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This invention provides a process for making microporous membranes from a polymer solution and the membranes therefrom. A thermal assist, such as heating of the polymer solution can be effected subsequent to shaping the solution, such as by forming a film, tube or hollow fiber of the solution under conditions that do not cause phase separation.. In a preferred embodiment, the formed solution is briefly heated to generate a temperature gradient through the body of the formed solution. The polymer in solution then is precipitated to form a microporous structure. The formation of a wide variety of symmetric and asymmetric structures can be obtained using this process. Higher temperatures and / or longer heating times effected during the heating step result in larger pore sizes and different pore gradients in the final membrane product.

An apparatus and system for accessing a flow system (such as a subsea tree) in a subsea oil and gas production system, and method of use. The apparatus comprises a body defining a conduit therethrough and a first connector for connecting the body to the flow system. A second connector is configured for connecting the body to an intervention apparatus, such as an injection or sampling equipment. In use, the conduit provides an intervention path from the intervention apparatus to the flow system. Aspects of the invention relate to combined injection and sampling units, and have particular application to well scale squeeze operations.

The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the use of long acting GLP-1 receptor agonists to improve insulin sensitivity or lipid profiles in obesity and related therapeutic and / or diagnostic compositions, methods and devices.

The invention provides a flow control valve for a subsea hydrocarbon production system and a method of use. The flow control valve comprises an inlet configured to be in fluid communication to an injection fluid conduit and an outlet configured to be in fluid communication with a subsea flow system. A flow control mechanism is disposed in a flow path between the inlet and the outlet and is arranged to adjust a flow rate through the flow path. The flow control mechanism is configured to automatically adjust the flow rate of injection fluid through the flow path according to a pressure differential between fluid pressure at the inlet and fluid pressure at the outlet. Adjustment may be self-regulating, or may be controlled by a hydraulic control circuit.

The invention in one of its aspects provides a connection apparatus for a subsea hydraulic circuit and method of use in a sampling application. The apparatus comprises a longitudinal body configured to be removably docked with a subsea hydraulic circuit receptacle. The body comprises a plurality of radial ports axially displaced along the body, and an axial bore accommodating a spool having at least one fluid barrier. The spool and fluid barrier are actuable to be axially moved in the bore to control axial flow paths along the bore between the plurality of radial ports. The apparatus may be configured as a sampling hot stab in an application to sampling a production fluid from a subsea hydrocarbon production system.

The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

The invention provides a flow control valve for a subsea hydrocarbon production system and a method of use. The flow control valve comprises an inlet configured to be in fluid communication to an injection fluid conduit and an outlet configured to be in fluid communication with a subsea flow system. A flow control mechanism is disposed in a flow path between the inlet and the outlet and is arranged to adjust a flow rate through the flow path. The flow control mechanism is configured to automatically adjust the flow rate of injection fluid through the flow path according to a pressure differential between fluid pressure at the inlet and fluid pressure at the outlet. Adjustment may be self-regulating, or may be controlled by a hydraulic control circuit.

The invention provides an apparatus and system for accessing a flow system (such as a subsea tree) in a subsea oil and gas production installation, and method of use. The apparatus comprises a body and a plurality of connectors configured to connect the apparatus to the flow system. A flow access interface is provided on the body for connecting the apparatus to a subsea process apparatus, and the body defines a plurality of flow paths. Each flow path fluidly connects one of the plurality of connectors to the flow access interface to provide an intervention path from a connected subsea process apparatus to the flow system in use. Aspects of the invention have particular application to flow metering, fluid sampling, and well scale squeeze operations.

Semiconductor wafers with a diameter of at least 200 mm comprise a silicon carrier wafer, an electrically insulating layer and a semiconductor layer located thereon, the semiconductor wafer having been produced by means of a layer transfer process comprising at least one RTA step, wherein the semiconductor wafer has a warp of less than 30 μm, a DeltaWarp of less than 30 μm, a bow of less than 10 μm and a DeltaBow of less than 10 μm. Processes for the production of a semiconductor wafer of this type require specific heat treatment regimens.

The invention relates to a multi-purpose tile system, in particular a floor tile system, comprising a plurality of multi-purpose tiles, in particular floor tiles, wall tiles, or ceiling tiles. The invention also relates to a tile covering, in particular floor covering, ceiling covering, or wall covering, consisting of mutually coupled tiles according to the invention. The invention further relates to a tile for use in multi-purpose tile system according to the invention.

A metallic pipe connection may comprise a tubular body and a terminal tubular engagement portion configured to be engaged on a pipe and to be fixed thereto by means of plastic deformation of the engagement portion, and a terminal flange on the opposite side of the tubular body with respect to that one provided with the tubular engagement portion. The tubular engagement portion may include an annular seat for a sealing gasket, having a first housing groove for the sealing gasket which may be internally open towards the tubular engagement portion, and at least part of the tubular engagement portion and the annular seat may be plastically deformed such to generate a mechanical seal on the pipe on which the tubular engagement portion is fitted.

A valve apparatus (400) for a flow system in a subsea oil and gas production installation and a method of use. The valve apparatus comprises an inlet for production flow from the subsea oil and gas production installation, an outlet for production flow, and a flow control valve (420) disposed between the inlet and the outlet. A first flow line (361) in communication with a sampling circuit is disposed between the inlet and the flow control valve, and a second flow line (362) in communication with a sampling circuit is disposed between the outlet and the flow control valve. The flow control valve is operable to be partially closed to create a pressure differential between the first and second flow lines, and thereby drive a production fluid into the sampling circuit.

The device comprises at least one module for stitching the tread and a means for moving the module vertically and horizontally. The stitching module comprises a frame which is provided with a fixed stitching assembly, equipped with spikes, and at least one mobile stitching assembly. The at least one mobile stitching assembly comprises at least one stitching plate provided at the base of same with at least one planar horizontal contact surface, from which at least two spikes protrude. The plate is arranged in a vertical guide space provided in the frame such that the spikes protrude downwards and such that it is free to move vertically in this space over a limited travel path. The device also includes a vertical movement device for moving the plate from the top downwards in this guide space and a device for locking the altitude position of the plate in this space.

A metal cutting drill insert for a drill tool having a chip disruptor provided at a rake face. The chip disruptor is further configured with a chamfer at a leading cutting edge region to increase cutting resistance and facilitate chip breakage.