The invention discloses wintercherry effervescent tablets with a blood glucose reduction function and a preparation method of the wintercherry effervescent tablets, belongs to the field of functional drinks for diabetic patients to drink and solves the technical problems that the wintercherry juice tastes sour and bitter and drinking people are limited. The wintercherry effervescent tablets are prepared from raw materials as follows: 42% of freeze-dried fruit powder, 21% of citric acid, 32% of sodium bicarbonate, 4% of PEG (polyethylene glycol) 6000 and 1% of aspartame. According to the method, the freeze-dried fruit powder is prepared from wintercherry juice, Physalis pubescens juice and maltodextrin; two parts of freeze-dried fruit powder are taken, aspartame is added to one part of the freeze-dried fruit powder and uniformly mixed, citric acid is added, the mixture is uniformly mixed, a 10% PVP (polyvinylpyrrolidone) ethanol solution is sprayed, and acidic particles are prepared; aspartame is added to the other part of the freeze-dried fruit powder and uniformly mixed, sodium bicarbonate is added, the mixture is uniformly mixed, a 10% PVP ethanol solution is sprayed, and alkaline particles are prepared; the acidic particles and the alkaline particles are dried and mixed uniformly, PEG 6000 is uniformly mixed, and the wintercherry effervescent tablets are prepared after tableting and sterilization. The solid functional drink which can clear heat and soothe the throat, is particularly suitable for the diabetic patients to drink and is very convenient to store, carry and take is researched for vast consumers.