77 results about "Long-term potentiation" patented technology

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation; patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions.

Apparatus and methods for conditional plasticity in a neural network. In one approach, conditional plasticity mechanism is configured to select alternate plasticity rules when performing connection updates. The selection mechanism is adapted based on a comparison of actual connection efficiency and target efficiency. For instance, when actual efficiency is below the target value, the STDP rule may be modulated to increase long term potentiation. Similarly, when actual efficiency is above the target value, the STDP rule may be modulated to increase long term connection depression. The conditional plasticity mechanism dynamically adjusts connection efficacy, and prevents uncontrolled increase of connection weights, thereby improving network operation when processing information of a varying nature.

A method and apparatus for constructing a neuroscience-inspired dynamic architecture (NIDA) for an artificial neural network is disclosed. The method comprises constructing, in one embodiment, an artificial neural network embodiment in a multi-dimensional space in memory such that a neuron is connected by a synapse to another neuron. The neuron and the synapse each have parameters and have features of long-term potentiation and long-term depression. Furthermore, crossover and mutation are employed to select children of parents. Through learning, an initial network may evolve into a different network when NIDA is applied to solve different problems of control, anomaly detection and classification over selected time units. The apparatus comprises in one embodiment a computational neuroscience-inspired artificial neural network with at least one affective network coupled to receive input data from an environment and to output data to the environment.

Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat depression, bipolar disorder, and other mood disorders. Also disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to affect the mood or emotional state of a subject or user. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Potentiation (LTP) or Long-Term Depression (LTD) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.

It is the purpose of this invention to provide methods and systems for non-invasive deep brain neuromodulation using ultrasound for the treatment of anorgasmia, hypo-orgasmia, and for the production of orgasms (Orgasmatron). This can include impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). The ultrasound transducers are attached at fixed positions on a holder. Use of ancillary monitoring or imaging to provide feedback is optional. Control of the ultrasonic transducers includes control of direction of the energy emission, intensity, frequency, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation.

Disclosed are methods and systems and methods for patient-feedback control of non-invasive deep brain or superficial neuromodulation using sound impacting one or multiple points in a neural circuit to produce acute effects and, with application in multiple sessions, Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. One or more of sonic transducer positioning, intensity, frequency, dynamic sweeps, phase/intensity relationships, and firing patterns are changed through feedback from the patient to optimize patient experience through up-regulation or down regulation. Examples are decreases in acute pain or tremor due to more effective impact on the neural targets.

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation; patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions.

The invention discloses a weight adjustment circuit for variable-resistance synapses, which relates to the fields of integrated circuits and neural networks, and is used for carrying out weight adjustment on variable-resistance synapses. The circuit is composed of a weight enhancement adjustment subcircuit A (LTP (long term potentiation) adjustment) and a weight inhibition adjustment subcircuit B (LTD (long term depression) adjustment), wherein the two subcircuits respectively contain a charging pole, a discharging pole, a charge storage pole and an output pole. The core of the circuit is implemented by using an analog circuit mode, therefore, the number of transistors required by the circuit is greatly reduced; and meanwhile, through the setting of the bias voltage on a discharge tube in the discharge pole, the size of a weight adjustment time window can be adjusted conveniently. The circuit disclosed by the invention follows an STDP (spike timing dependent plasticity) learning rule, and LTP and LTD pulse outputs are generated according to the activities of nerve units at the two ends of the variable-resistance synapses so as to carry out corresponding weight adjustment on the variable-resistance synapses. The circuit disclosed by the invention is simple in structure, convenient in parameter adjustment, and suitable for applications, such as weight adjustment on electronic synapses of a large-scale neural network, and the like.

The invention discloses a human face recognition method based on local feature learning, which comprises the following steps of: (a) partitioning a known classified human face sample into blocks, and calculating data of the human face sample of each block through an LBP (Length Between Perpendiculars) operator and an LTP (Long-Term Potentiation) operator to obtain a local histogram vector a of data of the human face sample of each block; (b) performing chi-square histogram distance calculation on local histogram vectors of the same positions on any two different human face samples of the same person in all human face samples to obtain a positive sample feature library; and (c) performing chi-square histogram distance calculation on local histogram vectors of the same positions on any two human face samples of different persons in all human face samples to obtain a negative sample feature library. The human face recognition method based on the local feature learning, provided by the invention, has the advantages of quick response, high accuracy and good recognition effect.

Disclosed are methods and devices for ultrasound-mediated non-invasive deep brain neuromodulation impacting one or a plurality of points in a neural circuit using patterned inputs. These are applicable whether the ultrasound beams intersect at the targets or not. Depending on the application, this can produce short-term effects (as in the treatment of post-surgical pain) or long-term effects in terms of Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. The ultrasound transducers are used with control of frequency, firing pattern, and intensity to produce up-regulation or down-regulation.

Disclosed are methods and systems and methods for neuromodulation of the Reticular Activating System using ultrasound to produce acute effects or Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, pulse duration, frequency, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. The invention can be applied for a variety of clinical purposes such as reversibly putting a patient to sleep or waking them up (for example, for the purpose of anesthesia) or reversibly putting a patient into a coma (for example for the purpose of protecting or rehabilitating the brain of the patient after a stroke or head injury).

Disclosed are methods and systems for treatment planning for deep brain or superficial neuromodulation using ultrasound and other treatment modalities impacting one or multiple points in a neural circuit to produce acute effects or Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. Ultrasound transducers or other energy sources are positioned and the anticipated effects on up-regulation and/or down-regulation of their direction of energy emission, intensity, frequency, firing/timing pattern, and phase/intensity relationships mapped onto the recommended treatment-planning targets. The maps of treatment-planning targets onto which the mapping occurs can be atlas (e.g., Tailarach Atlas) based or image (e.g., fMRI or PET) based. Atlas and imaged-based maps may be representative and applied directly or scaled for the patient or may be specific to the patient.

Disclosed are devices for producing shaped or steered ultrasound for non-invasive deep brain or superficial neuromodulation impacting one or a plurality of points in a neural circuit. Depending on the application this can produce short-term effects (as in the treatment of post-surgical pain) or long-term effects in terms of Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. The ultrasound transducers are used with control of direction of the energy emission, control of intensity, control of frequency for up-regulation or down-regulation, and control of phase/intensity relationships for focusing on neural targets.

Disclosed are methods and systems and methods employing non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier. For example, such an alteration can permit increased penetration of a medication to increase its therapeutic effect. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency (carrier and/or neuromodulation frequency), pulse duration, firing pattern, and phase/intensity relationships for beam steering and focusing on targets and accomplishing up-regulation and/or down-regulation.

Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat movement disorders (e.g., tremor disorders such as Parkinson's Disease and essential tremor, Tourette's Syndrome, and epilepsy). Also included are the Tourette's vocalizations. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training Included is control of direction of the energy emission, intensity, frequency, pulse duration, firing pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.

Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat acute or chronic pain. The neuromodulation can produce acute effects or Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.