The invention discloses a computer board card cleaning device comprising a barrel body. The lower end of the barrel body is provided with an air guiding cover, the upper end of the barrel body is equipped with a tail cover, the lower end of the air guiding cover is provided with a mesh hole plate, the lower end of the mesh hole plate is fixedly connected with a hairbrush, the left end of the air guiding cover is provided with a clamping slot, the right end of the air guiding cover is provided with a first through hole, a filtering net is slidely connected to the interior of the first through hole in a sleeved manner, a left magnetic ring is mounted on the right end of the air guiding cover, and a second through hole is formed in the inner side of the left magnetic ring. According to the computer board card cleaning device, through cooperation of the mesh hole plate, the hairbrush, a micro motor, fan blades and the filtering net, a large amount of dust which is sucked and filtered can be removed, and respiratory tract harms caused by the fact that an operator inhales the dust are avoided; and through cooperation of the tail cover, a support frame, a dust suction cloth bag and an outer thread nut, disassembly, assembly, cleaning and replacement of the dust suction cloth bag are facilitated, the design of the dust suction cloth bag can perform secondary filtration on the dust, anddust pollution to the environment is effectively reduced.