54 results about "Blood biomarkers" patented technology

The invention provides an active tuberculosis diagnostic marker, a kit and application thereof. The diagnostic marker is characterized by comprising a blood biomarker MCEMP1 protein in a blood sample,the amino acid sequence of the MCEMP1 protein is as shown in the SEQ ID NO:1. The invention further provides the kit capable of rapidly detecting whether a subject suffers from active tuberculosis ornot. The kit comprises a total RNA extraction related reagent in a whole blood sample, a quantitative PCR related reagent and an ELISA related reagent. According to the active tuberculosis diagnosticmarker, the MCEMP1 is adopted as a biomarker for active tuberculosis detection for the first time, is used for clinical diagnosis and differential diagnosis of tuberculosis, and provides a new direction for clinical diagnosis of tuberculosis.

The present subject matter provides, inter alia compositions, systems, kits and methods for diagnosing and treating small vessel diseases (SDVDs).

ADAMTS4 is found to be useful as a blood biomarker for chronic renal failure and also as a therapeutic target for treating chronic renal failure in a human individual. A change in the level of expression of selected genes as disclosed herein in kidney tissue of an individual may also be used to diagnose chronic renal failure in an individual.

The invention discloses a method for testing amyloid precursor protein (APP) in blood. The method comprises the following steps of: firstly, phlebotomizing 2-3ml against the arm into a 1:9 aseptic sodium citrate anti-freezing tube; putting the tube into a refrigerator with the temperature of below 20 DEG C to store; taking 1ml blood when tested; centrifuging under 10000g for 3 minutes; carefully removing supernatant; keeping precipitates for later use; adding 120mu l of protein extracting liquid into cell precipitates to mix in a vortex mode; putting the cell precipitates on ice, standing for 20 minutes and centrifuging under 12000g for 3 minutes; taking supernatant; and performing Western blot experiment and observing a result. According to the invention, the method for identifying Alzheimer's disease (AD) or non-AD is easy, economic and reliable, convenient to detect and relatively easy to operate, and can rapidly obtain an experiment result; the experiment result is clear and easy to analyze; and the method is easy to take materials, the body cannot be wounded by only conventional arm phlebotomizing, the specificity and the sensitiveness of the method for identifying the AD and the non-AD are improved, and the research on new AD blood biomarkers is further developed.