31 results about "Hypnotic agent" patented technology

The present invention provides novel compositions for the delivery of hypnotics across the oral mucosa. Specifically, the buffer system in the compositions of the present invention raises the pH of saliva to a pH of greater than about 7.8, thereby promoting substantially complete conversion of the hypnotic agent from its ionized form to its unionized form. As a result, doses of hypnotics are rapidly and efficiently absorbed by the oral mucosa with surprisingly low inter-individual variability. Additionally, delivery of hypnotics across the oral mucosa advantageously avoids hepatic first-pass metabolism of the drug and avoids enzymatic degradation of the drug within the gastrointestinal tract. The invention also provides methods of treating sleep disorders such as insomnia using the compositions of the invention.

Polymorphs of N-methyl-N-(3-ä3-Ä2-thienylcarbonylÜ-pyrazol-Ä1,5- alpha Ü-pyrimidin-7-ylüphenyl)acetamide (Compound (1)), and use of the same as a sedative-hypnotic, anxiolytic, anticonvulsant, and skeletal muscle relaxant agent. Processes for making the same, as well as related compositions and methods are also disclosed, particularly with regard to treatment of insomnia. A polymorph Form I possessing exception physical and heat stability is provided. A polymorph Form II, is also provided.