dimethoxypyrimidin- 2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate, N-[(4,6-dimethoxypyrimidin-2- yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3- pyridinesulfonamide and salts thereof; (2) an inorganic salt; (3) at least one sulfonate salt selected from the group consisting of an arylsulfonate, an alkylarylsulfonate and formalin condensates thereof; and (4) water.
Owner:ISHIHARA SANGYO KAISHA LTD
Herbicidal suspension concentrate
ActiveUS20140296071A1Improve stabilityBiocideAnimal repellantsBULK ACTIVE INGREDIENTActive ingredient
Owner:ROTAM AGROCHEM INT CO LTD
Preparation of alkyl pyridine-2-sulfonic acid amide
The invention relates to a pharmaceutical intermediate, in particular to a method for preparing a key intermediate 5-alkyl-2-pyridine sulfonamide of pyridine sulfonamide miazines pharmaceutical active species. The method has three steps as follows: firstly, 2-alkyl pyridine chloride reacts with sodium sulfite to produce alkyl pyridine-2-sodium sulfonate; secondly, alkyl pyridine-2-sulfonic acid chloride is produced under the effect of chlorinating reagents and finally, pyridine-2-sulfonic acid amide is produced through amination. The method of the invention is simple in technique, mild in reaction conditions, safe and convenient in operation, easy in acquiring the raw materials, high in product yield and purity, few in three wastes and suitable for industrial production.
Owner:阜新奥瑞凯精细化工有限公司
N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease
Owner:NOVARTIS AG
Water-based herbicidal suspension
Not so many reports on the practical use of herbicidal sulfonylurea compounds have been made since they easily decompose in water or a process for production of their suspensions is complicated. Therefore, it is desired to prepare a water-based herbicidal suspension in which a herbicidal sulfonylurea compound will not decompose in water and excellent suspensibility of which is maintained, without complicated process. A water-based herbicidal suspension comprising (1) a herbicidal sulfonylurea compound (excluding 1-[3-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3-pyridinesulfonamide) or its salt, (2) an inorganic salt, (3) at least one sulfonate selected from the group consisting of an aryl sulfonate, an alkylaryl sulfonate and their formaldehyde condensates and (4) water.
Owner:ISHIHARA SANGYO KAISHA LTD
Pyridin-sulfonamide compounds for the treatment of conditions related to interleukin 1 beta
PendingUS20220002276A1Organic active ingredientsOrganic chemistryDiseaseIdiopathic pulmonary fibrosis
The present invention relates to a novel class of pyridine-sulfonamide compounds and to compositions comprising the same. The compounds and compositions are useful as medicaments in the treatment of diseases responsive to inhibition of IL-1β, such as non-alcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF).
Owner:ALLINKY BIOPHARMA
A kind of preparation method of Vonorazan
The invention relates to a preparation method of vonopraza. The preparation method of the vonoprazan, provided by the invention, comprises the following steps of taking 2-bromo-2'-fluoroacetophenone shown as a formula 3 as a starting raw material; reacting with 3-oxoethyl propionate to generate 4-(2-fluorophenyl)-2-formacyl-4-oxoethyl butyrate shown as a formula 39; then carrying out cyclization reaction on 4-(2-fluorophenyl)-2-formacyl-4-oxoethyl butyrate and pyridine-3-sulfonamide to generate 5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-ethyl formate shown as a formula 40; then carrying out reduction and substation reaction to generate 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methyl methylamine shown as a formula 1, i.e., the vonoprazan. The preparationmethod of the vonoprazan, provided by the invention, has the characteristics of few synthesis steps and high yield.
Owner:迪嘉药业集团股份有限公司
Synergistic herbicidal compositions
ActiveCN101102671BEnhanced herbicidal efficacyImprove herbicidal activityBiocideDead animal preservationChemical compositionBULK ACTIVE INGREDIENT
The present invention relates to a synergistic herbicidal composition comprising N- [ [(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl] -2- [2-fluoro- 1 -(methoxymethylcarbony loxy)propyl] -3 -pyridine sulfonamide or N-[[(4,6-dimethoxy-2-pyrimidinyl)amino] carbonyl]-2-[2-fluoro-l-(hydroxy)propyl]-3-pyridine sulfonamide and other herbicidal active materials as active ingredient. The herbicidal composition of the present invention can increase the herbicidal efficacy against major weeds, and can reduce the use amount of active ingredients per unit area, due to the synergistic effect by mixing two herbicidal active ingredient having different physiological functions or different herbicidal activities.
Owner:LG CHEM LTD
Novel torasemide impurity and preparation method thereof
The invention relates to a novel torasemide impurity and a preparation method thereof. The invention relates to a novel torasemide impurity, namely TL-Imp07: 4-m-toluene amino-N-[(4-m-toluene aminopyridine-3-yl) sulfonyl] pyridine-3-sulfonamide. The preparation method of the TL-Imp07 comprises the steps of carrying out condensation and ammoniation reactions on 4-chloro-3-pyridine sulfonamide. The impurity is novel in structure, is reported for the first time and has great significance on quality control of torasemide crude drugs and preparations. Meanwhile, the preparation method has the advantages of being simple, convenient to operate, high in product purity and the like and can be applied to research of impurity reference substances of torasemide.
Owner:南京恒正药物研究院有限公司
Synergistic weeding composition for paddy field
The invention relates to a synergistic weeding composition for a paddy field. The effective components of the synergistic weeding composition comprise (R)-2-[4(4-cyano-2-fluorophenyloxy)phenyloxy]-butyl propionate and one selected from a group consisting of 3-chloro-2-methyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonic amide and 3-trichloromethyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide, wherein a weight ratio of the effective components is (1-20): (1-10). The synergistic weeding composition exerts synergistic effect on grassy weeds, improves weeding effect and is safe to paddy rice.
Owner:GUANGDONG ZHONGXUN AGRI TECH
Pyridin-sulfonamide compounds for treatment of conditions related to interleukin 1 beta
Owner:ALLINKY BIOPHARMA
Preparation method of 3-ethylsulfonyl-2-pyridinesulfonamide and intermediate thereof
The invention discloses a preparation method of 3-ethylsulfonyl-2-pyridinesulfonamide and an intermediate thereof and provides a preparation method of 3-ethylsulfonyl-2-pyridinethiol. The preparation method of 3-ethylsulfonyl-2-pyridinethiol comprises the following step of carrying out nucleophilic substitution on 2,3-diethylsulfonylpyridine and a thiolation reagent in a solvent to obtain 3-ethylsulfonyl-2-pyridinethiol, wherein the thiolation reagent is a mixture of sodium sulfide and sulfur or sodium hydrosulfide. According to the preparation method disclosed by the invention, cheap 2,3-dichloropyridine is used as a raw material, the reaction step is simple, the total yield is high, and the production cost is greatly reduced; and the preparation method is suitable for industrial production.
Owner:联化科技(上海)有限公司 +3
Pyridine sulfonamides
ActiveUS10668067B2Avoid pollutionPromote absorptionOrganic active ingredientsNervous disorderDiseasePain disorder
Owner:AMGEN INC
Herbicidal suspension concentrate
ActiveUS10206390B2Improve spreading and dispersibilityIncrease the propagation speedBiocideAnimal repellantsBULK ACTIVE INGREDIENTActive ingredient
A herbicidal suspension concentrate composition is provided, the composition comprising at least one pyridine sulfonamide active ingredient and a polyether-polysiloxane. The pyridine sulfonamide compound preferably has the general formula (I):
Owner:ROTAM AGROCHEM INT CO LTD
Weeding composition for paddy field
InactiveCN106070253AExpand the spectrum of weed controlExtended service lifeBiocideAnimal repellantsPaddy fieldBiology
The invention relates to a weeding composition for a paddy field. The effective component of the weeding composition comprises a compound (A) and a compound (B), wherein (A) is 2-chloro-2,6'-diethyl-N-(2-propyloxyethyl)acetanilide, and (B) is one selected from a group consisting of 3-chloro-2-metyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzsulfamide and 3-trifluoromethyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide. The weeding composition has synergistic effect and a broadened weeding spectrum and is applicable to prevention and treatment of weeds in the paddy field.
Owner:GUANGDONG ZHONGXUN AGRI TECH
Triazolopyrimidine sulfonamide compound, and synthetic method and application thereof
ActiveCN103319489BSolve difficultySolve the costBiocideOrganic chemistrySulfonyl chlorideChlorobenzene
A triazolopyrimidine sulfonamide compound and a synthesis method and use thereof; the present invention relates to a penoxsulam analogue and a synthesis method and use thereof. An object of the present invention is to solve the existing problems that the synthesis of penoxsulam is greatly difficult and has high costs. A triazolopyrimidine sulfonamide compound of structural formula (I) or (II); method 1: (1) preparing a 2-methyl-3-chlorobenzenesulfonyl chloride; (2) preparing a finished product, that is to say obtaining 3-chloro-2-methyl-N-(5,8-dimethoxyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-yl)benzene sulfonamide. Method 2: (1) preparing 2-mercapto-3-trifluoromethyl pyridine; (2) preparing 3-trifluoromethyl pyridine-2-sulfonyl chloride; (3) preparing a finished product, that is to say obtaining 3-trifluoromethyl-N-(5,8-dimethoxyl-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridine sulfonamide. The triazolopyrimidine sulfonamide compound is used as a rice field herbicide.
Owner:HEILONGJIANG UNIV
Synergistic weeding composition for paddy field
The invention relates to a synergistic weeding composition for a paddy field. The synergistic weeding composition comprises a compound (A) and a compound (B) in a weight ratio of (1-20): (1-10), wherein (A) is (R)-2-{4-[(6-chloro-2-benzo)oxy]phenoxy}-N-(2-fluorophenyl-N-methylpropanamide), and (B) is one selected from a group consisting of 3-chloro-2-metyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzsulfamide and 3-trifluoromethyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide. The synergistic weeding composition provided by the invention exerts synergistic effect on grassy weeds, improves weeding effect and is safe to paddy rice.
Owner:GUANGDONG ZHONGXUN AGRI TECH
Synergistic weeding composition for paddy field
InactiveCN106070250AExpand the spectrum of weed controlExtended service lifeBiocideAnimal repellantsPaddy fieldPyridine sulfonamide
The invention relates to a synergistic weeding composition for a paddy field. The synergistic weeding composition comprises a compound (A) and a compound (B) in a weight ratio of (10-80): 1, wherein (A) is N-(butoxymethyl)-alpha-chloro-alpha',6'-diethylacetanilide, and (B) is one selected from a group consisting of 3-chloro-2-metyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzsulfamide and 3-trifluoromethyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide. The synergistic weeding composition provided by the invention exerts synergistic effect on grassy weeds, improves weeding effect and is safe to paddy rice. The weeding composition has synergistic effect and a broadened weeding spectrum and is applicable to prevention and treatment of weeds in the paddy field.
Owner:GUANGDONG ZHONGXUN AGRI TECH
Pyridine sulfonamide phosphate compound, preparation method therefor, and use thereof
PendingUS20220169666A1Improve solubilityEasy to manufactureOrganic active ingredientsPhosphorus organic compoundsPhosphoric Acid EstersPhosphate
The present invention relates to the technical field of biomedicine, particularly to a pyridine sulfonamide phosphate compound, a preparation method therefor, and a use thereof. The invention provides the following technical benefits: the pyridine sulfonamide phosphate compound has characteristics of high solubility, high stability, ease of being made into preparations, etc., which is easy to be industrially scaled up for medical use.
Owner:SHANGHAI XUNHE PHARMA TECH CO LTD
Method for preparing high-purity torasemide and crystal form I thereof
The invention discloses a method for preparing high-purity torasemide and a crystal form I thereof. The method comprises the following steps of: reacting 4-chloro-3-pyridine sulfonamide and m-toluidine serving as raw materials to obtain 3-sulfamoyl-4-(3-methyl phenyl) aminopyridine, refining, and reacting with 1,1'-carbonyldimidazole and isopropamide, directly introducing isopropyl carbamyl, thus obtaining the high-purity torasemide, wherein the purity (high performance liquid chromatography (HPLC)) of the torasemide is more than 99.5 percent. The prepared torasemide has proper granularity, seed crystal is not required for crystal transformation, the torasemide can be directly transformed into the variant crystal form I, and a chemically pure torasemide variant I is obtained. The preparation method is strong in process controllability, easy and convenient to operate and high in reproducibility, and facilitates industrialized production.
Owner:连云港杰瑞药业有限公司
Aqueous suspension herbicidal composition
Owner:ISHIHARA SANGYO KAISHA LTD
Application of pyridine sulfonamide phosphate compound in preparation of anti-encephaledema medicine
PendingCN114796241ALower intracranial pressureInhibitory activityOrganic active ingredientsNervous disorderCerebral herniaPhosphoric acid
The invention relates to application of a pyridine sulfonamide phosphate compound or a pharmaceutical composition containing the pyridine sulfonamide phosphate compound in preparation of an anti-encephaledema drug. The pyridine sulfonamide phosphate compound can quickly reduce intracranial pressure, is used for treating encephaledema caused by various reasons and preventing cerebral hernia, is high in safety, has no serious adverse effects such as liver and kidney injury and the like, is expected to become a novel clinical anti-encephaledema medicine, and has a very wide clinical application prospect.
Owner:SHANGHAI XUNHE PHARMA TECH CO LTD
The preparation method of 3-ethanesulfonyl-2-pyridinesulfonamide and its intermediate
The invention discloses a preparation method of 3-ethylsulfonyl-2-pyridinesulfonamide and an intermediate thereof and provides a preparation method of 3-ethylsulfonyl-2-pyridinethiol. The preparation method of 3-ethylsulfonyl-2-pyridinethiol comprises the following step of carrying out nucleophilic substitution on 2,3-diethylsulfonylpyridine and a thiolation reagent in a solvent to obtain 3-ethylsulfonyl-2-pyridinethiol, wherein the thiolation reagent is a mixture of sodium sulfide and sulfur or sodium hydrosulfide. According to the preparation method disclosed by the invention, cheap 2,3-dichloropyridine is used as a raw material, the reaction step is simple, the total yield is high, and the production cost is greatly reduced; and the preparation method is suitable for industrial production.
Owner:联化科技(上海)有限公司 +3
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com