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Gel plaster for treating insomnia and preparation method thereof

A technology of gel and paste, applied in the field of traditional Chinese medicine, to achieve the effect of less skin irritation, no liver and kidney side effects, and fixed absorption area

Active Publication Date: 2020-09-11
INST OF ACUPUNCTURE & MOXIBUSTION CHINA ACADEMY OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, the existing problems in the prior art are: in the prior art, the gel plaster for the treatment of insomnia using Yintang and Yongquan as a combination of acupuncture points and different traditional Chinese medicine prescriptions has not been reported yet.

Method used

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  • Gel plaster for treating insomnia and preparation method thereof
  • Gel plaster for treating insomnia and preparation method thereof
  • Gel plaster for treating insomnia and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0038] as attached figure 1 As shown, the preparation method of Yintang gel plaster provided by the embodiment of the present invention comprises the following steps:

[0039] S101, Extraction and refinement: Weigh 10 prescription quantities of medicinal materials, and extract them twice with water, the first time is 10 times of water, the second time is 8 times of water, and the time of both extractions is 1 hour.

[0040] S102, combine the two water extracts, concentrate in a water bath until the medicinal material: medicinal solution = 1:1, use 2 times the amount of 95% ethanol for alcohol precipitation, place at 4°C for 16 hours, pour out the supernatant to obtain a flow immersion paste.

[0041] S103, recover the ethanol from the supernatant obtained in S102 until it has no alcohol smell, concentrate in a water bath at 50° C. to a substrate with a relative density of 1.18-1.20, and set aside.

[0042] S104, preparation of Yintang gel paste: add the liquid extract prepar...

Embodiment 1

[0048] Embodiment 1: Yintang gel plaster

[0049] 1. Yintang gel plaster base formula

[0050] Hydroxypropyl methylcellulose 1~8g, bone gelatin B1~18g, refined peach gum 1~20g, sodium carboxymethylcellulose 1~15g, carbomer 9402~20g, sodium polyacrylate NP-7002~20g , glycerin 20-150g, iron powder 0.1-0.4g, tartaric acid 0.01-0.1g, water 30-270g, propylene glycol 5-15g.

[0051] 2. Preparation process of Yintang gel plaster

[0052] 2.1 Drug extraction

[0053] Weigh 200g of raw pinellia, sorghum rice (sorghum rice), raw keel, raw oyster, pig iron root, white peony root and raw jujube kernel (2:4:2:2:1:2:1), and extract 2 times with water, 10 times of water for the first time, 8 times of water for the second time, and the time of two extractions is 1 hour; the two water extracts are combined, and the water bath is concentrated to the medicinal material: when the medicinal solution=1:1, use 2 times the amount (weight Alcohol precipitation with 95% ethanol, place at 4°C for 16...

Embodiment 2

[0063] Example 2: Yongquan gel plaster

[0064] 1. Yongquan Gel Plaster Base Formula

[0065] Hydroxypropyl methylcellulose 1-8g, stearic acid 2-8g, bone gelatin B1-18g, refined peach gum 1-20g, carboxymethylcellulose sodium 1-15g, carbomer 9402-20g, spit Temperature 802~5g, sodium polyacrylate NP-8002~20g, glycerin 50~200g, aluminum potassium sulfate 0.1~0.4g, citric acid 0.01~0.1g, water 30~270g, polyethylene glycol 4005~15g

[0066] 2. Preparation process of Yongquan gel patch

[0067] 2.1 Drug extraction

[0068] Weigh raw Evodia rutaecarpa, raw mugwort leaves, raw Sichuan pepper 1:1:1200g, extract twice with 7 times the amount of 80% ethanol, 1.5 hours each time. Combine the alcohol extracts, recover ethanol until there is no alcohol smell, concentrate in a water bath at 50°C to a relative density of 1.18-1.20, and set aside.

[0069] 2.2 Matrix preparation

[0070] (1) Carbomer 9402.5g, bone gelatin B1.5g, refined peach gum 3.5g, hydroxypropyl methylcellulose 3.5g, ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a gel plaster for treating insomnia and a preparation method thereof. The gel plaster for treating insomniacomprises a Yintang gel plaster and a Yongquan gel plaster, wherein the Yintang gel plaster is prepared from dried pinellia, glutinous millet, raw dragon's bone, raw oyster shell, pig iron, white peony root, and raw jujube kernel, and the Yongquan gel plaster is prepared from raw evodia fruit, raw argyi leaf, and raw Sichuan pepper. The gel plaster for treating insomnia provided by the invention is a patch for external use composed of hydrophilic polymer materials. Compared with oral dosage forms, the gel plaster has no liver first pass effects, no harms to the spleen and stomach, and no toxicand side effects on the liver and kidney, is not affected by the degradation of the gastrointestinal tract, and has high bioavailability; compared with injections, the gel plaster is convenient to use, non-invasive, and painless; compared with ointments, the gel plaster has accurate administered dose and a fixed absorption area; and compared with rubber pastes, the gel plaster has no sensitization which may be caused by rosin and other thickeners, and has less irritation to the skin.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a gel plaster for treating insomnia and a preparation method thereof. Background technique [0002] Insomnia is a common clinical disease. According to statistics, about 30-35% of the world's population has symptoms of sleep difficulties, and more than about 10% have chronic insomnia. my country's recent statistics show that the incidence of insomnia is as high as 40%, and there is a younger trend. In addition to easily causing multiple organ dysfunction and decreased immune function, it is also a high-risk factor for mental disorders. Long-term insomnia is harmful to human physical and mental health and seriously affects the quality of life. [0003] Insomnia intervention is mainly based on western medicine. Western medicine is mainly divided into: benzodiazepine receptor agonists, melatonin receptor agonists, orexin receptor antagonists and ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/758A61K9/70A61P25/20A61K35/02A61K35/618A61K33/26
CPCA61K9/7023A61K33/26A61K35/02A61K35/618A61K36/282A61K36/65A61K36/71A61K36/725A61K36/754A61K36/758A61K36/8888A61K36/899A61K47/42A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P25/20A61K2300/00
Inventor 焦玥杜茂波刘兵
Owner INST OF ACUPUNCTURE & MOXIBUSTION CHINA ACADEMY OF CHINESE MEDICAL SCI
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