The invention relates to a fingertip three-dimensional contact force sensing device and method capable of keeping touch sense, the device is of a symmetrical structure and comprises a base, an adaptive pad is installed on the upper portion of an inner cavity of the base, side plates are connected to the two sides of the base, and radial film sensors are installed on the inner sides of the side plates; sensor grooves are symmetrically formed in the lower portion of the base, axial film sensors are installed in the sensor grooves, and the axial film sensors are correspondingly matched with contact heads symmetrically installed on the front portion of an inner cavity of the base. The method comprises the following steps: applying pressure to the three-axis pressure sensing device along different directions after the device is worn, and collecting four paths of film sensor signals and three paths of three-axis pressure sensor signals; then, sending into a multiple regression learning system, and establishing a fingertip contact force estimation model through an index GPR (General Purpose Regression); finally, the human finger wearing device applies pressure to the object, signals of the four thin film sensors are sent into a fingertip contact force estimation model, and estimated three-dimensional contact force is obtained. The invention has the characteristics of light weight, human body fitting, short calibration time and the like.