The invention relates to a substrate culture method for reducing continuous cropping obstacle of rehmannia, which comprises steps including 1sterilizing soil with 0.5% ethanol before planting; 2 adopting mixture of turf, vermiculite and pearlite as the substrate, spraying water containing fungicide before using, enabling water content of the substrate to reach 60%, maintaining for one week; 3 removing bottoms of nutrient earthen bowls or bottoms of nutrient bags, adding treated substrate into the nutrient earthen bowls or the nutrient bags, then placing and planting rehmannia into the nutrient earthen bowls or the nutrient bags, sowing the rehmannia on treated rectangular pieces of land in a field according to 25cm line spacing, 20cm row spacing, the holes are 8-10cm in depth, placing thenutrient earthen bowls or the nutrient bags planted with the rehmannia into the land, watering sufficiently, covering coil for about 0.5-1cm to facilitate moisturizing; and 4 performing field management according to normal planting during growth period. The substrate culture method for reducing continuous cropping obstacle of rehmannia effectively resolves the continuous planting obstacle problems that after one year of rehmannia planting, when the rehmannia is replanted, disease is serious, plants die in mass, yield is reduced sharply, and the rehmannia must be planted on other fields.