Tubular scaffold with double-layer structure and preparation method thereof

Abstract

The invention discloses a tubular scaffold having a double-layer structure, wherein the double-layer structure comprises an outer layer and an inner layer, wherein the outer layer is a dense layer having a first porosity and the inner layer is a porous layer having a second porosity; The dense layer and the porous layer are connected into one body through an interpenetrating polymer network structure formed between the polymers; And the first porosity is smaller than the second porosity. The invention also discloses a method for preparing the tubular scaffold by a one-step method. The tubularscaffold of the invention is integrally formed, wherein the inner layer can promote tissue growth and induce tissue regeneration, the outer layer has anti-adhesion effect, and the tubular scaffold hasthe advantages of good mechanical properties, tight connection between layers, soft hand feeling after wetting, and the like. In addition, the preparation method of the tubular scaffold of the invention has the advantages of simple process, easy operation and the like.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a tubular stent with a double-layer structure and a preparation method thereof. Background technique [0002] In the early days, autologous tissue transplantation or suture was mostly used for the repair of ductal tissues or organs, such as nerves, esophagus, tendons, blood vessels, and ureters. , and direct suture will lead to uneven tubular tissue structure and mechanics, and the treatment effect is not satisfactory. [0003] With the development of new materials and technologies, some tubular tissues such as artificial blood vessels have gradually replaced autologous tissue transplantation, but other artificial tubular tissues have various defects and are difficult to meet clinical needs. [0004] For example, CN1762505A used electrospinning technology to develop a catheter stent. This method is complicated to operate and needs to go through different processing st...

AI Technical Summary

Problems solved by technology

This method is complicated to operate and needs to go through different processing stages. Due to the characteristics of spinning itself, it cannot provide a reasonable three-dimensional space structure, and it is difficult to realize the role of three-dimensional support and provide a reasonable space.

In view of the inherent shortcomings of this technology, the prepared catheter stent is thin, has poor mechanical properties, and is difficult to match with human tubular tissues. Although it has good biocompatibility and can promote tissue ingrowth, it is also easy to cause damage to other tissues. Peripheral tissue grows together, causing adhesions and affecting the movement of tubular tissue

[0005] For another example, CN103169546A discloses a catheter stent for nerve repair prepared by polylactic acid and polycaprolactone. Although it has high mechanical strength, the catheter stent made by combining natural air drying and freeze drying feels hard and is easy to damage tissues.

[0006] In addition, although there are tubular stents or membranous repair products with a double-layer structure in the prior art, they are all prepared layer by layer, and the bonding between layers is prone to weak bonding and delamination.

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