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Preparation method of surface coating capable of lowering degradation rate of fully-degradable magnesium alloy vascular stent

A magnesium alloy blood vessel and degradation rate technology is applied in the field of surface coating preparation for reducing the degradation rate of a fully degradable magnesium alloy blood vessel stent, and can solve the problem of excessively fast degradation of the coating, loss of protective effect, and adhesion between the coating and the magnesium alloy substrate Weakness and other problems, to reduce the corrosion rate, inhibit the degradation of the substrate, easy to operate

Active Publication Date: 2014-12-10
JIANGSU FENGYUAN MEDICAL DEVICES CO LTD
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AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN201310306991.1 discloses a method for preparing a surface coating that can regulate the degradation rate of a magnesium alloy stent. The substrate of the stent is a Mg-Nd-Zn-Zr magnesium alloy, and the surface is coated with additive particles such as alkaline earth metals Polylactic acid and other polymers control the degradation rate of the coating by adjusting the content of additives, thereby controlling the degradation rate of the vascular stent, but the bonding force between the coating and the substrate is not good
[0008] It can be seen that in order to solve the defects that magnesium alloy is degraded too fast as a material for vascular stents, and there is not enough time to complete the functions of dredging blood vessels and promoting endothelial healing, the commonly used method is to coat polymer coatings, and the polymer is polylactic acid. , polycaprolactone and other polyester polymers, but the method of direct coating makes the bonding force between the coating and the magnesium alloy substrate weak, resulting in poor coating protection ability, premature and too fast degradation of the coating, peeling off and losing its protection effect

Method used

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  • Preparation method of surface coating capable of lowering degradation rate of fully-degradable magnesium alloy vascular stent
  • Preparation method of surface coating capable of lowering degradation rate of fully-degradable magnesium alloy vascular stent
  • Preparation method of surface coating capable of lowering degradation rate of fully-degradable magnesium alloy vascular stent

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preparation example Construction

[0040] Preparation of silane coupling agent coating, mixing silane coupling agent and organic solvent to form silane coupling grafting agent, using dip coating method to graft silane coupling grafting agent to the surface of magnesium alloy for biodegradable vascular stents , forming a cross-linked silane coupling agent layer after heating and curing;

[0041] The preparation of the polymer coating, the granular polymer is dissolved in an organic solvent and mixed to form a polymer spin coating solvent, and the polymer spin coating solvent is coated with the above steps by using a spin coating method The surface of the sample coated with the silane coupling grafting agent was vacuum-dried, and the polymer coating was formed after the polymer spin-coating solvent evaporated.

[0042] As an optimization, the silane coupling agent is γ-aminopropyltriethoxysilane KH550, N-(β-aminoethyl)-γ-aminopropylmethyldimethoxysilane KH602, γ-aminoethyl Any one of aminopropyltrimethoxysi...

Embodiment 1

[0051] In the first embodiment of the surface coating preparation method for reducing the degradation rate of fully degradable magnesium alloy stents involved in the present invention, the magnesium alloy used for biodegradable stents is Mg-Zn-Y-Nd, and the silane coupling agent is γ-Aminopropyltriethoxysilane KH550, the granular polymer is dissolved in 100,000 (LA:PA=75:25) polylactic acid-glycolic acid particles, and the organic solvent is dichloromethane solution. The method includes the following steps:

[0052] Step 1, preparation of silane coupling agent coating: Dissolving silane coupling agent γ-aminopropyltriethoxysilane KH550 in organic solvent dichloromethane to form silane with a volume percentage of 5% (v / v) The dichloromethane solution of the coupling grafting agent KH550 was stirred for 0.5h, and the biodegradable Mg-Zn-Y-Nd magnesium alloy wire cutting was processed into thin slices with a diameter of ?=10mm and a wall thickness of d=0.8mm, and polished to 2000...

Embodiment 2

[0056] In the second embodiment of the surface coating preparation method for reducing the degradation rate of fully degradable magnesium alloy stents involved in the present invention, the method includes the following steps:

[0057] Step 1, preparation of silane coupling agent coating: Dissolving silane coupling agent γ-aminopropyltriethoxysilane KH550 in dichloromethane to form a silane coupling with a volume percentage of 5% (v / v) The dichloromethane solution of grafting agent KH550 was stirred for 0.5h; the biodegradable magnesium alloy was wire-cut into thin slices with a diameter of ?=10mm and a wall thickness of d=0.8mm, and polished to 2000 # , after cleaning with acetone and deionized water, ultrasonic cleaning in absolute ethanol for 30min; soak the sample in 5% (v / v) silane coupling grafting agent KH550 solution for 1.0h, and silane coupling grafting agent KH550 branch to the surface of the magnesium alloy, heat and cure at 100°C for 60 minutes to form a cross-lin...

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Abstract

The invention relates to a preparation method of a surface coating capable of lowering the degradation rate of a fully-degradable magnesium alloy vascular stent. The method comprises the following steps: preparing a silane coupling agent on a magnesium alloy surface in a way that a silane coupling agent and an organic solvent are mixed, the silane coupling agent is grafted to the magnesium alloy surface of a biodegradable vascular stent by adopting a dip coating method and heating and curing are performed to form a coating; and preparing a polymer coating on the surface pre-treated by the silane coupling agent in a way that a spin-coating method is adopted to coat a polymer on a sample surface treated by the silane coupling agent, vacuum drying is realized and the polymer coating is formed after solvent volatilization. Through the technical scheme, a strong binding force exists between the polymer coating on the magnesium alloy surface pre-treated by the silane coupling agent and the surface of the fully-degradable magnesium alloy vascular stent, so that the magnesium alloy base body is prevented from excessively quick degradation, and the biocompatibility is improved; and as the coating is completely degraded with the base body at last, no toxic or side effects are brought to a human body.

Description

technical field [0001] The invention relates to the preparation of a magnesium alloy biological material, in particular to a method for preparing a surface coating for reducing the degradation rate of a fully degradable magnesium alloy vascular stent. Background technique [0002] Interventional vascular stent therapy has become the most important method in the field of cardiovascular disease treatment for more than ten years. The research on vascular stent materials has also experienced permanent bare stents, permanent drug-loaded stents, fully degradable metal stents and polymer stents. three stages of development. [0003] At present, most of the permanent bare stents used in clinical practice are stainless steel, cobalt-chromium alloy and nickel-titanium alloy. After completing the treatment function, they are still left in the human body as foreign bodies, which stimulate the vessel wall and significantly increase the intimal hyperplasia rate of the vessel. The resteno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08
CPCA61L31/10A61L31/022A61L2420/02A61L31/14C08L67/04
Inventor 奚廷斐刘婧王敏张志雄
Owner JIANGSU FENGYUAN MEDICAL DEVICES CO LTD
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