The embodiment of the invention provides a Bluetooth communication method and device, and is applied to a Bluetooth communication system, the Bluetooth communication system comprises a TWS Bluetooth earphone and a terminal equipment, the TWS Bluetooth earphone comprises a first earphone and a second earphone, the terminal equipment controls the TWS Bluetooth earphone to be in a first mode, the first earphone is used for collecting sound signals in the first mode, the second earphone is used for playing a sound signal, the first earphone is held on a hand of a user, the second earphone is worn on an ear of the user, and when an audio app on the terminal equipment is started, the first earphone collects a first sound signal, carries out sound effect processing on the first sound signal to obtain a second sound signal, and sends the second sound signal to the second earphone; and the terminal equipment sends the accompaniment audio to the second earphone, and the second earphone carries out sound mixing processing on the accompaniment audio and the second sound signal and then plays the audio. The first earphone held on the hand of the user can be closer to the mouth of the user, so that the high requirement of the user on sound detail pickup can be met. One earphone is held by hand, the other earphone is worn on the ear, the held earphone is specially used for pickup, the earphone worn on the ear is specially used for listening back, the behavior habit that a user holds a microphone by hand under the normal karaoke condition is met, and the function of real-time listening back can be achieved.