47 results about "Protegrin" patented technology

The invention belongs to the technical field of medicines, and in particular discloses application of an antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome. According to the invention, an antimicrobial peptide Protegrin-1 is chemically synthesized according to an amino acid sequence of reported Protegrin-1 firstly; then, antimicrobial activity of the antimicrobial peptide Protegrin-1 is proved through an escherichia coli resistant DH5 alpha experiment, and researches on the antivirus activity of the antimicrobial peptide to HP-PRRSV are made through qRT-PCR, Western-Blot, cell supernatant TCID50 detection, IFA and other methods; and further the antivirus mechanism of the antimicrobial peptide is explained in virus adsorption and entrance into cell processes. The antimicrobial peptide Protegrin-1 is expected to be used as a novel medicine for preventing and controlling porcine reproductive and respiratory syndrome.

The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

The invention belongs to the technical field of medicines, and in particular discloses application of an antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome. According to the invention, an antimicrobial peptide Protegrin-1 is chemically synthesized according to an amino acid sequence of reported Protegrin-1 firstly; then, antimicrobial activity of the antimicrobial peptide Protegrin-1 is proved through an escherichia coli resistant DH5 alpha experiment, and researches on the antivirus activity of the antimicrobial peptide to HP-PRRSV are made through qRT-PCR, Western-Blot, cell supernatant TCID50 detection, IFA and other methods; and further the antivirus mechanism of the antimicrobial peptide is explained in virus adsorption and entrance into cell processes. The antimicrobial peptide Protegrin-1 is expected to be used as a novel medicine for preventing and controlling porcine reproductive and respiratory syndrome.

The invention discloses D-lactic dehydrogenase SaDLD as well as an encoding gene and application thereof. The protein provided by the invention is derived fromSalinispirillum sp.JHis D-lactic dehydrogenase, is named as SaDLD protein, and is a protein consisting of an amino acid sequence as shown in a sequence 1 in a sequence table. The invention also protects the application of the SaDLD protein as the D-lactic dehydrogenase. The protein has great application prospects in the fields of related medicines, foods, cosmetics and the like.

The invention discloses amidase XAM and its coding gene and application. The protein provided by the present invention is derived from Xinfangfangia sp., is an amidase tag family amidase, named XAM protein, and is a protein composed of the amino acid sequence shown in Sequence 1 in the sequence listing. The invention also protects the use of XAM protein as amidase. The invention also protects the use of XAM protein in the production of hydroxamic acid. The present invention has great application prospects for related medical fields, chemical industry fields and the like.

The invention discloses an acetolactate synthetase inhibitor resistance related protein UVALS and an encoding gene and application thereof. The UVALS protein is the following (a) or (b): (a) protein composed of amino acid sequence shown as sequence 1 in a sequence table, and (b) protein substituted and / or deleted and / or added by one or more amino acid residues of amino acid sequence of the sequence 1, related to the resistance of organism to acetolactate synthetase inhibitor and derived from the sequence 1. The invention further discloses applications of the UVALS protein, including (c1) regulating the resistance of plants to the acetolactate synthetase inhibitor; (c2) promoting the increase of resistance of plants to the acetolactate synthetase inhibitor; (c3) regulating the resistance of microorganism to the acetolactate synthetase inhibitor; and (c4) promoting the increase of resistance of microorganism to the acetolactate synthetase inhibitor. The protein UVALS has high application values to breeding the new variety of plant with high resistance to the acetolactate synthetase inhibitor.

The invention relates to application of Y-39983HCl in antiviral drugs, and belongs to the field of drugs. According to the invention, the NanobiT technology finds that the Y-39983HCl has new functions of inhibition of binding of BST-2 and Vpu protein and inhibition of BST-2 protein degradation; the Y-39983HCl can be used for effectively inhibiting virus infection while protecting the BST-2 protein. The Y-39983HCl has a broad-spectrum inhibition effect on viruses with a BST-2 degradation function, and can be used for research and development of antiviral drugs.

The present invention provides the use of a polypeptide with an amino acid sequence as shown in any one of SEQ ID NO.1 to SEQ ID NO.8 in the preparation of drugs against oral pathogenic bacteria. The invention also provides a medicine against oral pathogenic bacteria and its application. The Protegrin-1 antimicrobial peptide derivatives of the specific sequence of the present invention can specifically kill various oral pathogenic bacteria, and can be used for the treatment and prevention of oral diseases, and the prepared specific preparation has strong stability and has a therapeutic effect on oral diseases. Better, good application prospects.

The invention discloses L-asparaginase SaLA and its encoding gene and application. The protein provided by the present invention is derived from Salinispirillum sp. JH, is a L-asparaginase, named SaLA protein, and is a protein composed of the amino acid sequence shown in Sequence 1 in the sequence table. The present invention also protects the use of SaLA protein as L-asparaginase. The present invention has great application prospects in the related medical fields, food processing fields and the like.

The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups of preferred peptides are derived from the antibiotics protegrin and tachyplesin.

The invention discloses xylanase-m with high heat stability and its coding gene and an application thereof. The protein provided by the present invention is named as xylanase-m, also known as xylanase-m protein, which is as follows (a1), (a2) or (a3): (a1) a protein consisting of 11st to 235th amino acid residues in SEQ ID NO: 1 of a sequence table; (a2) a protein represented by SEQ ID NO: 1 of the sequence table; and (a3) a fusion protein obtained by connecting a label at the N-terminus or / and C-terminus of (a1). The invention also provides an application of xylanase-m protein as xylanase. The invention also provides an application of xylanase-m protein in degrading xylan. The invention also provides an application of the xylanase-m protein in reducing sugar production by taking xylan asa substrate. The xylanase-m can be used in the food industry, animal feed industry and paper bleaching industry, and has great application value.

The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

The invention discloses a HaHSP4 protein of cereal cyst nematode and a coding gene and application thereof. The protein is obtained from the cereal cyst nematode and named the HaHSP4 protein which isthe protein consisting of the amino acid sequence shown in SEQ ID NO:1 in the Sequence Listing. A gene encoding the HaHSP4 protein is named the HaHSP4 gene, and also belongs to the scope of the invention. The invention also provides the application of the HaHSP4 protein. The application includes regulating the host tropism of the cyst nematode; regulating the parasitic capability of the cyst nematode; regulating the pathogenic capability of the cyst nematode; regulating the development of the cyst nematode. The invention also provides a method for cultivating a plant with improved resistance to the cyst nematode. The method comprises the steps of introducing a substance inhibiting the expression of the HaHSP4 protein into a target plant to obtain the plant with the improved resistance to the cyst nematode. The protein has great value for research on the pathogenic mechanism of the cyst nematode and the preparation of anti-nematode plants.