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Solution used for Ribavirin aerosol inhalation, and preparation method of solution

A technology of atomized inhalation and ribavirin, applied in the field of pharmacy, can solve problems such as hidden dangers, waste of remaining drugs, inconvenience and safety, achieve excellent and effective deposition effects, and solve safety problems

Active Publication Date: 2021-10-12
SHIJIAZHUANG DISCOVERY MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the large prescription dose of multi-dose inhalation preparations, it will bring unnecessary waste to the remaining drugs; and it needs to be dissolved or diluted before use, which brings inconvenience and safety hazards to clinical medication.

Method used

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  • Solution used for Ribavirin aerosol inhalation, and preparation method of solution
  • Solution used for Ribavirin aerosol inhalation, and preparation method of solution
  • Solution used for Ribavirin aerosol inhalation, and preparation method of solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] This embodiment provides a single-dose ribavirin nebulized inhalation solution in single-dose independent packaging and prescription. In the prior art, similar products from foreign manufacturers are powders, which are reconstituted and diluted before use, and are inconvenient to use due to the large packaging of 6g / bottle.

[0050] The comparison between the two is shown in Table 1:

[0051] 【Table 1】

[0052]

[0053]

Embodiment 2

[0054] Phospholipid-free ribavirin atomized inhalation solution in the prescription of embodiment 2

[0055] The prescription mix is ​​shown in Table 2:

[0056] 【Table 2】

[0057] prescription Specification: 1ml Specifications: 5ml Specifications: 20ml Ribavirin 200mg 1g 4g Sodium chloride 0.2mg 1mg 4mg Propylene Glycol 0.2mg 1mg 4mg glycerin 0.1mg 0.5mg 2mg egg yolk phospholipids 0mg 0mg 0mg Cyclodextrin 0mg 0mg 0mg Disodium phosphate 0.25mg 1.25mg 5mg Sodium dihydrogen phosphate 0.3mg 1.5mg 6mg 4.5-6.5 4.5-6.5 4.5-6.5 4.5-6.5 Water for Injection Dilute to 1ml Dilute to 5ml Dilute to 20ml

[0058] Preparation process:

[0059] (1) Weigh ribavirin and sodium chloride respectively according to the prescription amount, add them to water for injection with a total volume of 60%, and stir evenly to obtain solution 1:

[0060] (2) In addition, take 30% of t...

Embodiment 3

[0070] Example 3 Ribavirin atomized inhalation solution containing egg yolk phospholipid

[0071] The prescription mix is ​​shown in Table 4:

[0072] 【Table 4】

[0073] prescription Specification: 1ml Specifications: 5ml Specifications: 20ml Ribavirin 200mg 1g 4g Xylitol 0.35mg 1.75mg 7mg Propylene Glycol 0.2mg 1mg 4mg glycerin 0.1mg 0.5mg 2mg egg yolk phospholipids 0.2mg 1mg 4mg Cyclodextrin 0mg 0mg 0mg Disodium phosphate 0.25mg 1.25mg 5mg Sodium dihydrogen phosphate 0.3mg 1.5mg 6mg 4.5-6.5 4.5-6.5 4.5-6.5 4.5-6.5 Water for Injection Dilute to 1ml Dilute to 5ml Dilute to 20ml

[0074] Preparation process:

[0075] 1) Weigh ribavirin and xylitol respectively according to the prescription amount, add them to water for injection with a total volume of 60%, and stir evenly to obtain solution 1:

[0076] 2) In addition, take 30% of the prescribed amount of...

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Abstract

The invention discloses a solution used for Ribavirin aerosol inhalation, and a preparation method of the solution. Each ml of the solution used for the Ribavirin aerosol inhalation comprises: 1) 0.005-5 g of Ribavirin or pharmaceutically acceptable salts thereof, 2) 0.1-0.5 mg of isotonic agent, 3) 0.2-0.8 mg of buffer salt, 4) 0.3-4.0 mg of penetration enhancer, 5) 0-50 mg of cyclodextrin, 6) 0.1-1.0 mg of solvent, and the balance of water for injection. According to the invention, phospholipid is innovatively used as the penetration enhancer, so that the solubility of the medicine in a liquid state is improved, and the penetration enhancer improves a delivery ratio in the respiratory tract, especially in pulmonary alveoli, and accelerates absorption. The medicine preparation provides a treatment medicine and a treatment scheme which are lacked in the prior art and have the advantages of an accurate medicinal dosage, high and stable medicine quality and safe, simple and convenient clinical application.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a ribavirin solution for nebulized inhalation and a preparation method thereof. Background technique [0002] Ribavirin is a synthetic chemical substance, also known as ribavirin, ribavirin, niscor, etc. It is a broad-spectrum and powerful antiviral drug, which belongs to synthetic nucleoside drugs. It is effective for many DNA and RNA The virus has an inhibitory effect and was successfully synthesized for the first time by Witkowski et al. in 1970 by ICN Pharmaceuticals. It is a nucleoside drug with broad-spectrum antiviral activity. It has a strong inhibitory effect on influenza virus, herpes virus, adenovirus and measles. It can competitively inhibit inosine monophosphate dehydrogenase and hinder the replication of viral nucleic acid. synthesis. The dosage forms of ribavirin marketed abroad are oral dosage forms and spray dosage forms, while domestic injection dosage form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/08A61K47/24A61K31/7056A61P31/16A61P31/22A61P31/14A61P31/20
CPCA61K9/0078A61K9/08A61K47/24A61K31/7056A61P31/16A61P31/22A61P31/14A61P31/20Y02A50/30
Inventor 张哲峰侯雯赵海峰
Owner SHIJIAZHUANG DISCOVERY MEDICINE TECH CO LTD
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