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Preparation method of biological composite material of hydroxyapatite and high polymer

A technology of hydroxyapatite and composite materials, applied in medical science, prosthesis, etc., can solve the problems of no microstructure, poor interface bonding strength, lack of chemical bonding, etc., and achieve improved biomechanical properties and biocompatibility. Improved, high bond strength effect

Inactive Publication Date: 2005-11-02
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] (1) Although the natural biomedical polymers used, such as collagen, hyaluronic acid, and bone morphogenic protein, contain rich biological information, they are not easy to prepare in large quantities and have great differences in performance between batches; while artificially synthesized biomedical polymers such as biological Although degradable aliphatic polylactic acid (PLA), polyglycolic acid (PGA) and their copolymers can be mass-produced, their microstructure, mechanical properties and degradation response can be adjusted, but they lack cell recognition sites
[0004] (2) Hydroxyapatite / polymer biomaterials are mostly prepared by mechanical blending or melt blending method, and the common disadvantages are: ① only mechanical mixing between hydroxyapatite particles and polymer, lack of chemical bonding between the two phases , the interface bonding strength is poor; ②Hydroxyapatite does not form an ordered microstructure in the polymer, which is far from the microstructure of human bone tissue, and cannot provide cells with a microenvironment similar to that of human bone; ③Hydroxyapatite Inhomogeneous dispersion in polymers and disordered orientation of HA lead to poor biomechanical properties of osteoinductive materials, which are only suitable for the replacement of bone tissue in non-bearing parts, and the application is limited

Method used

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  • Preparation method of biological composite material of hydroxyapatite and high polymer
  • Preparation method of biological composite material of hydroxyapatite and high polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] ① Mix benzoyl peroxide, acetone, and acrylic acid in a ratio of 5:24:40 mass percent to prepare a uniform strong oxidizing solution, immerse high-density polyethylene HDPE in the strong oxidizing solution, soak at 50°C for 2 hours, and make the high-density polyethylene A layer of peroxide layer is formed on the surface of ethylene HDPE, and benzoyl peroxide generates free radicals after being heated, triggering acrylic acid to graft onto the molecular chain of high-density polyethylene HDPE; cleaning, filtering, and drying;

[0019] ②Ca(NO 3 ) 2 4H 2 O, NaCl, (NH 4 )H 2 PO 4 and NaHCO 3 Dissolve in deionized water in turn to form a mineralization solution, control the temperature at 37°C, Ca / P=1.67, [Ca 2+ ]=4mmol / L, pH=7.4 or so, solution ionic strength l=0.15mol / L, immerse high-density polyethylene HDPE in the mineralization solution and mineralize for 3 days, filter, wash and dry to obtain HA / HDPE composite powder;

[0020] ③The HA / HDPE biocomposite was prepa...

Embodiment 2

[0022] ① Mix chromic acid, potassium permanganate, hydrogen peroxide and methyl methacrylate at a mass percentage of 5:8:50:100 to make a uniform strong oxidizing solution, immerse high-density polyethylene HDPE in it, and soak for 2 hours at room temperature. Make methyl methacrylate grafted onto the molecular chain of high-density polyethylene HDPE;

[0023] ② KCl, MgCl 2 , CaCl 2 、Na 2 SO 4 、K 2 HPO 4 , NaHCO 3 , NaCl is dissolved in deionized water to form a uniform solution, in which the concentration of each substance is: KCl is 3mmol / L, MgCl 2 1.5mmol / L, CaCl 2 2.5mmol / L, Na 2 SO 4 0.5mmol / L, K 2 HPO 4 1mmol / L, NaHCO 3 4.2mmol / L, NaCl 2mmol / L, use 3-hydroxymethyl-aminomethane and HCl as a buffer solution to maintain pH = 7.4, temperature 37 ° C, immerse high-density polyethylene HDPE in the mineralization solution for 3 days , filtered, washed and dried to obtain HA / HDPE composite powder;

[0024] ③The HA / HDPE biocomposite was prepared by injection molding...

Embodiment 3

[0026] ① Mix benzophenone, acrylic acid, and acetone into a homogeneous solution, immerse high-density polyethylene HDPE in it, soak at 50°C for 24 hours, and then use ultraviolet light (UV) to radiate energy at 7×10 3 Under J radiation, acrylic acid is grafted onto the surface of high-density polyethylene HDPE, cleaned, filtered, and dried;

[0027] ②Ca(NO 3 ) 2 4H 2 O, NaCl, (NH 4 )H 2 PO 4 and NaHCO 3 Dissolve in deionized water in turn to form a mineralization solution, control the temperature at 37°C, Ca / P=1.67, [Ca 2+ ]=4mmol / L, pH=7.4 or so, solution ionic strength l=0.15mol / L, immerse high-density polyethylene HDPE in the mineralization solution and mineralize for 3 days, filter, wash and dry to obtain HA / HDPE composite powder;

[0028] ③The HA / HDPE biocomposite was prepared by injection molding.

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Abstract

The present invention relates to polymer base composite material, and is especially the preparation process of one kind of biological composite hydroxyapatite / polymer material. The composite material is used in repairing and substituting defective bone. The preparation process includes surface grafting modification of high density polyethylene, compounding mineralizing liquid, in-situ mineralizing on the surface of the high density polyethylene with hydroxyapatite and injection forming. The present invention has simple technological process, relaxed requirement in apparatus, high interface binding strength of the prepared composite material, homogeneous distribution and regular orientation of the hydroxyapatite crystal, raised biocompatibility and biological and mechanical performance of the composite material. The composite material has elastic modulus not lower than 18 HPa, tensile strength not lower than 120 MPa and bending strength not lower than 140 MPa.

Description

Technical field: [0001] The invention relates to a polymer matrix composite material, especially a preparation method of a hydroxyapatite (Hydroxy Apatite, abbreviated as HA) / polymer biocomposite material, which is applied to the repair and replacement of bone defects. Background technique: [0002] The repair and replacement of bone defects has been one of the important and popular topics of continuous in-depth research for a century, and bone transplantation has become the second only to blood transfusion in human tissue transplantation in terms of the number of applications. However, because the biocompatibility and mechanical properties of the currently produced biomaterials cannot meet the clinical requirements, the repair and replacement of large-scale bone defects caused by trauma, infection and tumor resection has not been effectively solved so far. At present, the common problems of hydroxyapatite / polymer biocomposites are: [0003] (1) Although the natural biomedi...

Claims

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Application Information

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IPC IPC(8): A61L27/44
Inventor 周科朝黄苏萍李志友朱东波朱晒红
Owner CENT SOUTH UNIV
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