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A hydroxyapatite porous ceramic with controllable macroscopic and microscopic structures, its preparation method and application

A technology of hydroxyapatite and microstructure, which is applied in the direction of ceramic products, applications, and other household appliances, etc., which can solve the problems that are difficult to meet the regulation, and the internal microstructure of deposited materials cannot be intervened and designed, so as to achieve the effect of enhancing mechanical properties

Active Publication Date: 2022-01-04
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an immature technology, the scientific and technological research of 3D direct writing is still in its infancy. In addition, 3D direct writing printing ink needs to flow out of fine nozzles without clogging, and can be quickly solidified to a certain strength. The filaments are used in various shapes; therefore, 3D direct writing ink must have both shear thinning and viscoelasticity, such as elastic modulus exceeding loss modulus
[0005] 3D direct writing technology can realize arbitrary design and structure on the macrostructure of materials. However, it cannot intervene and design the internal microstructure of deposited materials. Therefore, it is difficult to meet the requirements of regulating the microporosity of materials in practical applications. Freezing casting is a method widely used to manufacture microporous materials, which can realize the directional arrangement of the microporous materials and the regulation of pore size, pore shape and porosity.
[0010] However, there is no research on the combination of 3D direct writing technology and freeze casting method to prepare porous hydroxyapatite ceramics.

Method used

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  • A hydroxyapatite porous ceramic with controllable macroscopic and microscopic structures, its preparation method and application
  • A hydroxyapatite porous ceramic with controllable macroscopic and microscopic structures, its preparation method and application
  • A hydroxyapatite porous ceramic with controllable macroscopic and microscopic structures, its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] In the slurry, the solid content (solid phase volume fraction) of hydroxyapatite is 10vol.%, the gelling agent is gelatin, and the content is 5wt.% of the solvent mass, and the solvent is water; the dispersant is ammonium polyacrylate , the addition amount is 0.6wt.% of the mass of hydroxyapatite. Firstly, the hydroxyapatite powder, water and dispersant are mixed and ball milled at 30 rpm for 12 hours to form a suspension, and zirconia balls are added as grinding Medium, while adding 1-2 drops of n-octanol as a defoamer. Subsequently, gelatin, a gelling agent, was added to the hydroxyapatite suspension, followed by ball milling at a temperature of 60°C for 2 hours to obtain a slurry, which was then poured into a syringe of a 3D direct writing device and left to stand at 0°C. Set aside for 5 minutes to promote the transformation of the suspension into a gel, then put the syringe loaded with hydroxyapatite gel into a 210 μm needle nozzle, and perform direct writing moldin...

Embodiment 2

[0091] In the slurry, the solid content of hydroxyapatite is 40vol.%, the gelling agent is gelatin, and the content is 15wt.% of the solvent mass, and the solvent is water; the dispersant is ammonium polyacrylate, and the addition amount is hydroxyphosphorus 1.2wt.% of the mass of limestone, first mix hydroxyapatite powder, water and dispersant, form a suspension after ball milling in a ball mill at 60rpm for 8 hours, add zirconia balls as grinding media, and simultaneously add 1- 2 drops of n-octanol as a defoamer. Subsequently, gelatin gelatin was added to the hydroxyapatite suspension, followed by ball milling at a temperature of 80°C for 2 hours to obtain a slurry, which was then poured into the syringe of a 3D direct writing device and left to stand at 0°C. Leave it for 2 minutes to promote the transformation of the suspension into a gel, then put the syringe loaded with hydroxyapatite gel into a 160 μm needle nozzle, and perform direct writing molding of the slurry on th...

Embodiment 3

[0093] In the slurry, the solid content of hydroxyapatite is 20vol.%, the gelling agent is gelatin, and the content is 10wt.% of the solvent mass, and the solvent is water; the dispersant is ammonium polyacrylate, and the addition amount is hydroxyapatite 1.2wt.% of the stone mass, first mix the hydroxyapatite powder, water and dispersant, and then ball mill at 60rpm for 8 hours to form a suspension, add zirconia balls as grinding media, and add 1-2 Drops of n-octanol were used as defoamers. Subsequently, gelatin gelatin was added to the hydroxyapatite suspension, followed by ball milling at a temperature of 80°C for 2 hours to obtain a slurry, and then the suspension was poured into the syringe of a 3D direct writing device and left at 0°C Leave it for 3 minutes to promote the transformation of the suspension into a gel, then put the syringe loaded with hydroxyapatite gel into a 400 μm needle nozzle, and perform direct writing molding of the slurry on the thermally conductive...

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Abstract

The invention discloses a hydroxyapatite porous ceramic with controllable macroscopic and microscopic structures and its preparation method and application. The hydroxyapatite porous ceramic first obtains a three-dimensional structure through 3D direct writing molding, and then freezes it by casting The microporous structure is regulated and controlled, and the preparation method is disclosed as adding raw material A to a solvent containing a dispersant and mixing to obtain a suspension, and then adding a gelling agent to the suspension and mixing to obtain a slurry; the raw material A contains hydroxyphosphorus Limestone powder, pass the slurry through the 3D direct writing equipment, and control the slurry to be in a gel state when passing through the direct writing equipment, print and freeze to obtain a green body with a three-dimensional structure, the green body is freeze-dried, and sintered to obtain a macroscopic The hydroxyapatite porous ceramics with controllable microstructure, the invention is the first to realize the efficient combination of direct writing molding and freeze casting technology; the obtained hydroxyapatite porous ceramics can be used as bone scaffolds, which can meet the customization of different bone tissues need.

Description

technical field [0001] The invention relates to a hydroxyapatite porous ceramic with controllable macroscopic and microscopic structures, a preparation method and application thereof, and belongs to the field of three-dimensional structural material molding. Background technique [0002] Hydroxyapatite (HA) is a major component of natural bone. Among them, hydroxyapatite accounts for 75% of the weight of the whole bone tissue, and it is safe and non-toxic after being implanted in the body. HA ceramics can make bone cells attach to their surface and induce bone growth, and are widely used as bone substitutes for bone grafting. As far as the structure of bone substitute materials is concerned, dense substitute materials are more convenient in clinical use due to their certain processability, but because they can only form bone on the surface after implantation in animals, they lack bone induction. The ability to form, only serves as a scaffold for new bone formation. Porous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/00C04B35/447A61L27/10A61L27/12A61L27/50A61L27/56B33Y10/00B33Y70/10
CPCA61L27/10A61L27/12A61L27/50A61L27/56C04B35/447C04B38/0045B33Y10/00B33Y70/00A61L2430/02
Inventor 张斗廖晶晶苏波
Owner CENT SOUTH UNIV
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