33results about How to "Negative without interference" patented technology

The invention relates to a quality control method for a rhizoma gastrodiae capsule and belongs to the technical field of biomedicine. The quality control method comprises the steps of raw material control, preparation method control, an identification method and a content measurement method. Modern drug production management is integrated in quality control. The quality of drugs and solvents used in production is examined from the source. Product quality control in the production process is established, perfect product quality standards are established, the thin-layer chromatographic detection ratio is higher than national requirements, the gastrodin content is greatly increased, the increase degree reaches 28.3%, and the quality and the therapeutic effect of the drug product are ensured.

The invention discloses a quality control method of a loins-strengthening and kidney-invigorating medicine. In the method, beautiful millettia root, rhizoma cibotii, kadsura coccinea, caulis spatholobi, parasitic loranthus and glossy privet fruit in the medicine are respectively identified by a thin layer chromatography; and the content of protocatechuic acid and the content of protocatechuic aldehyde in the medicine are measured via a liquid chromatography. In the quality control method established by the invention, the medicine material identifying method is mature and feasible, strong in specificity, negative and interference-free; the content measurement method is easy in operation, high in precision and good in reproducibility; and by adopting the quality control method disclosed by the invention, the quality of the medicine can be precisely and stably controlled to adapt to the industrial and stable production of the medicine.

The invention relates to a Lonicerae and Forsythiae detoxication soft capsule medicine and a preparation method and a quality detection method thereof, belonging to the field of traditional Chinese medicines. The Lonicerae and Forsythiae detoxication soft capsule comprises the following raw materials in parts by weight: 5 parts of Lonicerae, 5 parts of Forsythiae, 3 parts of mint, 2 parts of Schizonepeta, 2.5 parts of fermented soya beans, 3 parts of burdock (fried), 3 parts of Platycodon grandiflorum, 2 parts of lophatherum gracile and 2.5 parts of liquorice. The invention provides the preparation method of the medicine and also provides the quality detection method, wherein the quality detection method comprises five identification methods and a method for carrying out content determination by adopting a high performance liquid chromatography, and the methods can effectively control the quality of the Lonicerae and Forsythiae detoxication soft capsule.

The invention discloses a quality control method of an infant spleen tonifying medicament. According to the method, hawthorn and licorice in the medicament are identified by using layer chromatography respectively, and the hesperidin content of the medicament is measured by using liquid chromatography. In the established quality control method, the medicinal material identification method is mature, feasible, high in specificity, negative and non-interfering; the content measurement method is easy to operate, high in precision and high in reproducibility; and by adopting the quality control method, the quality of the medicament can be accurately and stably controlled to adapt to industrialized stable production of the medicament.

The invention relates to a detection method of a Jiuwei Zhuhuang preparation, comprising one or several kinds of the following identification and / or detection methods: identifying morphological characteristics of liquorice and safflower in the preparation by a microscope; qualitatively identifying the safflower, the liquorice and artificial cow-bezoar in the preparation by thin-layer chromatography; detecting the content of aconitine contained in bonga aconite in the preparation; and measuring the content of the hydroxyl carthamin yellow A contained in the safflower in the preparation by high performance liquid chromatography. The Jiuwei Zhuhuang preparation is effectively detected by the above detection method.

The invention provides a quality control method for an antirheumatic medicine. Besides the characters and inspection, the method also comprises the steps of identification, extract determination and assaying, wherein the identification step is to dissolve the content of the antirheumatic medicine--a rheumatalgia-relieving preparation in alcohol, carry out ultrasonic extraction to prepare a solution to be tested, prepare a comparison solution with the comparison crude drug of lilac daphne strips, and then carry out thin layer chromatographic comparison. The extract determination step is to carry out the alcohol backflow and leaching of the content of the antirheumatic medicine--the rheumatalgia-relieving preparation and determine the dry substance amount of the methanol extract. The assaying step is to carry out methanol backflow and leaching of the content of the antirheumatic medicine--the rheumatalgia-relieving preparation to prepare the solution to be tested, carry out the high pressure liquid chromatography detection together with the reference substance of daphnetin, and determine the content of the daphnetin in the content of the antirheumatic medicine--the rheumatalgia-relieving preparation. The method is suitable for the quality control of the antirheumatic medicine -the Rheumatalgia-relieving preparation including tablets, capsules, granules, pills, and the like.

The invention discloses an identification method of herba patriniae in a Chinese herbal compound, and particularly relates to a thin-layer identification method of herba patriniae in a Chinese herbal compound. The identification method comprises the following steps of preparing a reference crude drug solution; preparing a test product solution; preparing a negative sample solution; performing sample application on the same silica gel G thin-layer plate with a capillary sample applicator; placing the thin-layer plate into a chromatographic jar, performing expansion with an expanding agent, taking out and drying the thin-layer plate in air; and inspecting a thin-layer chromatographic sheet to obtain a result for identification, wherein a main spot of the same color is developed at a position, which corresponds to a reference crude drug chromatography, on a test product chromatography, but no spot is developed on a negative sample. The identification method disclosed by the invention is simple in technology, good in separation effect and extremely high in specificity; and the accuracy of component identification of herba patriniae in the Chinese herbal compound is further improved, and the identification method has a huge popularization and application potential in the field of identification of herba patriniae-related medicines.

The invention relates to a detection method of a yupingfeng oral liquid. A thin layer chromatography is adopted, the same sample pretreatment method and the same chromatographic condition are used, and astragali radix and saposhnidoviae radix in a yupingfeng oral liquid prescription are simultaneously identified on the same thin layer plate. The method of identifying the astragali radix and the saposhnidoviae radix by the thin layer chromatography comprises the steps of (1) test solution preparation, (2) reference solution preparation, and (3) thin layer chromatography conditions and result. According to the detection method, the quality standard of the yupingfeng oral liquid is improved and perfected, and the identification of the saposhnidoviae radix is revised from a high performance liquid chromatography to a thin layer identification method, so that the identification time is greatly shortened, and the detection cost is lowered. Compared with a method in the prior art, the detection method is simpler, more convenient, rapider and more economical; the quality is easier to control; and the detection method is more suitable for industrial production.

The invention relates to a method for determining the content of Qianlieping capsules. Liquid chromatography is used to measure the content of luteolin in Qianlieping preparations. On the basis of the original standard, the high-performance liquid chromatography of luteolin in Junyao Beibaijiang is added. As for content determination, methodological investigation proves that the method has good precision and accuracy, and is negative without interference. The whole test process is highly operable and can be used as one of the indicators for controlling the internal quality of this product. The invention has strong specificity for the content detection of Beibaijiang, is simple, fast and reliable, can more effectively control the quality of Qianlieping capsules, makes the quality of Qianlieping capsules stable and controllable, and ensures curative effect, thereby better meeting the needs of medical treatment .

The invention provides a detection method of a Qianlieping capsule for treating acute and chronic prostatitis. The detection method comprises a step that safflower in the above medicine is detected by adopting thin layer chromatography, wherein thin layer chromatography conditions are characterized in that a silica gel GF254 thin layer plate is adopted, and an A-B-C mixed solution having an A / B / C volume ratio of 5-12:1-5:0.1-0.7, preferably 7-11:1-3:0.1-0.5, and more preferably 9:2:0.5 is adopted as a developing solvent; the above A solution is selected from benzene, toluene, cyclohexane, trichloromethane, dichloromethane and n-butanol , and preferably cyclohexane; the above B solution is selected from acetone, ethyl acetate, butyl acetate, methanol and glycol, and preferably ethyl acetate; and the above C solution is selected from water, methyl formate, dimethyl ether, acetate acid gracial and formic acid, and preferably acetate acid gracial. The method allows the quality of the medicine to be effectively controlled, and to be stable, controllable, efficient and safe.

Disclosed is a quality control method for infantile accumulation-eliminating granules. The method comprises: using thin-layer chromatography to perform qualitative identification on parched Crataegi fructus and Pharbitidis semen in infantile accumulation-eliminating granules; using high-performance liquid chromatography to determine the content of an activation component, arecoline, in the infantile accumulation-eliminating granules to carry out quantitative control; and using a potentiometric titration method to determine the content of organic acids in the infantile accumulation-eliminating granules. The method of the present invention is simple, has a good degree of separation, strong specificity and good reproducibility, thereby effectively guaranteeing the quality and curative effect of the infantile accumulation-eliminating granules, and having very strong practicality.

The invention provides a detection method of a medicine for treating epileptoid convulsion, infantile convulsion and mimic convulsion. The detection method comprises a step that Salvia miltiorrhiza in the medicine by adopting thin layer chromatography, wherein thin layer chromatography conditions are characterized in that a silica gel G thin layer plate is adopted, and an A-B-C mixed solution having an A / B / C volume ratio of 70-100:5-10:1-5, preferably 80-100:6-9:1-4, and more preferably 90:8:2 is adopted as a developing solvent; the above A solution is selected from dichloromethane, benzene, toluene, trichloromethane, isopropanol and n-butanol, and preferably trichloromethane; the above B solution is selected from ethanol, ethyl acetate, acetone, glycol, methanol and dioxin, and preferably methanol; and the above C solution is selected from formic acid, acetate acid gracial, dimethyl ether, methyl formate and water, and preferably formic acid. The method allows the quality of the medicine to be effectively controlled, and to be stable, controllable, efficient and safe.