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EV71 virus and CVA16 virus inhibitor (TJAB-1099) oral solution and preparation method thereof

A technology for CVA16 and virus inhibitors, which is applied in the field of oral solutions of EV71 virus and CVA16 virus inhibitors and its preparation, can solve the problems of limiting oral absorption rate, clinical application and dosage form development limitations, and achieve easy dosage and increase Bioavailability, rapid-acting effect

Inactive Publication Date: 2018-02-23
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, TJAB-1099 is a water-insoluble compound, and its water solubility limits its oral absorption rate, which greatly limits its clinical application and dosage form development

Method used

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  • EV71 virus and CVA16 virus inhibitor (TJAB-1099) oral solution and preparation method thereof
  • EV71 virus and CVA16 virus inhibitor (TJAB-1099) oral solution and preparation method thereof
  • EV71 virus and CVA16 virus inhibitor (TJAB-1099) oral solution and preparation method thereof

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preparation example Construction

[0024] The method for preparing the oral solution of EV71 virus and CVA16 virus inhibitor (TJAB-1099) provided by the invention may further comprise the steps:

[0025] First, EV71 virus and CVA16 virus inhibitor (TJAB-1099) were dissolved in a solvent to prepare a mixed solution. Wherein, the solvent includes a combination of one or more of polyethylene glycol, glycerin and Tween, and ethanol and water. In this step, dissolve TJAB-1099 in ethanol, stir until completely dissolved, add glycerin, polyethylene glycol or Tween, mix well, and then add water to dissolve TJAB-1099 in the solvent. In this step, the solvent includes a mixture of 5% to 25% polyethylene glycol (if any), 5% to 30% glycerin (if any), and 1% to 20% Tween (if any). A combination of one or more and 10% to 50% ethanol and 10% to 50% water. Among them, 200-300 mg of TJAB-1099 is dissolved in 100 mL of solvent.

[0026] Second, add auxiliary materials to the above mixed solution. Among them, auxiliary materi...

Embodiment 1

[0031] Embodiment 1: the preparation of the oral solution of EV71 virus and CVA16 virus inhibitor (TJAB-1099)

[0032] Weigh 0.25g of TJAB-1099 raw material, add 42ml of ethanol, stir until TJAB-1099 is completely dissolved, continue to add 14mL of Tween, stir evenly, add distilled water to 100mL, add sodium citrate to adjust the pH to 8.0. Slowly add 0.02g of β-carotene and 0.02g of sorbitol to the above solution and stir until completely dissolved; subpackage and label.

Embodiment 2

[0033] Embodiment 2: Preparation of the oral solvent of EV71 virus and CVA16 virus inhibitor (TJAB-1099)

[0034] Weigh 0.25g of TJAB-1099 raw material, add 42ml of ethanol, stir until TJAB-1099 is completely dissolved, continue to add Tween 80 5mL, PEG400 17mL; stir well, add distilled water to 100mL, add potassium carbonate to adjust the pH to 7.8. Slowly add 0.05g tartrazine and 0.01g sodium saccharin to the above solution and stir until completely dissolved; subpackage and label.

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Abstract

The present invention provides an EV71 virus and CVA16 virus inhibitor (TJAB-1099) oral solution and a preparation method thereof. The preparation method comprises: dissolving TJAB-1099 in a mixed solvent, wherein the mixed solvent comprises a combination comprising one or a plurality of material selected from polyethylene glycol, glycerol and Tween, ethanol and water; and adding a pharmaceutically acceptable auxiliary material to prepare the TJAB-1099 oral solution. According to the present invention, the preparation process is simple; and the prepared TJAB-1099 oral solution has advantages of high drug dispersion, uniform-dispersed effective components, rapid absorption, rapid action, easy sub-dosing, high bioavailability, good taste, easy taking and good compliance, is suitable for children and the elderly, and can be widely used as the anti-virus drug for hand-foot-and-mouth diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an oral solution of an EV71 virus and CVA16 virus inhibitor (TJAB-1099) and a preparation method thereof. Background technique [0002] Human hand-foot-mouth disease (HFMD) is a common acute infectious disease and is distributed all over the world. The incubation period of hand, foot and mouth disease is 2-10 days, with an average of 3-5 days, and the course of disease is generally 7-10 days. Fever symptoms appear at the onset of the disease, scattered herpes appear on the oral mucosa, maculopapules and herpes appear on the hands, feet and buttocks, and there may be inflammatory flushes around the herpes, and there is less fluid in the pustules. Accompanied by cough, runny nose, loss of appetite and other symptoms. In a small number of cases, especially children with EV71 infection, meningitis, encephalitis, encephalomyelitis, neurogenic pulmonary edema, and circulatory disorders may oc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4439A61K47/10A61K47/26A61P31/14
CPCA61K9/0095A61K31/4439A61K47/10A61K47/26
Inventor 饶子和杨诚郭宇马海秋蔡岩王淑艳汪颖张玉普张金敏李玉彩左臣强
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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