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Preparation method of degradable magnesium alloy and degradable polymer composite

A technology for degrading polymers and composite materials, applied in the field of preparation of degradable magnesium alloys and degradable polymer composite materials, can solve the problem of low mechanical properties of degradable polymers, limited strength of composite materials, low elastic modulus and strength, etc. Problems, achieve the effect of shortening recovery time, increasing biological activity, and improving strength

Inactive Publication Date: 2017-02-22
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The modulus of elasticity of porous titanium or titanium alloy is very close to that of human bone, and its mechanical properties can be adjusted. It has good potential for orthopedic applications, but due to its low elastic modulus and strength, it cannot meet the needs of bone implants that require high mechanical properties. However, the strength of the composite material is mainly adjusted by changing the diameter and porosity of the titanium wire. When it is wound into a skeleton with a large pore diameter and a large porosity, its strength is low, resulting in limited strength of the composite material.
[0004] The biodegradable polymers currently used clinically have low mechanical properties and are only suitable for fractures of cancellous bone and non-bearing bone or internal fixation in osteotomy, and cannot meet the clinical needs of human cortical bone or complete load-bearing bone fixation. Therefore, narrow range of applications

Method used

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  • Preparation method of degradable magnesium alloy and degradable polymer composite

Examples

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Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of a degradable magnesium alloy and a degradable polymer composite material, characterized in that it comprises the following steps:

[0025] 1) Using degradable metal magnesium as the metal substrate, and performing 3D drilling on the degradable metal magnesium, so that the degradable metal magnesium metal substrate is covered with three-dimensional through pores with a pore size of 0.3mm and a porosity of 35%;

[0026] 2) Put the metal substrate covered with three-dimensional penetrating pores into a closed injection mold, and press the molten degradable polymer polylactic acid (PLA) into the degradable magnesium by injection molding at a temperature of 180°C. In the three-dimensional penetrating pores of the metal substrate;

[0027] 3) Place it for 3-10 minutes at a temperature of 180°C and a pressure of 20 MPa. After demoulding and cooling, remove the polylactic acid (PLA) outside the holes of the metal magnesium substrate to obtain a mixture o...

Embodiment 2

[0030] A method for preparing a composite material of a degradable magnesium alloy and a degradable polymer, characterized in that it comprises the following steps:

[0031] 1) The degradable magnesium alloy Mg-0.5Zr-1Ca is used as the metal substrate, and the degradable magnesium alloy is processed so that the metal substrate of the degradable magnesium alloy is covered with three-dimensional through pores;

[0032] 2) Put the metal substrate of the degradable magnesium alloy Mg-0.5Zr-1Ca covered with three-dimensional penetrating pores into a closed injection mold, and melt the degradable polymer polyglycolic acid at a temperature of 240 ° C (PGA) is pressed into the three-dimensional penetrating pores of the metal substrate of the degradable magnesium alloy Mg-0.5Zr-1Ca by extrusion;

[0033] 3) Place it for 3-10 minutes at a temperature of 240°C and a pressure of 20 MPa. After demoulding and cooling, remove the polymer polyglycolic acid (PGA) outside the hole of the magne...

Embodiment 3

[0036] A method for preparing a degradable magnesium alloy and a degradable polymer composite material, characterized in that it comprises the following steps:

[0037] 1) The degradable magnesium alloy Mg-1Mn-2Zn-1Nd alloy is used as the metal substrate, and the degradable magnesium alloy is subjected to 3D drilling treatment, so that the metal substrate of the degradable magnesium alloy is covered with pores with a diameter of 0.2mm and a porosity of 21% three-dimensional through pores;

[0038] 2) Put the metal substrate covered with three-dimensional penetrating pores into a closed injection mold, and press the melted degradable polymer L-polylactic acid (PLLA) into the degradable material by injection at a temperature of 200°C. In the three-dimensional penetrating pores of magnesium alloy;

[0039] 3) Place it for 0.3-1 minute at a temperature of 200°C and a pressure of 100 MPa. After demoulding and cooling, remove the polymer L-polylactic acid (PLLA) outside the hole of...

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Abstract

The invention provides a preparation method of a degradable magnesium alloy and degradable polymer composite. Degradable magnesium or a degradable magnesium alloy is taken as a metal substrate and processed, and three-dimensional through pores in different shapes and with different porosity are densely formed in the metal substrate adopting the degradable magnesium or the degradable magnesium alloy. The degradable magnesium or the degradable magnesium alloy is taken as a substrate material and tightly combined with a degradable polymer through the crossed through three-dimensional pores, the overall mechanical properties of the composite are far higher than those of a single degradable polymer, the composite can meet requirements of most applications such as bone filling, bone repair, bone transplantation and the like, the medical magnesium or the medical magnesium alloy is degraded in a human body fluid corrosion environment, calcium deposition and osteocyte formation can be promoted, bone healing can be accelerated, and the biological activity is improved; the composite can form porous tissue automatically in a degradation process, ingrowth of new bone tissue and propagation of osteocytes are facilitated, and rehabilitation time of bone tissue is shortened.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of a degradable magnesium alloy and a degradable polymer composite material. Background technique [0002] Orthopedic implant materials have become an indispensable material for bone grafting, bone defect filling and repair operations. Stainless steel, cobalt-chromium alloy and titanium alloy are currently the most widely used human bone tissue replacement materials. These metal materials are high in strength and easy to use. The preservation and processing technology is mature, and it is easy to process into various shapes to adapt to the outline of the bone. Studies have shown that the modulus of elasticity of biomaterials is critical for bone implants. Due to the large difference in elastic modulus between these metal implant materials and human bones, that is, the elastic modulus (110-220GPa) does not match the modulus of human bone (10-40GP...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/18A61L27/50A61L27/58A61L27/56
CPCA61L27/047A61L27/18A61L27/50A61L27/56A61L27/58A61L2430/02C08L67/04
Inventor 周应龙罗冬梅
Owner FOSHAN UNIVERSITY
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