38 results about "Mitochondrial mutation" patented technology

The present invention provides methods for diagnosing and treating Parkinson's disease based on mitochondrial mutations. The present invention also provides methods for diagnosing and treating other diseases and disorders based on mitochondrial mutations.

The invention relates to the field of gene technology, in particular to a primer-pair-probe combination product for detecting mitochondrial 3243A>G mutation, a kit and a detection method thereof. The invention uses ARMS combined with fluorescent PCR technology to have high specificity and high sensitivity, short detection time, low cost, intuitive and easy interpretation of results.

The present invention publicly predicts the method of mitochondrial DNA mutation threshold, fertility risk and egg retrieval, including the following steps: first establish a mitochondrial mutant probability predictive model and estimate the mutation threshold S, then establish a maternity risk prediction model, and predict the maternity risk of mutant carrier carrier.P, then use two distributions to establish an egg mother cell extraction predictive model and calculate the number of egg retrieval of the mutant carrier; the prediction model of the incidence of the present invention predicts the threshold of common MTDNA mutations, and predicts the mother's fertility risk and PGT egg retrieval numberOn the basis of the establishment of a maternity risk prediction model and an egg retrieval prediction model, you only need to know that the mitochondrial DNA mutation ratio of the mutant carrier can calculate the minimum PGT egg collection required by the healthy child generation.Help clinicians to conduct genetic management of families carrying MTDNA heterogeneous mutations and provide genetic consultation, and provide standard guidelines for PGT.