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33 results about "Endometrosis" patented technology

Endometrosis is a chronic degenerative syndrome of the lining of the uterus (the endometrium) in mares. The cause is unknown, but the severity of endometrosis increases in parallel with the age and number of pregnancies of the mare. Endometrosis is confirmed by histological examination of an endometrial biopsy, which shows degeneration of blood vessels in the endometrium, and fibrosis of the tissue, along with the development of endometrial cysts. These changes cause subfertility; in pregnant mares, the changes in the endometrium can cause the placenta to fail, leading to miscarriage of the foal. Foals which are delivered at full term may be underdeveloped (dysmature). No effective treatment is known.

Chinese medicine oral decoction for treating endometriosis

The invention relates to a medicine for treating endometriosis, in particular to a Chinese medicine oral decoction for treating endometriosis, which is prepared by using Chinese herbal medicines as raw materials. The invention adopts the technical scheme that the Chinese medicine oral decoction comprises the following raw medicinal materials in parts by weight: 4-12g of bupleurum, 4-12g of salvia miltiorrhiza, 4-12g of achyranthes, 5-15g of red paeony roots, 5-15g of pollen typhae, 5-15g of hemlock parsley, 5-15g of barbary wolfberry fruits, 5-15g of herba epimedii and 5-15g of Chinese dodder seeds. In the invention, all the raw medicinal materials are reasonably mixed to achieve the efficacies of promoting blood circulation and removing blood stasis, clearing heat and detoxicating, relieving stasis and stopping pain, removing heat from the blood and dispersing swelling, calming the mind, relaxing bowel, and the like. By oral administration, the Chinese medicine oral decoction can regulate inner body, strengthen the body resistance to consolidate the constitution, regulate endocrine disturbance, enhance immune functions of human bodies, balance yin and yang, restore the Zang-Fu functions in dynamic balance, and effectively treat endometriosis. The invention has the advantages of no side effect, economy, practicability and simple method, and can be prepared independently. The invention is applicable to patients with slight endometriosis accompanied with luteal insufficiency or ovulation failure.
Owner:胡佳顶

Traditional Chinese medicine composition for treating endometriosis and preparation method thereof

The invention provides a traditional Chinese medicine composition for treating endometriosis and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The invention relates to a traditional Chinese medicine composition for treating endometriosis. The traditional Chinese medicine composition is prepared from the following raw materials: Salvia pachysandra, Semen et Herba Lysimachiae, evergreen mucuna root and leaf, ground beetle, rape seed, Artemisia anomala, Salvia chinensis, Rhodiola rosea, Glycyrrhiza foenum-graecum, Polygonum hydropiper root, Rhizoma Corydalis, processed Rhizoma Cyperi, Fructus Toosendan and honey-fried licorice root. The medicine prepared by the invention has the comprehensive effects of promoting blood circulation to remove blood stasis, warming meridians to relieve pain, eliminating mass and resolving masses and tonifying kidney and spleen, promotes blood stasis to dissolve and internally eliminate so as to achieve smoothness, has a unique curative effect on dysmenorrhea, infertility, abdominal mass accumulation and other symptoms caused by endometriosis, can reduce the relapse rate, has an obvious long-term treatment effect and small toxic and side effects, and has a remarkable improvement effect on liver depression and qi stagnation andobstruction of collaterals by blood stasis, and therefore, the traditional Chinese medicine composition has a very good effect on treating the disease.
Owner:浙江养和健康管理科技有限公司

Use of serum microvesicle-asparagine endopeptidase pseudogene 1 in the diagnosis and recurrence prediction of endometriosis

Use of serum microvesicle-asparagine endopeptidase pseudogene 1 in the preparation of a biomarker for diagnosing endometriosis or predicting the recurrence of endometriosis, serum microvesicle-asparagine endopeptide The gene sequence of the enzyme pseudogene 1 is shown in SEQ ID NO.1. Also provided is a kit for diagnosing endometriosis or predicting the recurrence of endometriosis, containing reagents for detecting EV-LGMNP1, including upstream primer sequences, downstream primer sequences and probes, the sequences of which are as shown in SEQ ID NO.5-7. It was found that EV-LGMNP1 could be detected in the serum of patients with endometriosis, and its expression level was significantly higher than that of women without endometriosis, and its expression was significantly increased in patients with recurrent endometriosis. Novel non-invasive biomarkers for the diagnosis of endometriosis, prediction of endometriosis recurrence, and condition monitoring.
Owner:THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV

Pharmaceutical use and pharmaceutical composition of pyrroloquinoline quinine, its derivatives and/or its salts

The present invention relates to the use of pyrroloquinoline quinine (PQQ), its derivatives and / or salts for the preparation of drugs for the treatment and / or prevention of endometriosis including adenomyosis, chocolate cyst of ovary, deeply infiltrating endometriosis and other type of endometriosis. In addition, the present invention relates to the use of PQQ in combination with one or more the following antioxidants: N-Acetyl-L-cysteine (NAC), resveratrol, epigallocatechin gallate, vitamin E or vitamin C for the preparation of drugs for inhibiting the proliferation, oxidative stress status, invasion and migration of endometrial stromal cell. The use of PQQ in combination with NAC shows a synergistic effect on inhibiting cell proliferation: significantly inhibiting the proliferation of endometrial stromal cell in vitro; significantly reducing the damaged size of tissue caused by endometriosis in vivo; significantly reducing the infiltration of endometrial stroma and glands; significantly reducing the dose of NAC as well. PQQ is beneficial for fertility, and increases the chances of getting pregnant. PQQ alone or PQQ in combination with NAC generally shows no side effects and will not interfere with pregnancy.
Owner:NANJING SHUPENG BIOTECH CO LTD

FGFR2c extracellular domain analogue and new application of coding gene thereof

The invention discloses an application of an FGFR2c extracellular domain analogue in preparation of a medicine for preventing and treating endometriosis, and the FGFR2c extracellular domain analogue has a good effect of reducing the size of a mouse endometriosis focus and the fibrosis area, and is superior to that of a gestotrione group. A new means is provided for clinically preparing medicines for treating endometriosis and all diseases related to fibrosis.
Owner:江苏宜仙生物医药有限公司

Traditional Chinese medicine monomer for treating early endometriosis and application thereof

The invention relates to a traditional Chinese medicine monomer for treating early endometriosis and application thereof. The traditional Chinese medicine monomer is ginsenoside Rg3. Results show thatthe ginsenoside Rg3 can inhibit angiogenesis of ectopic endometrium of an endometriosis rat, but does not affect the form of the endometrium in situ, which indicates that physiological blood vesselsare not affected by the ginsenoside Rg3, so that the ginsenoside Rg3 has extremely low toxicity to normal tissues. Therefore, the ginsenoside Rg3 can be applied to early treatment of endometriosis andtreatment of residual lesions in laparoscopic surgery to prevent relapse without hindering ovulation, and conforms to ideal drugs for early treatment and prevention of endometriosis. In addition, ginsenoside Rg3 can obviously lower the level of serum E2 of rats suffering from endometriosis, but has no obvious influence on the serum P level, so that the ginsenoside Rg3 is prompted to adjust the in-vivo endocrine environment by adjusting the in-vivo hormone level, does not affect pregnancy while treatment diseases, is the most effective treatment for EMs, and is high in practicability.
Owner:YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE

Radiolabelled peptide based compounds and uses thereof

The present invention relates to new radiolabelled peptide-based compounds and their use for diagnostic imaging using positron emission tomography (PET). Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
Owner:ENGELL TORGRIM +2

Labeled ligands of Anti-mullerian hormone for diagnosis of endometriosis

The present invention relates to isolated ligands of anti-Mullerian hormone marked so as to be directly detectable by means of magnetic resonance imaging in the endometriosic lesions. In particular, such ligands can be used in a method for diagnosing in vivo endometriosis wherein said method comprises a passage of localizing and / or evaluating the entity of the endometriosic lesions in a patient.
Owner:SIGNORILE PIETRO GIULIO +1

Pharmaceutical use and pharmaceutical composition of pyrroloquinoline quinine, its derivatives and/or its salts

The present invention relates to the use of pyrroloquinoline quinine (PQQ), its derivatives and / or salts for the preparation of drugs for the treatment and / or prevention of endometriosis including adenomyosis, chocolate cyst of ovary, deeply infiltrating endometriosis and other type of endometriosis. In addition, the present invention relates to the use of PQQ in combination with one or more the following antioxidants: N-Acetyl-L-cysteine (NAC), resveratrol, epigallocatechin gallate, vitamin E or vitamin C for the preparation of drugs for inhibiting the proliferation, oxidative stress status, invasion and migration of endometrial stromal cell. The use of PQQ in combination with NAC shows a synergistic effect on inhibiting cell proliferation: significantly inhibiting the proliferation of endometrial stromal cell in vitro; significantly reducing the damaged size of tissue caused by endometriosis in vivo; significantly reducing the infiltration of endometrial stroma and glands; significantly reducing the dose of NAC as well. PQQ is beneficial for fertility, and increases the chances of getting pregnant. PQQ alone or PQQ in combination with NAC generally shows no side effects and will not interfere with pregnancy.
Owner:NANJING SHUPENG BIOTECH CO LTD

S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis

The present invention relates to methods of assessing whether a patient has endometriosis or is at risk of developing endometriosis, to methods of selecting a patient for therapy, and method of monitoring a patient suffering from endometriosis or being treated for endometriosis by determining the amount or concentration of S100A12 in a sample of the patient, and comparing the determined amount or concentration to a reference.
Owner:ROCHE DIAGNOSTICS OPERATIONS +1
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